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Bone Marrow Stem Cell Treatment for Ischemic Heart Disease in Patients with No Option of Revascularization: A Systematic Review and Meta-Analysis
, 2013 PMCID: PMC3686792This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...Brunskill, SJ, Anthony Mathur, Fisher Sheila A., Doree, C, Dorée Carolyn, Martin-Rendon, E, Brunskill Susan J., Enca Martin-Rendon, Enca Martin-Rendon (162178), Fisher, SA, Mathur Anthony, Martin-Rendon Enca, Susan J Brunskill, Susan J. Brunskill (162133), Sheila A. Fisher (162124), Carolyn Dorée (5655262), Anthony Mathur (162155), Sheila A Fisher, Carolyn Dorée, Mathur, A +19 morecore +1 more sourceCD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation
Advanced Science, EarlyView.ABSTRACT
Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui +10 morewiley +1 more sourceIschemic heart disease in diabetic and non-diabetic patients
Revista Habanera de Ciencias Médicas, 2017 Introduction:Ischemic heart disease has Diabetes mellitus as one of its most important factors, because affects the prognosis, treatment, severity, morbidity and mortality of the first one. Objective: To characterize the influence of diabetes mellitus on Aozi Feng, Yamilé Peña, Wan Lidoaj Common variants at 6p21.1 are associated with large artery atherosclerotic stroke [PDF]
, 2012 Genome-wide association studies (GWAS) have not consistently detected replicable genetic risk factors for ischemic stroke, potentially due to etiological heterogeneity of this trait.Rodney J Scott, Barlera, S., Brott, TG, Verhaaren, BF, Ross Baker, Furie, Karen L., Psaty, Bruce M., Mitchell, Braxton D., Brott, Thomas G., Boerwinkle, E., Scott, Rodney J., Markus, Hugh S, Fornage, Myriam, Lincz, Lisa F, Matthew Traylor, Oldmeadow, C., Attia, J., McEvoy, M., Rothwell, Peter M., Andreas Gschwendtner, Rosand, Jonathan, Cole, J.W., Worrall, Bradford B, Holliday, Elizabeth G, Levi, C., Bis, Joshua C, Robert D Brown, Mark McEvoy, Koblar, S.A., Parsons, Mark W., Koblar, Simon A, Pankaj Sharma, Benjamin F J Verhaaren, Sharma, P, Parati, E.A., Worrall, BB, Moscato, Pablo, Evans, TJ, Steve Bevan, Farrall, M, Rothwell, Peter M, Brown, RD, Brown, Robert D, William J Devan, Bradford B Worrall, Boerwinkle, Eric, Lisa F Lincz, Levi, Christopher, Nalls, Michael A., Stefansson, K, Maguire, Jane M, Sudlow, Catherine; id_orcid, Wiggins, Kerri L., Martin Farrall, Longstreth, W T, Moscato, P, Psaty, Bruce M, John W Cole, Boerwinkle, E, Brown, Robert D., Biros, Erik, Furie, K.L., Maguire, J.M., Bis, JC, Simona Barlera, Kari Stefansson, Sturm, Jonathan W, Peel, R, Rothwell, P.M., Jannes, J, Mark W Parsons, Thomas H Mosley, M Arfan Ikram, Christopher Levi, Jannes, Jim, McEvoy, Mark, Devan, William J, Dichgans, M., Lewis, Martin D, Unnur Thorsteinsdottir, Boncoraglio, Giorgio B, Baker, R, Peter M Rothwell, Golledge, J, Hankey, GJ, Jonathan Rosand, W T Longstreth, Holliday, EG, Rosand, J., James F Meschia, Cheng, YC, Wiggins, K.L., Maguire, JM, Verhaaren, B.F.J., Meschia, JF, Graeme J Hankey, Gudmar Thorleifsson, Scott, R.J., Levi, C, Scott, Rodney J, Rainer Malik, Koblar, SA, Verhaaren, Ben, Bis, J.C., Hankey, Graeme J., Smith, W., Barlera, S, Lewis, M.D., Devan, William J., Bevan, S, Jane M Maguire, Wiggins, KL, Boncoraglio, Giorgio B., Verhaaren, BFJ, Sudlow, C, Furie, Karen