Results 31 to 40 of about 2,816,162 (286)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Making Genus

Architecture Image Studies Scientific Journal, 2021
The ‘Making Genus’ project comes as a multi-faceted response to an unassuming, mono-directional quest – creating genderless utopia. Spanning across several mediums of expression such as graphics, the moving image and fiction writing, the work ...
Dariana Nistor
doaj   +1 more source

Enhancing the conductance of a two-electron nanomechanical oscillator

, 2008
We consider electron transport through a mobile island (i.e., a nanomechanical oscillator) which can accommodate one or two excess electrons and show that, in contrast to immobile islands, the Coulomb blockade peaks, associated with the first and second ...
A. Yu. Smirnov, Franco Nori, H. Park, J. R. Johansson, L. G. Mourokh   +4 more
core   +1 more source

How do individual cognitive differences relate to acceptability judgments?: A reply to Sprouse, Wagers, and Phillips [PDF]

, 2012
Sprouse, Wagers, and Phillips (2012) carried out two experiments in which they measured individual differences in memory to test processing accounts of island effects. They found that these individual differences failed to predict the magnitude of island
Casasanto, Laura Staum, Hofmeister, Philip, Sag, Ivan A   +2 more
core   +1 more source

Understanding “Islandness”

Annals of the American Association of Geographers, 2023
Islandness is a contested concept, not just between disciplines but also cultures, entangled with what islands, island studies, and island identity are understood to be. The purpose of this article is to explore some of these different meanings, without necessarily unifying or reconciling them, with the aim of keeping multiple understandings of ...
Aideen Foley, Laurie Brinklow, Jack Corbett, Ilan Kelman, Carola Klöck, Stefano Moncada, Michelle Mycoo, Patrick Nunn, Jonathan Pugh, Stacy-ann Robinson, Verena Tandrayen-Ragoobur, Rory Walshe   +11 more
openaire   +4 more sources

Basilar Artery Occlusion Stroke Managed With Tenecteplase Versus Alteplase Before Endovascular Treatment (BAO‐TNK)

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To compare the effectiveness and safety of tenecteplase (TNK) versus alteplase (TPA) in patients with basilar artery occlusion prior to endovascular treatment (EVT). Methods In this retrospective multicenter study (BAO‐TNK), we analyzed consecutive BAO patients from 14 U.S.
Rahul R. Karamchandani, Dylan N. Wolman, Tyler M. Bielinski, Nitin Goyal, Jeremy B. Rhoten, Mahesh V. Jayaraman, Christian T. Sidebottom, Bradley A. Gross, Alhamza R. Al‐Bayati, Mohamed F. Doheim, Matthew K. Tobin, Anoop Chinthala, Avi Gajjar, Justin Mascitelli, Matthew R. Webb, Jan‐Karl Burkhardt, Kyle W. Scott, Visish Srinivasan, Daniel Tonetti, Manisha Koneru, David J. Altschul, Dhrumhil Vaishnav, Sumeet Multani, Thana Theofanis, William J. Ares, Je Yeong Sone, Ramin Zand, Sasan Bahrami, Jiang Li, Gary Defilipp, Dale Strong, Radmehr Torabi, Krisztina Moldovan, Kelsey E. Kline, Clemens M. Schirmer, Raul G. Nogueira, Alexandra R. Paul, Bradley N. Bohnstedt, Philipp Hendrix   +38 more
wiley   +1 more source

Notes for an Island

Architecture Image Studies Scientific Journal, 2021
This text offers a writerly experiment aimed at developing a possible method of critical speculative fiction. The subject is an imaginary island modelled on the Cycladic island of Amorgos, Greece, which is depicted here as an all-encompassing design ...
Marko Jobst
doaj   +1 more source

Island Transport Challenges: Four Island Jurisdictions; Seven Island Perspectives

Island Studies Journal
Island transport systems are as unique as the islands themselves, shaped by geography, politics, and community needs. Transport development raises key questions: does increased connectivity enhance or diminish islandness? Can large-scale projects balance economic goals with environmental sustainability and community needs?
Abraham Leung, Stefan Baumeister
openaire   +4 more sources

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source