Results 41 to 50 of about 4,435 (200)

Mutational Signature‐Based Biomarker for Phase II Trial of Olaparib Maintenance in Advanced High‐Grade Ovarian Cancer

Cancer Science, EarlyView.
A whole‐exome sequencing–based mutational signature biomarker (MSBM) identified an HRD‐enriched population in advanced ovarian cancer. In a phase II trial, olaparib maintenance suggested clinically meaningful PFS benefit without bevacizumab, supporting MSBM as a complementary HRD assessment approach.
Katsutoshi Oda, Daisuke Shintani, Akira Nishijima, Mayuyo Mori, Kazuyoshi Kato, Shoji Nagao, Noriomi Matsumura, Masahiro Kagabu, Masataka Takenaka, Kosuke Yoshihara, Yosuke Konno, Junzo Hamanishi, Sho Sato, Shiro Takamatsu, Keiko Ueda, Kosuke Kashiwabara, Takashi Aoki, Kunihiro Nishimura, Kenji Tatsuno, Hiroyuki Aburatani, Kosei Hasegawa   +20 more
wiley   +1 more source

Biochemical profiling and symptomatology of androgen deficiency in males with cluster headache: A prospective case–control study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background Cluster headache (CH) has historically been considered a male‐dominated disorder, suggesting a role for androgens in its pathophysiology. We aimed to evaluate hormone profiles and symptoms of androgen deficiency in CH.
Willemijn C. Naber, Roemer B. Brandt, Mariël Leon Morales‐Grooters, Ronald van der Wal, Sjoerd A. A. van den Berg, Jelle J. Goeman, Antoinette Maassen van den Brink, Rolf Fronczek   +7 more
wiley   +1 more source

The SLMTA programme: Transforming the laboratory landscape in developing countries

African Journal of Laboratory Medicine, 2014
Background: Efficient and reliable laboratory services are essential to effective and well-functioning health systems. Laboratory managers play a critical role in ensuring the quality and timeliness of these services.
Katy Yao, Talkmore Maruta, Elizabeth T. Luman, John N. Nkengasong   +3 more
doaj   +3 more sources

Reproducible Data Analysis With R in Laboratory Hematology

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Laboratory hematology generates large, complex datasets that increasingly exceed the capabilities of traditional spreadsheet‐based analytical workflows. Despite their familiarity, spreadsheets obscure analytical logic, encourage manual data manipulation, and lack durable records of analytical steps, limiting transparency, auditability, and ...
Amrom E. Obstfeld
wiley   +1 more source

Забезпечення якості послуг медичної лабораторії відповідно до вимог ДСТУ EN ISO 15189:2015

, 2023
Розроблення пропозицій щодо вдосконалення процесів забезпечення якості ДУ «Дніпропетровський ОЦКПХ МОЗ України на основі міжнародного стандарту ДСТУ EN ISO 15189 ...
Коваль, Вадим Васильович
core   +1 more source

Development and implementation of the Caribbean Laboratory Quality Management Systems Stepwise Improvement Process (LQMS-SIP) Towards Accreditation

African Journal of Laboratory Medicine, 2017
Background: Implementing quality management systems and accrediting laboratories in the Caribbean has been a challenge. Objectives: We report the development of a stepwise process for quality systems improvement in the Caribbean Region.
George Alemnji, Lisa Edghill, Giselle Guevara, Sacha Wallace-Sankarsingh, Rachel Albalak, Sebastien Cognat, John Nkengasong, Jean-Marc Gabastou   +7 more
doaj   +1 more source

HLA genotype testing for carbamazepine, oxcarbazepine and eslicarbazepine: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 1957-1976, July 2026.
Carbamazepine is licensed in the United Kingdom for the treatment of epilepsy, bipolar disorder and trigeminal neuralgia. The related compounds oxcarbazepine and eslicarbazepine are licensed for the treatment of epilepsy. These drugs can cause immune‐mediated hypersensitivity reactions, which typically affect the skin, and can be of variable severity ...
Lucy Galloway, Cinzia Dello Russo, Nicholas Bass, Elvira Bramon, Helen Cross, Natalie Curley, Sarah Curran, Helen Davies, Jana De Villiers, William Evans, Bernhard Frank, Alice Groves, Judith Hayward, Jon Higham, Dyfrig A. Hughes, Shwe Sin Kyaw, Anthony G. Marson, Ailsa McLellan, Seth Mensah, Francis O'Neill, Jane Sargison, Sanjay M. Sisodiya, Jill Swan, Joanna M. Zakrewska, Munir Pirmohamed   +24 more
wiley   +1 more source

Sample Rejection Rate, Reasons for Rejection and Associated Factors Among Clinical Specimens Requested for Diagnostic Testing at Debre Tabor Comprehensive Specialized Hospital, South Gondar Zone, North West Ethiopia, 2025: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background and Aims Clinical specimen rejection is a significant issue in laboratory medicine, particularly in resource‐limited settings such as Ethiopia. Understanding the underlying reasons for specimen rejection is crucial for implementing effective strategies to minimize errors, enhance laboratory performance, and improve patient care. The
Mahider Shimelis Feyisa, Ayenew Berhan, Mekides Andargie Ferede, Alemie Fentie, Andargachew Almaw, Ayenew Assefa, Dessie Tegegne, Birhanemaskal Malkamu, Birhanu Getie, Shewaneh Damtie, Getu Abeje, Teklehaimanot Kiros, Rahel Birhanu Arage, Besfat Berihun Erega, Habtam Desse Alemayehu, Ermias Bekele Enyew, Bruktawit Eshetu, Mulat Erkihun   +17 more
wiley   +1 more source

تقييم رضا الأطباء و المرضى عن تطبيق المواصفة ISO 15189 في مختبرات ميديكير الطبية الفلسطينية الخاصة.

, 2023
Recently, all medical laboratories have become interested in ISO 15189, the first quality management ISO system for medical laboratories. To enhance and deliver high-quality healthcare services, it is important to understand patients’ and Physicians ...
Dina Mrwan Mohammad Abu Zayyad, دينا مروان محمد ابو زياد   +1 more
core  

Validation of an In-House-Developed GC-MS Method for 5α-Cholestanol According to ISO 15189:2012 Requirements.

, 2022
Objective: The aim of this study was to validate a gas chromatography-mass spectrometry (GC-MS) method for the measurement of 5 alpha-cholestanol in the clinical laboratory in agreement with ISO 15189 ...
Coker, Canan, Uysal, SEZER
core   +1 more source