Results 41 to 50 of about 924,610 (305)

GENETICS OF ISCHEMIC STROKE

Clinical and Experimental Hypertension, 2002
Genetic factors are important in the pathogenesis of cerebrovascular diseases. Stroke represents a multifactorial polygenic disorder where the role of environmental factors is quite well defined as opposed to the role of genetic factors which needs to be further elucidated.
Venti M., PARNETTI, Lucilla, GALLAI, Virgilio   +2 more
openaire   +3 more sources

HDAC4 in ischemic stroke: mechanisms and therapeutic potential

Clinical Epigenetics, 2018
Stroke is one of the leading causes of death and disability worldwide, and the majority of the cases are ischemic stroke. However, it still lacks effective treatment except for thrombolytic therapy in an extremely narrow time window.
Qingsheng Kong, Yongnan Hao, Xin Li, Xin Wang, Bingyuan Ji, Yili Wu   +5 more
doaj   +1 more source

SUMOtherapeutics for Ischemic Stroke

Pharmaceuticals, 2023
Small, Ubiquitin-like Modifier (SUMO) is a post-translational modifier with a profound influence on several key biological processes including the mammalian stress response. Of particular interest is its neuroprotective effects, first recognized in the 13-lined ground squirrel (Ictidomys tridecemlineatus), in the context of hibernation torpor. Although
Paramesh Karandikar, Jakob V. E. Gerstl, Ari D. Kappel, Sae-Yeon Won, Daniel Dubinski, Monica Emili Garcia-Segura, Florian A. Gessler, Alfred Pokmeng See, Luca Peruzzotti-Jametti, Joshua D. Bernstock   +9 more
openaire   +5 more sources

Associations of proinflammatory cytokines with the risk of recurrent stroke [PDF]

, 2008
<p><b>Background and Purpose:</b> There are few reports on proinflammatory cytokines and risk of primary or recurrent stroke. We studied the association of interleukin (IL)-6, IL-18, and tumor necrosis factor-α (TNF-α) with recurrent ...
Welsh, P., Chalmers, J., Lowe, G.D., Welsh, P, Woodward, M, Lowe, GD, MacMahon, SW, Neal, B.C., Campbell, DJ, Neal, BC, MacMahon, S.W., Rumley, A., Campbell, D., Chalmers, J, MacMahon, Stephen, Rumley, A, Woodward, M.   +16 more
core   +1 more source

A study on structural imaging changes and serum neurofilament light chain (NfL) levels in individuals with white matter hyperintensities, combining imaging techniques with biomarker analysis

IBRO Neuroscience Reports
Objective: To elucidate the association between serum neurofilament light chain (NfL) levels and structural brain alterations in individuals exhibiting white matter hyperintensities (WMHs), as well as to investigate the potential utility of serum NfL as ...
Meini Wu, Zihao Li, Yuhang Ren, Siou Li, Weina Zhao, Jian Xing, Jiangnan Yi, Fengze Zhao, Changhao Yin   +8 more
doaj   +1 more source

Microbiome and ischemic stroke: A systematic review.

PLoS ONE, 2021
BackgroundIschemic stroke is one of the non-communicable diseases that contribute to the significant number of deaths worldwide. However, the relationship between microbiome and ischemic stroke remained unknown.
Yee Teng Lee, Nor Ismaliza Mohd Ismail, Loo Keat Wei   +2 more
doaj   +1 more source

Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats [PDF]

, 2009
<p><b>Background and Purpose:</b> Stroke-prone spontaneously hypertensive rats (SHRSP) are a highly pertinent stroke model with increased sensitivity to focal ischemia compared with the normotensive reference strain (Wistar-Kyoto rats ...
Dominiczak, Anna F., Graham, Delyth, Macrae, I. Mhairi, Gallagher, Lindsay, Gsell, Willy, McCabe, Christopher   +5 more
core   +1 more source

Ischemic Stroke During the Pandemic in a Secondary Care Hospital: COVID-19 and Its Collateral Effects

Batı Karadeniz Tıp Dergisi, 2023
Aim: Ischemic stroke is among the leading causes of death and disability. Although recent studies haveshown a possible relationship between COVID-19 and ischemic stroke, the effect of the pandemic period,which may be another factor in the increase of ...
Elif Uygur Kucukseymen, Ebru Balaban, Şenay Öztürk Durmaz   +2 more
doaj   +1 more source

The Virtual International Stroke Trials Archive [PDF]

, 2007
Background and Purpose - Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal.
Donnan, Geoffrey A., Kaste, M., HENNERICI, Michael G, Teal, P., Gregson, B.A., Hacke, Werner, Marler, J.R., Marler, John R., Fisher, M., GREGSON, Barbara A, Wahlgren, Nils-Gunnar, Curram, John, Grotta, J., MARLER, John R, Davis, Stephen M., Sacco, Ralph L., Donnan, G.A., Myzoon, Ali, Bath, Philip M.W., Teal, Philip, WEIR, Christopher J, Weir, C.J., Gregson, Barbara A., Fisher, Marc, Hommel, Marc, Hacke, W., BATH, Philip M. W, Sacco, R.L., Diener, Hans-Christoph, Warach, S., DONNAN, Geoffrey A, Hennerici, Michael G., Wahlgren, N.-G., Lees, K.R., Grotta, James, Hennerici, M.G., Kaste, Markku, Weir, Christopher J., Warach, Steven, Lees, Kennedy R., DAVIS, Stephen M, Bath, P.M.W., Ali, M., Curram, J., Diener, H.-C., Ali, Myzoon, Davis, S.M., SACCO, Ralph L, Hommel, M., LEES, Kennedy R   +49 more
core   +1 more source

Factors associated with intracerebral hemorrhage after thrombolytic therapy for ischemic stroke pooled analysis of placebo data from the Stroke-Acute Ischemic NXY Treatment (SAINT) I and SAINT II trials [PDF]

, 2009
<p><b>Background and Purpose:</b> A number of factors have been associated with postthrombolysis intracerebral hemorrhage, but these have varied across studies.</p> <p><b>Methods:</b> We examined patients with
Demchuk, A., Lees, K.R., Kasner, S.E., Messe, S.R., Cucchiara, B., Levine, S.R., Lyden, P., Sansing, L., Tanne, D.   +8 more
core   +1 more source