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Transcriptional programs of infectious spleen and kidney necrosis virus (ISKNV) in vitro and in vivo
Virus Genes, 2020Infectious spleen and kidney necrosis virus (ISKNV), causing serious infectious diseases to marine and freshwater fishes, is the type species of the genus Megalocytivirus, family Iridoviridae. In this study, the transcriptional programs of ISKNV in vitro (MFF-1 cells) and in vivo (spleens from mandarin fish) were investigated using real-time PCR ...
Jian-hui He +5 more
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Journal of Fish Diseases, 2022
AbstractThe infectious spleen and kidney necrosis virus (ISKNV) is a highly lethal virus, which has brought significant losses to aquaculture. Therefore, a new vaccine against ISKNV with high efficiency, safety and convenience must be developed. While baculoviruses are more commonly used as protein expression systems for vaccine antigen production ...
Min Zhu +11 more
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AbstractThe infectious spleen and kidney necrosis virus (ISKNV) is a highly lethal virus, which has brought significant losses to aquaculture. Therefore, a new vaccine against ISKNV with high efficiency, safety and convenience must be developed. While baculoviruses are more commonly used as protein expression systems for vaccine antigen production ...
Min Zhu +11 more
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Genotype and host range analysis of infectious spleen and kidney necrosis virus (ISKNV)
Virus Genes, 2010Infectious spleen and kidney necrosis virus (ISKNV) is the causative agent of a disease causing high mortality in mandarin fish, Siniperca chuatsi. In this study, complete major capsid protein (MCP) genes of nine ISKNV isolates were sequenced and compared with other known megalocytiviruses to evaluate genetic variation and host range of the viruses ...
Xiaozhe, Fu +9 more
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2022
1ABSTRACTInfectious Spleen and Kidney Necrosis Virus (ISKNV) is increasingly gaining more attention globally, due to its highly significant economic impact on the aquaculture industry. In late 2018, unusually high levels of mortality (60-90%) was reported in some intensive tilapia cage culture systems in Ghana.
Angela Naa Amerley Ayiku +10 more
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1ABSTRACTInfectious Spleen and Kidney Necrosis Virus (ISKNV) is increasingly gaining more attention globally, due to its highly significant economic impact on the aquaculture industry. In late 2018, unusually high levels of mortality (60-90%) was reported in some intensive tilapia cage culture systems in Ghana.
Angela Naa Amerley Ayiku +10 more
openaire +1 more source
Virus Genes, 2007
Infectious spleen and kidney necrosis virus (ISKNV) is the type species of megalocytivirus, Iridoviridae. A novel membrane protein corresponding to the first open reading frame (ORF001L) of ISKNV genome was identified. This 378-residue protein, termed the VP001L protein, has a high content of hydrophobic sequences and contains 10-11 putative ...
Xiaopeng, Xu +5 more
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Infectious spleen and kidney necrosis virus (ISKNV) is the type species of megalocytivirus, Iridoviridae. A novel membrane protein corresponding to the first open reading frame (ORF001L) of ISKNV genome was identified. This 378-residue protein, termed the VP001L protein, has a high content of hydrophobic sequences and contains 10-11 putative ...
Xiaopeng, Xu +5 more
openaire +2 more sources
Transboundary and Emerging Diseases, 2020
Infectious spleen and kidney necrosis virus (ISKNV), a member of family iridoviridae, reported for the first time in a wide range of ornamental fish species in India. Significant mortalities during the year 2018-19 were reported from a number of retailers in the region with various clinical signs.
S. K. Girisha +9 more
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Infectious spleen and kidney necrosis virus (ISKNV), a member of family iridoviridae, reported for the first time in a wide range of ornamental fish species in India. Significant mortalities during the year 2018-19 were reported from a number of retailers in the region with various clinical signs.
S. K. Girisha +9 more
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Aquaculture, 2002
The pathogenicity of infectious spleen and kidney necrosis virus (ISKNV) was examined by infection trials in the first known host species, the mandarinfish, Siniperca chuatsi, and in 20 other teleosts cultured in China. Mandarinfish and large-mouth bass, Micropterus salmoides, were highly susceptible to infection after intraperitoneal infection of ...
J.G He, K Zeng, S.P Weng, S.-M Chan
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The pathogenicity of infectious spleen and kidney necrosis virus (ISKNV) was examined by infection trials in the first known host species, the mandarinfish, Siniperca chuatsi, and in 20 other teleosts cultured in China. Mandarinfish and large-mouth bass, Micropterus salmoides, were highly susceptible to infection after intraperitoneal infection of ...
J.G He, K Zeng, S.P Weng, S.-M Chan
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Virus Research, 2007
Infectious spleen and kidney necrosis virus (ISKNV) is the etiological agent that causes a pandemic and severe disease in fish characteristic of enlarged and damaged spleen and kidney. To identify viral proteins involved in infection and pathogenesis, we characterized five open reading frames (ORFs) of the ISKNV genome, ORF12, ORF65, ORF66, ORF99 and ...
Junfeng, Xie +8 more
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Infectious spleen and kidney necrosis virus (ISKNV) is the etiological agent that causes a pandemic and severe disease in fish characteristic of enlarged and damaged spleen and kidney. To identify viral proteins involved in infection and pathogenesis, we characterized five open reading frames (ORFs) of the ISKNV genome, ORF12, ORF65, ORF66, ORF99 and ...
Junfeng, Xie +8 more
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Fish & Shellfish Immunology, 2023
Type I interferons (IFNs) play a significant role in antiviral innate immunity. But, the antiviral function of IFNd is controversial in teleosts. Here, we identified three IFNd receptors belonging to cytokine receptor family B (LmCRFB1, LmCRFB2, and LmCRFB5) in spotted seabass (Lateolabrax maculatus).
Lulu, Yan +5 more
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Type I interferons (IFNs) play a significant role in antiviral innate immunity. But, the antiviral function of IFNd is controversial in teleosts. Here, we identified three IFNd receptors belonging to cytokine receptor family B (LmCRFB1, LmCRFB2, and LmCRFB5) in spotted seabass (Lateolabrax maculatus).
Lulu, Yan +5 more
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Developmental & Comparative Immunology, 2010
The interferon regulatory factor (IRF) family plays critical roles in a host's virus infection responses. In this study, two IRF family members, zfIRF5 and zfIRF7, are identified in zebrafish. The zfIRF5 protein encodes 297 amino acids without the carboxyl IRF3 domain.
Zhiming, Xiang +10 more
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The interferon regulatory factor (IRF) family plays critical roles in a host's virus infection responses. In this study, two IRF family members, zfIRF5 and zfIRF7, are identified in zebrafish. The zfIRF5 protein encodes 297 amino acids without the carboxyl IRF3 domain.
Zhiming, Xiang +10 more
openaire +2 more sources