Results 131 to 140 of about 6,756 (199)

Bioengineering of a human iPSC-derived vascularized endocrine pancreas for type 1 diabetes. [PDF]

Cell Rep Med
Campo F, Neroni A, Pignatelli C, Pellegrini S, Marzinotto I, Valla L, Manenti F, Policardi M, Lampasona V, Piemonti L, Citro A.   +10 more
europepmc   +1 more source

Transplantation of isologous islets of langerhans in diabetic rats [PDF]

Acta Diabetologica Latina, 1975
Isologous isolated islets of Langerhans were transplanted into the peritoneum and, via the portal vein, into the liver of diabetic rats. In both groups almost normal blood glucose and serum insulin levels were achieved for a period of three months. Glucose tolerance tests were markedly improved.
Klaus-Dieter Rosenbaum, J. Petermann, Ruthard Beckert, Alfred Dorn, Lorenz D, Manfred Ziegler   +5 more
openaire   +3 more sources

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Isolation of human and porcine islets of langerhans and islet transplantation in pigs

Journal of Surgical Research, 1974
Abstract Using a modification of the collagenase digestion, Ficoll gradient separation technique, we isolated the islets of Langerhans from fresh human pancreata removed from braindead cadavers. Comparison of the tissue insulin/amylase ratios between whole pancreas and isolated material revealed a significant purification of islet from acinar tissue.
Darlene McManus, David E.R. Sutherland, Michael W. Steffes, G. Eric Bauer, John S. Najarian, Bran D. Noe   +5 more
openaire   +4 more sources

Transplantation of Islets of Langerhans into the Anterior Chamber of the Eye for Longitudinal In Vivo Imaging

Methods in molecular biology, 2020
Noninvasive in vivo imaging techniques are attractive tools to longitudinally study various aspects of islet of Langerhans physiology and pathophysiology. Unfortunately, most imaging modalities currently applicable for clinical use do not allow the comprehensive investigation of islet cell biology due to limitations in resolution and/or sensitivity ...
Christian M. Cohrs, Chunguang Chen, Stephan Speier   +2 more
openaire   +4 more sources

Effect of Antithymocyte Globulin on Islet of Langerhans Transplantation

Nephron, 1978
Lewis rats were treated with streptozotocin to induce hyperglycemia and glycosuria (400-600 mg/dl). Transplantation of approximately 1,000 dissociated islets obtained from collagenase-treated pancreases from 4 donors will promptly correct induced diabetes.
Eli A. Friedman, Monica M. Beyer
openaire   +4 more sources

Islet of Langerhans Transplantation for the Treatment of Type 1 Diabetes

Swiss Surgery, 2003
Islet of Langerhans transplantation is gaining recognition as a therapy for type 1 diabetes. The procedure involves enzymatic digestion of the pancreatic tissue, purification of the islets from the exocrine tissue, infusion of the islets into the portal vein and implantation in the liver.
Bucher, Pascal Alain Robert, Mathe, Z, Bosco, Domenico, Andres, Axel, Buehler, Leo Hans, Morel, Philippe, Berney, Thierry   +6 more
openaire   +5 more sources

The role of histocompatibility antigens in transplantation of isolated islets of Langerhans in the rat

Diabetes, 1993
In a model of congenic and intra-MHC recombinant rat strains, the differential role of various histocompatibility antigens in renal subcapsular transplantation of purified islets of Langerhans isevaluated. Class I MHC antigens of the RT1.A region, expressed on the endocrine cells of the islets themselves, do not induce graft rejection on their own. MHC
Jürgen Klempnauer, W. F. A. Hiller, Steiniger B   +2 more
openaire   +4 more sources

Damage to porcine islets of Langerhans after exposure to human blood in vitro, or after intraportal transplantation to cynomologus monkeys: protective effects of sCR1 and heparin.

Transplantation, 2000
BACKGROUND Porcine islets offer an attractive alternative to human islets in clinical islet transplantation. The preferred method of islet transplantation is intra-portal injection into the liver.
W. Bennet, B. Sundberg, T. Lundgren, A. Tibell, C. Groth, A. Richards, D. White, G. Elgue, R. Larsson, B. Nilsson, O. Korsgren   +10 more
semanticscholar   +2 more sources

Transplantation of the Islets of Langerhans and the Histocompatibility of Endocrine Tissue

Diabetes, 1975
The passing of Dr. Arnold Lazarow on June 26 was a loss to the science of diabetology. Dr. Lazarow, Professor and Chairman of the Department of Anatomy, University of Minnesota School of Medicine, Minneapolis, was Codirector of the Twelfth Research Symposium of the American Diabetes Association and Chairman of one of the three sessions. As a tribute to
C. Barker
openaire   +4 more sources

Transplantation of isolated islets of langerhans in diabetic dogs. I. Results after allogeneic intraportal islet transplantation

Journal of Surgical Research, 1979
Abstract Twenty partially inbred German shepherd dogs were made diabetic by intravenous administration of streptozotocin (25 mg/kg) 1 and 3 days after partial pancreatectomy. Ten diabetic dogs received intraportal transplants of allogeneic islets of Langerhans isolated by collagenase digestion and Ficon gradient separation.
K D Rosenbaum, Lippert H, Manfred Ziegler, A. Dorn, D. Lorenz, Hans-Jürgen Hahn, V. Worm, W. Tietz, G. Koch   +8 more
openaire   +4 more sources