Results 41 to 50 of about 1,921 (247)

Six-proposition manifesto for small Island territories [PDF]

open access: yes, 2000
Conventional wisdom suggests that small, often island, states are more likely than larger nations to be hard hit by the effects of national disasters, of fluctuations in the global economy, and the political aspirations of world powers.
Baldacchino, Godfrey
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Bounded by heritage and the Tamar: Cornwall as ‘almost an island’

open access: yesIsland Studies Journal, 2020
This article considers the manner in which the English county of Cornwall has been imagined and represented as an island in various contemporary contexts, drawing on the particular geographical insularity of the peninsular county and distinct aspects of ...
Philip Hayward, Christian Fleury
doaj   +1 more source

How far can one go? : how distance matters in island development [PDF]

open access: yes, 2020
Island development trajectories are heavily impacted by their relevance, similarity, complementarity and value in relation to continental development pathways.
Baldacchino, Godfrey
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Il discorso dell’anti-insularità e il poio maderense come sua negazione [PDF]

open access: yesDiacronie. Studi di Storia Contemporanea, 2016
The Madeirans put the idea of ​​the island as a center of the world before the smallness of geographic space: in this way they claim its anti-insularity point of view. The reality, therefore, determines its opposite.
Alberto Vieira
doaj  

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Islandness and remoteness as resources : evidence from the tourism performance of small remote island economies (SRIES) [PDF]

open access: yes, 2011
Small remote island economies are known to face a number of economic challenges, particularly, in their trade relations. This paper investigates the impact of remoteness and islandness on tourism performance. Remote islands are found to be well‑endowed
Sufrauj, Shamnaaz
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Understanding Islandness Effects Through the Challenges of Water Infrastructure: A Case Study on the Kinmen Islands

open access: yesIsland Studies Journal
On Taiwan’s offshore islands of Kinmen, the water supply infrastructure has experienced various challenges stemming from the physical and social conditions of islands.
Mei-Huan Chen
doaj   +1 more source

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