Results 171 to 180 of about 25,969 (255)

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Perceptual rhythms by phase-aligned perceptual performance peaks across trials. [PDF]

Commun Psychol
Schoeberl T, Treue S.
europepmc   +1 more source

Serotonin engages divergent 5‐HT receptor pathways for cell type‐resolved modulation of prefrontal layer 5 microcircuits

British Journal of Pharmacology, EarlyView.
Serotonin differentially modulates layer 5 mPFC microcircuits through cell type‐specific pre‐ and postsynaptic receptor pathways. Presynaptic 5‐HT1BRs suppress glutamate and GABA release, whereas presynaptic and postsynaptic 5‐HT3ARs enhance fast‐spiking interneuron activity, whilst distinct pyramidal neuron subtypes exhibit divergent 5‐HT1AR‐ and 5 ...
Ramya Rama, Guanxiao Qi, Gabriele Radnikow, Danqing Yang, Dirk Feldmeyer   +4 more
wiley   +1 more source

Inelastic Neutron Scattering Study of the Optically Excited State of MAPbBr₃. [PDF]

ACS Omega
Shi K, Cavaye H, Lavén R, Karlsson M.
europepmc   +1 more source

Cardiometabolic Risk in First Degree Relatives of Women With Polycystic Ovary Syndrome (PCOS)

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Polycystic ovary syndrome (PCOS) is a common multisystem disorder with reproductive, cardiometabolic and psychological implications. Genetic factors play a role in the pathogenesis of PCOS. We sought to investigate the cardiometabolic health of first degree relatives (FDR) of women with PCOS.
Su Jen Chua, Xinyi Wu, Tahani Al Kindi, Bulent O. Yildiz, Aya Mousa, Loyal Pattuwage, Helena Teede, Anju E. Joham, Chau Thien Tay   +8 more
wiley   +1 more source

Intermittent immunoadsorption in critically ill patients with neuroimmunological disorders: a retrospective study. [PDF]

Front Neurol
Wu Q, Zhu L, Dai S, Xu J, Ge D.
europepmc   +1 more source

Taxonomic and functional diversity of urban bees of the world

Conservation Biology, EarlyView.
Abstract Bees play a pivotal role in terrestrial environments. Urbanization can affect these organisms and the ecosystem services they provide. However, knowledge of the global diversity of urban bees is limited. Thus, we summarized data on urban bee species identities and occurrences; compared distributions of all bees with those found in urban ...
João C. F. Cardoso, Pietro K. Maruyama, Ingrid N. Gomes, Lorena B. Valadão‐Mendes, Victor H. D. Silva, Larissa Lorraine, Jordana O. Borges, Rogério V. Gonçalves, Léo C. Rocha‐Filho, Renata Trevizan, Yasmine Antonini   +10 more
wiley   +1 more source

Long-interval intracortical inhibition is similar in people with and without amyotrophic lateral sclerosis. [PDF]

Brain Commun
McMackin R, Tadjine Y, Suleyman N, Woods E, Plaitano S, Fasano A, Awiszus F, Hardiman O, Carson RG.   +8 more
europepmc   +1 more source

The Accuracy of Frozen Section Histopathology in the Rapid Diagnosis of Severe Cutaneous Adverse Reactions: A Systematic Review and Meta‐Analysis

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Frozen section analysis enables rapid diagnosis, but its diagnostic accuracy in the setting of severe cutaneous adverse reactions (SCARs) remains poorly defined. Methods A systematic review and meta‐analysis were performed to evaluate the diagnostic performance of frozen sections in the rapid identification of SCARs, with a focus on
Cody C. Frear, Louise Frear, Duncan Lambie, Amanda Godbolt   +3 more
wiley   +1 more source