Results 51 to 60 of about 924,610 (305)

Dose escalation of desmoteplase for acute ischemic stroke (DEDAS): evidence of safety and efficacy 3 to 9 hours after stroke onset [PDF]

, 2006
<p><b>Background and Purpose:</b> Desmoteplase is a novel plasminogen activator with favorable features in vitro compared with available agents.
Lees, K.R., Hacke, W.l, Sachara, C., Rowley, H.A., Furlan, A.J., Al, R.Y., Eyding, D., Albers, G.W., Soehngen, M., Warach, S.   +9 more
core   +1 more source

Can the ischemic penumbra be identified on noncontrast CT of acute stroke? [PDF]

, 2007
<p><b>Background and Purpose:</b> Early ischemic changes on noncontrast CT in acute stroke include both hypoattenuation and brain swelling, which may have different pathophysiological significance.</p> <p><b>Methods:
Muir, K.W., McCormick, M., Baird, T., Coutts, S.B., Walker, L., Baird-Gunning, J.   +5 more
core   +1 more source

Relationship between hyperacute blood pressure and outcome after ischemic stroke: data from the VISTA Collaboration [PDF]

, 2009
Background and Purpose—High blood pressure (BP) is associated independently with poor outcome after acute ischemic stroke, although in most analyses “baseline” BP was measured 24 hours or more postictus, and not during the hyperacute period.
Bath, P.M.B., M. Ali, Sare, Gillian M., Bath, Philip M.W., P. M.W. Bath, Sare, G.M., Ali, M., Shuaib, A., Ali, Myzoon, null null, Shuaib, Ashfaq, A. Shuaib, G. M. Sare   +12 more
core   +1 more source

Safety and Effectiveness of a High‐Dose, Tailored Tissue Plasminogen Activator Therapy Protocol: A Joint Pediatric Hematology and Cardiac ICU Quality Improvement Initiative Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric thromboembolism is increasingly encountered in critical care. Systemic thrombolysis with tissue plasminogen activator (tPA) facilitates vessel or valve patency, yet pediatric‐specific protocols remain undefined, and safety concerns persist. Objective To evaluate the efficacy and safety of a tailored, prolonged systemic tPA
Eran Shostak, Oded Gilad, Yael Feinstein, Sigal Nakav, Ofer Schiller, Joanne Yacobovich   +5 more
wiley   +1 more source

The Predictive Value of Neurofilament Light Chain in Ischemic Stroke Severity and Short Term Outcome [PDF]

Zagazig University Medical Journal
:Background: Ischemic stroke is one of the most prevalent diseases affecting the brain with negative impact on quality of life, daily activity of ischemic stroke survivors, their families and society.
Rania Helal, Noha Sarhan, Sabah Fathy, Amany AbdAllah   +3 more
doaj   +1 more source

Prognostic factors of functional outcome in acute ischemic stroke [PDF]

, 2013
Trombolyse is een behandeling waarbij een stolsel in een bloedvat wordt opgelost door het gebruik van anti-bloedstollingsmiddelen. Irene Miedema deed onderzoek naar veiligheidsaspecten van trombolyse.
Miedema, Irene, Miedema, Irene,
core   +1 more source

Additional outcomes and subgroup analyses of NXY-059 for acute ischemic stroke in the SAINT I trial [PDF]

, 2006
<p><b>Background and Purpose:</b> NXY-059 is a free radical-trapping neuroprotectant demonstrated to reduce disability from ischemic stroke. We conducted analyses on additional end points and sensitivity analyses to confirm our findings.
Lees, K.R., Diener, H.-C., Shuaib, A., Zivin, J.A., Davis, S.M., Wasiewski, W., Lyden, P., Emeribe, U., Ashwood, T., Hardemark, H.G., Davalos, A., Grotta, J.   +11 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Proportions, trends, and outcomes of posterior circulation ischemic stroke in the United States

Frontiers in Neurology
BackgroundPosterior circulation ischemic stroke has been previously studied in single-center and multicenter registries. The contemporary proportions, trends, and outcomes of posterior circulation ischemic stroke at a national level are not known ...
Adnan I. Qureshi, Adnan I. Qureshi, Nived Jayaraj Ranjini, David Cohen, Shahhan Spall, Akash Roy, Christy N. Cassarly, Renee H. Martin, William J. Powers, Chun Shing Kwok   +9 more
doaj   +1 more source

Animal Models of Ischemic Stroke with Different Forms of Middle Cerebral Artery Occlusion

Brain Sciences, 2023
Ischemic stroke is a common type of stroke that significantly affects human well-being and quality of life. In order to further characterize the pathophysiology of ischemic stroke and develop new treatment strategies, ischemic stroke models with ...
Lang Zeng, Shengqi Hu, Lingcheng Zeng, Rudong Chen, Hua Li, Jiasheng Yu, Hongkuan Yang   +6 more
doaj   +1 more source