Results 51 to 60 of about 1,151,315 (325)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
What the sea portends: a reconsideration of contested island tropes [PDF]
Island Studies Journal, 2013 This paper argues for a shift in the focus of island-themed scholarship away from theories of islandness toward an engagement with psychologies of island experience. The former project has become mired in intractable dilemmas.
Pete Hay
doaj +2 more sources
Social SciencesIslands and island communities are often perceived as homogenous in mainstream discourse. While many islands share characteristics, such as smallness or isolation, these are experienced differently across and within island contexts and intersect with ...
Sissal Dahl +3 more
doaj +1 more source
Issues and Tensions in Island Heritage Management: A Case Study of Motuihe Island, New Zealand [PDF]
Island Studies Journal, 2010 This paper draws on a New Zealand case study, Motuihe Island, to examine the challenges of conserving cultural heritage in places renowned for natural heritage values.
David Bade
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Islands within an almost island: History, myth, and aislamiento in Baja California, Mexico [PDF]
, 2016 This paper examines the persistent histories and lasting effects of the Baja California peninsula\u27s status as an almost island. The peninsula is almost an island in so many ways. Its reputation as an island-like entity has also ben strengthened by a
Anderson, Ryan B.
core +1 more source
Six-proposition manifesto for small Island territories [PDF]
, 2000 Conventional wisdom suggests that small, often island, states are more likely than larger nations to be hard hit by the effects of national disasters, of fluctuations in the global economy, and the political aspirations of world powers.
Baldacchino, Godfrey
core +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Bounded by heritage and the Tamar: Cornwall as ‘almost an island’
Island Studies Journal, 2020 This article considers the manner in which the English county of Cornwall has been imagined and represented as an island in various contemporary contexts, drawing on the particular geographical insularity of the peninsular county and distinct aspects of ...
Philip Hayward, Christian Fleury
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Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Il discorso dell’anti-insularità e il poio maderense come sua negazione [PDF]
Diacronie. Studi di Storia Contemporanea, 2016 The Madeirans put the idea of the island as a center of the world before the smallness of geographic space: in this way they claim its anti-insularity point of view. The reality, therefore, determines its opposite.
Alberto Vieira
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