Results 71 to 80 of about 107,429 (283)

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source

Real-practice thromboprophylaxis in atrial fibrillation [PDF]

, 2017
This retrospective observational study was based on databases of the Local Health Authority of Treviso, Italy. It evaluated the prevalence and the effectiveness of oral anticoagulation treatment (OAT) for the management of nonvalvular atrial fibrillation
Bettiol, Alessandra, Bolcato, Jenny, Chinellato, Alessandro, Deambrosis, Paola, Franchin, Giulia, Giusti, Pietro, Pellizzari, Michele, Pirolo, Roberta, Themistoclakis, Sakis   +8 more
core   +2 more sources

Pioglitazone after Ischemic Stroke or Transient Ischemic Attack [PDF]

New England Journal of Medicine, 2016
Patients with ischemic stroke or transient ischemic attack (TIA) are at increased risk for future cardiovascular events despite current preventive therapies. The identification of insulin resistance as a risk factor for stroke and myocardial infarction raised the possibility that pioglitazone, which improves insulin sensitivity, might benefit patients ...
Kernan, W. N, Viscoli, C. M., Furie, K. L., Young, L. H., Inzucchi, S. E., Gorman, M., Guarino, P. D., Lovejoy, A. M., Peduzzi, P. N., Conwit, R., Brass, L. M., Schwartz, G. G., Adams, H. P., Berger, L., CAROLEI, ANTONIO, Clark, W., Coull, B., Ford, G. A., Kleindorfer, D., O'Leary, J. R., Parsons, M. W., Ringleb, P., Sen, S., Spence, J. D., Tanne, D., Wang, D., Winder, T. R., IRIS Trial Investigators, SACCO, SIMONA   +28 more
openaire   +5 more sources

Identifying Myeloid‐Derived Suppressor Cells and Lipocalin‐2 as Therapeutic Targets for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Inflammatory dysregulation drives intervertebral disc degeneration via stage‐dependent immune cellular dynamics. Single‐cell transcriptomics and genetic risk mapping revealed a shift from LCN2high myeloid‐derived suppressor cells maintaining disc repair in early stages to IL1B+ macrophage‐dominated pathology in advanced disease.
Changmeng Zhang, Haoyun Li, Hongfei Wang, Liangyu Shi, Ying Shing Chan, Yu Wang, Graham Ka Hon Shea   +6 more
wiley   +1 more source

Prescription smoking-cessation medication pharmacy claims after stroke and transient ischemic attack

Preventive Medicine Reports, 2022
Smoking cessation is critical in secondary prevention after stroke and transient ischemic attack. Data regarding use of smoking-cessation interventions after stroke and transient ischemic attack are sparse.
Neal S. Parikh, Yongkang Zhang, Daniel Restifo, Erika Abramson, Matthew J. Carpenter, Babak B. Navi, Hooman Kamel   +6 more
doaj  

Transient ischemic attack is a multidisciplinary problem

Неврология, нейропсихиатрия, психосоматика, 2012
The paper discusses the issues associated with the definition of the concept «transient ischemic attack» (TIA) and with the prognosis of cerebrovascular disease after prior TIA.
Valentina Vladimirovna Gudkova, T V Shanina, E A Petrova, L V Stakhovskaya   +3 more
doaj   +1 more source

Letter by Scheitz et al regarding article, "Randomized controlled trial of early versus delayed statin therapy in patients with acute ischemic stroke: ASSORT trial (administration of statin on acute ischemic stroke patient)" [PDF]

, 2018
No abstract ...
Endres, Matthias, Lees, Kennedy R., Scheitz, Jan F.   +2 more
core   +1 more source

Reinforcing Stromal Cell Spheroid Through Red‐Light Preconditioning for Advanced Vascularization

Advanced Science, EarlyView.
This study presents a novel approach to enhance stromal cell therapy for myocardial infarction by combining OLED‐based photobiomodulation (OPBM) preconditioning with 3D spheroid culture of hADSCs. The engineered spheroids improve angiogenesis, arterialization, and cardiac function in vivo, offering a next‐generation therapeutic strategy to overcome ...
Yu‐Jin Kim, Hyeok Kim, Dong‐Hyun Lee, Yeong Hwan Kim, Jae‐Hyun Park, Woo‐Sup Sim, Jin‐Ju Kim, Kiwon Ban, Soong Ho Um, Hyun Ji Park, Michael E. Davis, Hun‐Jun Park, Suk Ho Bhang   +12 more
wiley   +1 more source

Elevated serum neopterin and homocysteine increased the risk of ischemic stroke in patients with transient ischemic attack

Pteridines, 2019
Objective: To investigate the correlation between serum neopterin, homocysteine (Hcy) and the risk of developing ischemic stroke (IS) in patients with transient ischemic attack (TIA).
Xie Jing, Qiu Xiandi, Ji Chunli, Liu Chunhong, Wu Yueming   +4 more
doaj   +1 more source