Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation
Advanced Science, EarlyView.LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao +9 more
wiley +1 more source
Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging [PDF]
, 2021 Ivo Planinc +11 more
openalex +1 more source
Adamts1 Exacerbates Post‐Myocardial Infarction Scar Formation via Mechanosensing of Integrin α8
Advanced Science, EarlyView.Proposed mechanistic model of ADAMTS1‐ITGα8 mechanotransduction in post‐MI scar formation. Schematic illustration showing the mechanistic pathway by which endothelial cell (EC) derived Adamts1 regulates cardiac fibroblast activation through ITGα8‐mediated mechanotransduction following myocardial infarction (MI).
Chun‐Yan Kong +11 more
wiley +1 more source
Advanced Science, EarlyView.Norepinephrine/α2B‐adrenoceptor axis promotes the secretion of Notch2 intracellular domain (N2ICD)‐enriched extracellular vesicles (EVs) from macrophages. These EVs deliver N2ICD into fibroblasts, thereby inducing their activation. Deletion of Notch2 or α2B‐AR in macrophages disrupts N2ICD‐enriched EV formation and alleviates kidney fibrosis in mice ...
Huiwen Ren +14 more
wiley +1 more source
In-room treadmill exercise stress cardiac magnetic resonance in patients with suspected ischemic heart disease [PDF]
, 2009 Subha V. Raman +4 more
openalex +1 more source
Advanced Science, EarlyView.In contrast to the adult mammalian heart, which lacks regenerative capacity, the neonatal heart retains a transient regenerative capacity. In this study, high mobility group box 2 (HMGB2) is identified as a crucial protein driving heart regeneration based on comprehensive analyses using quantitative proteomics with tandem mass tag (TMT) labelling, RNA ...
Liu‐Hua Zhou +17 more
wiley +1 more source
Noise and ischemic heart disease
Scandinavian Journal of Work, Environment & Health, 2012 The incidence and mortality of ischemic heart disease (IHD) declined dramatically in affluent countries from the early 1980s until at least the mid 1990s (1).
Jens Peter Bonde, Henrik A Kolstad
doaj +1 more source
FMO2 Promotes Angiogenesis via Regulation of N‐Acetylornithine
Advanced Science, EarlyView.This study identifies flavin‐containing monooxygenase 2 (FMO2) as a novel proangiogenic regulator in endothelial cells. Targeted FMO2 ablation impairs vessel sprouting, whereas its compensation potently enhances angiogenesis. Metabolomics and single‐cell sequencing reveal that FMO2 drives vascular growth via the N‐acetylornithine/ATF3/NOTCH1 axis ...
Jingyi Wang +15 more
wiley +1 more source
Investigating the effects of statins on ischemic heart disease allowing for effects on body mass index: a Mendelian randomization study [PDF]
, 2022 Shun Li, C. Mary Schooling
openalex +1 more source
Risk of ischemic heart disease in women after radiotherapy for breast cancer.
New England Journal of Medicine, 2013 S. Darby +15 more
semanticscholar +1 more source