Results 211 to 220 of about 2,821,777 (285)

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

Advanced Science, EarlyView.
The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia, Ying Cui, Jiongliang Wang, Wenjing Bai, Danyang Wang, Yao Chen, Huahui Guo, Liangyi Zong, Bing Qin, Xintong Cai, Jie Wang, Jing Huang, Scott B. Rothbart, Zufeng Guo, Stephen B. Baylin, Xiangqian Kong   +15 more
wiley   +1 more source

Somatic Growth Rates of Juvenile Green Sea Turtles (<i>Chelonia mydas</i>) in the Fijian Archipelago. [PDF]

Ecol Evol
Lemons GE, Turner Tomaszewicz CN, Prakash S, Miller K, Seminoff JA, Piovano S.   +5 more
europepmc   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Outcomes of Using Nasolabial Flap for Orofacial Reconstruction: A Retrospective Descriptive Case Series. [PDF]

Cureus
Murakami K, Minemura C, Morihara H, Nobuchi T, Toeda Y, Hirata Y, Yokoe H.   +6 more
europepmc   +1 more source

Pan‐3D Genome Analysis Reveals the Roles of Structural Variation in Chicken Chromatin Architectures, Domestication and Production Traits

Advanced Science, EarlyView.
This study firstly presents a comprehensive and high‐resolution pan‐3D genome resource in chicken. Our findings reveal the role of structural variations in 3D genome architectures, and how they influence the domestication process and production traits at the 3D genome level.
Zhen Zhou, Danfeng Cai, Changbin Zhao, Siyu Zhang, Jiahao Li, Zhaofeng Zhang, Shaofen Kong, Xin Yang, Xiaoli Zhou, Farhad Bordbar, Fayi Chen, Yaohuan Xu, Zhe Zhang, Lihong Gu, Zhenhui Li, Xiquan Zhang, Wen Luo, Jingting Shu, Bolin Cai, Qinghua Nie   +19 more
wiley   +1 more source

Trimethylamine N-oxide and related metabolites may regulate DNA methylation and trigger cardiovascular disease. [PDF]

Clin Epigenetics
Ma J, Lai CQ, Li XS, Wang M, Wang Z, Yao J, Guo X, Taylor KD, Lee S, Tracy RP, Peter D, Liu Y, Rotter JI, Rich SS, Budoff M, Tang W, DiDonato JA, Brody JA, Lemaitre RN, Fretts A, Sotoodehnia N, Psaty BM, Ordovás JM, Siscovick DS, Hazen SL, Mozaffarian D.   +25 more
europepmc   +1 more source

All Solid Lithium Metal‐Polymer Battery End‐of‐Life: an Investigation of Symmetric, Battery, and Bilayer Cells

Advanced Science, EarlyView.
In this study, the evolution of the lithium (Li)/polymer interface is compared in a realistic pouch cell configuration, either in Li/Li symmetric cell or in full Li/LiFePO4${\rm LiFePO}_4$ batteries thanks to X‐ray micro‐tomography. While Li/Li symmetric cells are the reference cell for probing the interface stability, results demonstrated that the end‐
Lucile Magnier, Didier Devaux, Jérôme Adrien, Ce Xiao, Philippe Dumaz, Margaud Lécuyer, Marc Deschamps, Eric Maire, Renaud Bouchet   +8 more
wiley   +1 more source

Lithography-free, site-controlled germanium quantum dots in silicon nanowires for single-hole transistors operating up to 50 K. [PDF]

Sci Adv
An J, Hu Z, He Z, Li S, Song X, Zhao L, Wang J, Yu L.   +7 more
europepmc   +1 more source

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

Advanced Science, EarlyView.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng, Shuang Cai, Chen Guo, Shaker Khan, Lefan Liu, Qiong Tian, Zhiyuan Ma, Jian Zhang, Lingyu Zhao   +8 more
wiley   +1 more source