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[Transplantation of islets of Langerhans in man].

Helvetica chirurgica acta, 1993
Islet of Langerhans transplantation is an alternative to whole pancreas transplantation for type I diabetic patients, in whom exogenous insulin therapy has not prevented the occurrence of systemic complications. Thanks to a new isolation technique of human islets, 45 patients have been transplanted worldwide since 1988, of whom only 7 have become ...
P H, Morel, L, Bühler, M, Marini, S, Deng, R, Mage, G, Mentha, A, Rohner   +6 more
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Multiple Transplantations of Islets of Langerhans

European Surgical Research, 1977
In 6 diabetic rats about 1,000 isolated islets of Langerhans were transplanted into the liver with little effect on the uninsulinism and hyperglycemia. Subsequently, a second transplantation resulted in a decrease of blood sugar to normal and in a reversal of the loss in body weight. Finally, in animals who had reversed to diabetes again, a third islet
K D, Rumpf, D, Löhlein, , Pichlmayr
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Culture of the islets of Langerhans for transplantation

The Japanese Journal of Surgery, 1982
The isolated islets of Langerhans are the most available donors for transplantation. As the preservation of the isolated islets is difficult, we attempted to keep these tissues viable by use of an organ culture. Islets of Langerhans from adult Wistar rats were isolated by a collagenase technique and cultured in air-CO2 (95-5%) incubator at 37 degrees C.
Y, Kojima, G, Nakagawara, I, Miyazaki
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Bovine Islets of Langerhans: Potential Source for Transplantation?

Diabetes, 1989
Two methods are described for large-scale isolation of islets from the bovine pancreas. With the single-endpoint technique the average number of islets isolated from a 73.3-g pancreas sample was 150,560, representing an estimated total islet volume of 0.391 ml. Pancreases processed by the continuous digestion-filtration method yielded an average of 246,
B J, Hering, D, Romann, A, Clarius, M, Brendel, M, Slijepcevic, R G, Bretzel, K, Federlin   +6 more
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Suppression, Stress, and Accommodation of Transplanted Islets of Langerhans

Diabetes, 1985
Successful intrasplenic islet autotransplantation in dogs requires an islet cell mass considerably greater than what might be expected based on studies of subtotal pancreatectomy. Grafts of marginal function ultimately fail, suggesting severe limitations in the capacity of an islet graft to adapt.
R C, Merrell, M, Maeda, G, Basadonna, F, Marincola, L, Cobb   +4 more
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[Transplantation of islets of Langerhans].

Nederlands tijdschrift voor geneeskunde, 1989
R O, Gans, H J, Bilo
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Transplantation of islets of Langerhans

Journal of Hepato-Biliary-Pancreatic Surgery, 1994
The present study attempts to evaluate the possibility of using cryopreserved pancreatic islets in rats. Insulin-releasing activity was studied for the purpose of clarifying the function of cryopreserved islets. Cryopreserved pancreatic islets were also transplanted into the portal veins of recipient rats.
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Transplantation of isologous islets of langerhans in diabetic rats

Acta Diabetologica Latina, 1975
Isologous isolated islets of Langerhans were transplanted into the peritoneum and, via the portal vein, into the liver of diabetic rats. In both groups almost normal blood glucose and serum insulin levels were achieved for a period of three months. Glucose tolerance tests were markedly improved.
D, Lorenz, K D, Rosenbaum, J, Petermann, M, Ziegler, R, Beckert, A, Dorn   +5 more
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Effect of Antithymocyte Globulin on Islet of Langerhans Transplantation

Nephron, 1978
Lewis rats were treated with streptozotocin to induce hyperglycemia and glycosuria (400-600 mg/dl). Transplantation of approximately 1,000 dissociated islets obtained from collagenase-treated pancreases from 4 donors will promptly correct induced diabetes.
E A, Friedman, M M, Beyer
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[Islet of Langerhans transplantation].

Annales de chirurgie, 1996
Islet of Langerhans transplantation is considered to be the ideal treatment for type I insulin-dependent diabetes. The permanent and adapted insulin secretion obtained by this method ensures prevention or even regression of the degenerative lesions which now constitute the severity of this frequent disease.
K, Boudjema, E, Alexandre
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