Results 181 to 190 of about 5,911 (222)

Islet transplantation. The connection of experiment and clinic exemplified by the transplantation of islets of Langerhans.

Experimental and clinical endocrinology, 1994
Since approximately 25 years islet transplantation as a mean for the treatment of diabetes has been developed from early attempts in rodents to first clinical applications in man in recent years. The review describes the results obtained in diabetic rats including metabolic effects as well as prevention of late complications.
openaire   +2 more sources

[Transplantation of islets of Langerhans: procedure, indications and challenges].

Nederlands tijdschrift voor geneeskunde, 2018
Pancreatic islet isolation and transplantation are complicated procedures, indicated for a carefully selected group of patients. After isolation from the pancreas, the islets are infused into the portal vein. Allogeneic islet transplantation is performed in patients with diabetes mellitus, who suffer from severe hypoglycaemic events and/or progressive ...
M F, Nijhoff, V A L, Huurman, J, Dubbeld, A R, van Erkel, T A, Rabelink, M A, Engelse, E J P, de Koning   +6 more
openaire   +1 more source

Transplantation of islets of Langerhans in millipore diffusion chambers.

Transplantation proceedings, 1990
S, Jäger, M D, Menger, W, Göhde, H, Themann   +3 more
openaire   +2 more sources

[Islets of langerhans and pancreas transplantation tomorrow].

Diabete & metabolisme, 1995
Pancreatic tissue grafting as a substitution for insulin deficiency of diabetes is by far the most physiological therapeutic approach of the disease. Both islets and pancreatic gland have been successfully implanted in experimental animal diabetes and in patients, resulting in full normalisation of glucose homeostasis and, in animals, prevention of ...
openaire   +1 more source

Transplantation of islets of Langerhans in diabetic rhesus monkeys.

Surgery, 1975
Islets of Langerhans from unrelated donor rhesus monkeys were transplanted into the portal vein of five rhesus monkeys which had been made diabetic by partial pancreatectomy and Streptozotocin. There was definite improvement of the diabetic state with an increase in the mean KT1/2 from 0.71 to 1.52 percent per minute. The islets were isolated by a more
D W, Scharp, J J, Murphy, W T, Newton, W F, Ballinger, P E, Lacy   +4 more
openaire   +1 more source

Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates

Nature Medicine, 2022
Yuanyuan Du, Shu-Sen Wang, Soon Yi Liew
exaly  

Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells

Nature Biotechnology, 2022
Diego Balboa, Tom Barsby, Väinö Lithovius   +2 more
exaly  

Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes

Nature Metabolism, 2022
Gregory W Schwartz, Abhijeet R Patil, Aanchal Mongia   +2 more
exaly  

The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets

Nature Metabolism, 2023
Kimberley El, Francis S Willard, Aaron Novikoff   +2 more
exaly  

The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides

Nature Immunology, 2020
Xiaoxiao Wan, Cheryl F Lichti, Emil R Unanue   +2 more
exaly