Results 31 to 40 of about 342 (231)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
What the sea portends: a reconsideration of contested island tropes [PDF]
Island Studies Journal, 2013 This paper argues for a shift in the focus of island-themed scholarship away from theories of islandness toward an engagement with psychologies of island experience. The former project has become mired in intractable dilemmas.
Pete Hay
doaj +2 more sources
Island Studies JournalOn Taiwan’s offshore islands of Kinmen, the water supply infrastructure has experienced various challenges stemming from the physical and social conditions of islands.
Mei-Huan Chen
doaj +1 more source
Island Studies. Island Geography. but What is an Island? [PDF]
Miscellanea Geographica, 2011 Island Studies. Island Geography. but What is an Island? Introduction. There are institutes which research phenomena and processes taking place on islands. Such research is conducted nowadays among others at universities in France, United States, Australia, New Zealand, Great Britain and ...
openaire +2 more sources
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Il discorso dell’anti-insularità e il poio maderense come sua negazione [PDF]
Diacronie. Studi di Storia Contemporanea, 2016 The Madeirans put the idea of the island as a center of the world before the smallness of geographic space: in this way they claim its anti-insularity point of view. The reality, therefore, determines its opposite.
Alberto Vieira
doaj
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Water Administration in Mayotte: Islandness in a French Overseas Department
Island Studies JournalThis paper explores the impacts of prolonged drought in Mayotte, a French Overseas Department in the southwestern Indian Ocean. The study examines how islandness, characterized by notions of smallness, boundedness, and remoteness, shapes local discourses,
Gaia Olivero Fugera
doaj +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source