L, Grétarsdóttir, S, Lincz, LF, Worrall, Bradford B., Mitchell, Braxton D, Mosley, Thomas H, Thomas G Brott, Jannes, J., Malik, R., Boncoraglio, GB, Nalls, M.A., Koblar, S., Thorsteinsdottir, Unnur, Fornage, M., Wayne Smith, Traylor, M, Boncoraglio, G.B., Biros, E., Mosley, TH, Attia, John, Grétarsdóttir, S., Oldmeadow, Christopher, Parati, Eugenio A, Stefansson, K., Wiggins, Kerri L, Markus, HS, Kerri L Wiggins, Devan, WJ, Hugh S Markus, Bis, Joshua C., Ikram, M Arfan, Ikram, M.A., Rosand, J, Dichgans, M, Verhaaren, Benjamin F J, McEvoy, M, Farrall, M., Thorleifsson, G, Malik, R, Longstreth, W.T., Grétarsdóttir, Sólveig, Mitchell, BD, Golledge, Jonathan, Giorgio B Boncoraglio, Baker, Ross, Tiffany-Jane Evans, Holliday, Elizabeth G., Sturm, Jonathan W., Erik Biros, Farrall, Martin, Sharma, Pankaj, Brott, T.G., Stefansson, Kari, Karen L Furie, Rothwell, PM, Golledge, J., Lewis, Martin D., Ikram, M. Arfan, Sharma, P., Peel, Roseanne, Martin Dichgans, Cheng, Yu-Ching, Smith, Wayne, Jonathan W Sturm, Parati, EA, Attia, J, Cotlarciuc, Ioanna, Barlera, Simona, Cathie Sudlow, Nalls, MA, Cheng, Y-C, Fornage, M, Baker, R., Oldmeadow, C, Cotlarciuc, Ioana, Gschwendtner, A., Bevan, Steve, Thorsteinsdottir, U., Yu-Ching Cheng, Lewis, M., Maguire, Jane M., Ikram, MA, Smith, W, Longstreth, WT, Holliday, E.G., Scott, RJ, Worrall, B.B., Meschia, James F, Gschwendtner, Andreas, Dichgans, Martin, Lewis, MD, Jim Jannes, Thorleifsson, G., Michael A Nalls, Devan, W.J., Gschwendtner, A, Brown, Robert D., Jr., Roseanne Peel, Bruce M Psaty, Cotlarciuc, I, Eugenio A Parati, Brown, R.D., Holliday, E., Hankey, G.J., Simon A Koblar, Elizabeth G Holliday, Thorleifsson, Gudmar, Thorsteinsdottir, U, Evans, T-J, Sudlow, C., Christopher Oldmeadow, Verhaaren, Benjamin F.J., John Attia, Lincz, L.F., Mosley, Thomas H., Markus, H.S., Psaty, BM, Pablo Moscato, Sólveig Grétarsdóttir, Nalls, Michael A, Sturm, JW, Parsons, MW, Peel, R., Mosley, T.H., Jonathan Golledge, Martin D Lewis, Sturm, J.W., Parati, Eugenio A., Cole, John W, Ikram, Arfan, Traylor, M., Psaty, B.M., Hankey, Graeme J, Biros, E, Meschia, J.F., Joshua C Bis, Ioana Cotlarciuc, Mitchell, B.D., Markus, Hugh S., Myriam Fornage, Eric Boerwinkle, Brott, Thomas G, Bevan, S., Moscato, P., Parsons, Mark W, Sudlow, Cathie, Cole, John W., Furie, KL, Parsons, M.W., Koblar, Simon A., Lincz, Lisa F., Meschia, James F., Malik, Rainer, Braxton D Mitchell, Cotlarciuc, I., Evans, Tiffany-Jane, Cole, JW, Traylor, Matthew +272 morecore +1 more sourceG3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Advanced Science, EarlyView.Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou +9 morewiley +1 more sourceEndoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability
Advanced Science, EarlyView.The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov +13 morewiley +1 more sourceISCHEMIC HEART DISEASE
, 2021 Treatment of ischemic heart disease is carried out therapeutically and surgically.Diet is important in ischemic heart disease. It is necessary to limit the total amount and calories of food, try to maintain a healthy weight, exercise, combine work and ...Azizova Salomat Erkinjon kizi, Azizov Salohiddin Erkinjonovich +1 morecore Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy
Advanced Science, EarlyView.Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim +11 morewiley +1 more source
