Results 51 to 60 of about 1,966 (269)

Island Transport Challenges: Four Island Jurisdictions; Seven Island Perspectives

Island Studies Journal
Island transport systems are as unique as the islands themselves, shaped by geography, politics, and community needs. Transport development raises key questions: does increased connectivity enhance or diminish islandness? Can large-scale projects balance economic goals with environmental sustainability and community needs?
Abraham Leung, Stefan Baumeister
openaire   +4 more sources

Islandness and remoteness as resources : evidence from the tourism performance of small remote island economies (SRIES) [PDF]

, 2011
Small remote island economies are known to face a number of economic challenges, particularly, in their trade relations. This paper investigates the impact of remoteness and islandness on tourism performance. Remote islands are found to be well‑endowed
Sufrauj, Shamnaaz
core   +1 more source

Bursting the bubble : the pseudo- development strategies of microstates [PDF]

, 1993
Developing microstates are bountiful on the world political map today. Yet the concept of smallness, apart from being relativistic, conjures up a sense of deviation, indicative of a subtle discrimination which implicitly takes large to be normal and ...
Baldacchino, Godfrey
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Malapportionment as a Factor Associated With Islandness: Three Archipelagos Compared

Island Studies Journal
This study examines the relationship between malapportionment and islandness in three European archipelagos (Canary Islands, Balearic Islands, Azores), employing a comparative analysis of electoral systems.
Miguel Carranza Guasch
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Island refuge [PDF]

Current Biology, 2009
SummaryAn artificial island in eastern Turkey created by a team of biologists is proving a haven for wildlife. Nigel Williams reports.
openaire   +2 more sources

Solving problems, the island way : human resourcefulness in action among the islanders of Gozo [PDF]

, 2015
This paper offers glimpses into how businesspersons, entrepreneurs and small business managers resolve their most pressing problems under conditions characterized by smallness and islandness in order to survive.
Azzopardi, Joseph G.
core   +1 more source

Cutaneous Phosphorylated Alpha‐Synuclein in Lewy Body Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the test performance of cutaneous phosphorylated alpha‐synuclein (P‐SYN) in dementia with Lewy bodies (DLB), individuals with reduced Montreal Cognitive Assessment (MoCA) and healthy controls. Methods This is the first subgroup analysis of the Synuclein‐One study, a prospective, blinded study evaluating P‐SYN detection ...
Christopher H. Gibbons, Todd Levine, Charles H. Adler, Bailey Bellaire, Ningshan Wang, Pinky Agarwal, Georgina M. Aldridge, Alexandru Barboi, Daniel Claassen, Virgilio G. H. Evidente, Douglas Galasko, Alejandra Gonzalez‐Duarte, Ramon Gil, Mark Gudesblatt, Stuart H. Isaacson, Horacio Kaufmann, Pravin Khemani, Rajeev Kumar, Guillaume Lamotte, Andy J. Liu, Nikolaus R. McFarland, Mitchell G. Miglis, Adam Reynolds, Gregory A. Sahagian, Marie‐Helene Saint‐Hilaire, Julie B. Schwartzbard, Wolfgang Singer, Michael J. Soileau, Steven Vernino, Patricio Millar Vernetti, Oleg Yerstein, Roy Freeman   +31 more
wiley   +1 more source