Results 31 to 40 of about 3,658 (149)

Practical considerations for pathologists when selecting digital pathology systems: an ESDIP guide

The Journal of Pathology, EarlyView.
Abstract The implementation of digital pathology (DP) has been reported across academic, public, and private laboratory settings, providing valuable insights into workflow transformation. However, comparatively little guidance exists on how DP systems should be evaluated prior to acquisition and deployment.
Diana Montezuma, Vincenzo L'Imperio, David Ameisen, Rita Carvalho, Peter Boor, Sara P Oliveira, Nadieh Khalili, Inti Zlobec, Norman Zerbe, Jordi Temprana‐Salvador   +9 more
wiley   +1 more source

ISO 15189 accreditation: enhancing laboratory performance, safety, and personnel competence

Journal of Laboratory Medicine
ISO 15189 accreditation provides a structured framework to ensure quality and reliability in clinical laboratories. Evidence from multiple international settings demonstrates that implementing ISO 15189–based quality management systems (QMS) can ...
Takahashi Shinichiro
doaj   +1 more source

Capacitación única y cumplimiento de requisitos técnicos ISO 15189 en laboratorio clínico hospitalario, Ecuador

Hacia la Promoción de la Salud
Introducción: La acreditación ISO 15189 garantiza resultados analíticos técnicamente válidos y comparables; imprescindible en la seguridad y calidad de vida del paciente, sin embargo, no muchos laboratorios clínicos han conseguido acreditar.
Elizabeth del Rocío Escudero-Vilema, Rosario de los Angeles Montaguano-Masaquiza, Adriana Carolina Rincón-Alarcón, Paola Alejandra Villalón-Muñoz, Mónica Jimena Concha-Guailla   +4 more
doaj   +1 more source

Bone progression in multiple myeloma: Benefit of zoledronic acid for patients achieving at least Very Good Partial Response and prognostic value of bone turnover markers

British Journal of Haematology, EarlyView.
Summary The Magnolia study demonstrated that continuation of zoledronic acid (ZOL) beyond 2 years reduces the risk of progressive bone disease (PBD) in patients with multiple myeloma (MM). This follow‐up study investigated the effects of ZOL in patients achieving very good partial response (VGPR) compared to patients who did not and whether bone ...
Michael Tveden Gundesen, Annette Juul Vangsted, Carsten Helleberg, Einar Haukås, Trine Silkjær, Jonna Skov Madsen, Jon Thor Asmussen, Elena Manuela Teodorescu, Bo Amdi Jensen, Tobias Schmidt Slørdahl, Aneta Alexandra Nielsen, Dorte Aalund Olsen, Kent Søe, Hareth Nahi, Anders Waage, Niels Abildgaard, Fredrik Schjesvold, Thomas Lund   +17 more
wiley   +1 more source

Biochemical profiling and symptomatology of androgen deficiency in males with cluster headache: A prospective case–control study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background Cluster headache (CH) has historically been considered a male‐dominated disorder, suggesting a role for androgens in its pathophysiology. We aimed to evaluate hormone profiles and symptoms of androgen deficiency in CH.
Willemijn C. Naber, Roemer B. Brandt, Mariël Leon Morales‐Grooters, Ronald van der Wal, Sjoerd A. A. van den Berg, Jelle J. Goeman, Antoinette Maassen van den Brink, Rolf Fronczek   +7 more
wiley   +1 more source

The SLMTA programme: Transforming the laboratory landscape in developing countries

African Journal of Laboratory Medicine, 2014
Background: Efficient and reliable laboratory services are essential to effective and well-functioning health systems. Laboratory managers play a critical role in ensuring the quality and timeliness of these services.
Katy Yao, Talkmore Maruta, Elizabeth T. Luman, John N. Nkengasong   +3 more
doaj   +3 more sources

Different Analytical Modes on Automatic Hematology Analyzers for Testing Quality Control Materials and Commutability Assessment

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Hematological disorders, critical for diagnosis, and monitoring, rely on accurate complete blood count results from automated analyzers, the reliability of which depends on robust quality control (QC). However, the ability of commutability of commercial hematology QC materials (HQCM) to behave like patient samples across different
Bingshuang Ren, Ya Cheng, Hongping Ba, Weijia Cheng, Xuwei Zhou, Hui Zhen, Shimin Wu, Jie Gong   +7 more
wiley   +1 more source

Transcranial Magnetic Stimulation as a Translational Biomarker in Early‐Phase Anti‐Seizure Medication Development: A Randomized, Double‐Blind, Placebo‐Controlled Study in Generalized Epilepsy

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 673-683, September 2026.
One‐third of epilepsy patients remain treatment‐resistant, underscoring the need for novel anti‐seizure medications (ASMs) and reliable biomarkers of central target engagement. Cortical hyperexcitability is a hallmark of epilepsy, making excitability a valuable pharmacodynamic biomarker for early‐phase drug development supporting go/no‐go decision ...
Catherine M. E. de Cuba, Titia Q. Ruijs, Annika A. de Goede, Robert J. Doll, Maria Juachon, Michel J. A. M. van Putten, Geert Jan Groeneveld, Jules A. A. C. Heuberger   +7 more
wiley   +1 more source

Limited Utility of a Test‐Yolk Buffer Semen Extender for Preserving Human Semen Parameters for Use in a Diagnostic Setting

Andrology, Volume 14, Issue 6, Page 1701-1711, September 2026.
ABSTRACT Background Identification of a preservation medium that accurately retains semen parameters would be advantageous for men requiring semen analysis by allowing them to produce sperm samples at home rather than on site or even facilitate ‘mail order’ semen analysis.
Alessia Schadwell, Andrew Dawkins, Tina Holton, Olivia Whiting, Peter J. I. Ellis, Sheryl T. Homa   +5 more
wiley   +1 more source

Mutational Signature‐Based Biomarker for Phase II Trial of Olaparib Maintenance in Advanced High‐Grade Ovarian Cancer

Cancer Science, Volume 117, Issue 8, Page 2259-2273, August 2026.
A whole‐exome sequencing–based mutational signature biomarker (MSBM) identified an HRD‐enriched population in advanced ovarian cancer. In a phase II trial, olaparib maintenance suggested clinically meaningful PFS benefit without bevacizumab, supporting MSBM as a complementary HRD assessment approach.
Katsutoshi Oda, Daisuke Shintani, Akira Nishijima, Mayuyo Mori, Kazuyoshi Kato, Shoji Nagao, Noriomi Matsumura, Masahiro Kagabu, Masataka Takenaka, Kosuke Yoshihara, Yosuke Konno, Junzo Hamanishi, Sho Sato, Shiro Takamatsu, Keiko Ueda, Kosuke Kashiwabara, Takashi Aoki, Kunihiro Nishimura, Kenji Tatsuno, Hiroyuki Aburatani, Kosei Hasegawa   +20 more
wiley   +1 more source