Results 41 to 50 of about 3,891,643 (183)

Clinical requirements for extracellular vesicle assays

Journal of Extracellular Vesicles, 2019
The scientific and clinical interest in extracellular vesicles (EV) has grown exponentially during the past 15 years. As most research indicates that EVs can be utilised in diagnostics, prognostics and therapeutics, we may be on the brink of establishing
Lisa Ayers, Ryan Pink, David Raul Francisco Carter, Rienk Nieuwland   +3 more
doaj   +1 more source

LABORATORY DIAGNOSTICS OF CURRENT INFECTIOUS DISEASES ACCORDING TO INTERNATIONAL STANDARDS

Archives of Veterinary Medicine, 2010
One of the greatest challenges of modern laboratory diagnostic is selection of methods and procedures for fast and reliable diagnostic. Contemporary laboratory diagnostic is faced with the request to develop the technologies for rapid detection of agents
Sava Lazić, Tamaš Petrović, Maja Velhner, Dubravka Milanov, Sara Savić, Branka Vidić   +5 more
doaj   +1 more source

Influence of Intravenous Norepinephrine Administration on Melatonin Plasma Concentration in Awake and Anaesthetised Healthy Adult Volunteers

Journal of Pineal Research, Volume 78, Issue 6, November 2026.
ABSTRACT Melatonin (MEL) is an endogenous hormone that regulates circadian rhythm, immune function and oxidative stress responses. Norepinephrine (NE), an endogenous catecholamine, increases blood pressure through the sympathetic nervous system and is commonly administered intraoperatively or in the clinically ill patient for hemodynamic support ...
Marko MIrza Sahinovic, Ilonka Nadia de Keijzer, Manon Stern, Karin Marianne Vermeulen, Michel Maria Roger Fernand Struys, Anthony Ray Absalom, Johannes Pieter van den Berg, Jaap Jan Vos   +7 more
wiley   +1 more source

The Impact of Upfront DihydroPyrimidine Dehydrogenase (DPD) Testing on the Therapeutic Management of Patients Scheduled for 5‐FU

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Purpose 5‐fluorouracil (5‐FU) is catabolized by dihydropyrimidine dehydrogenase (DPD). DPD deficiency can trigger life‐threatening toxicities, and pretesting DPD is increasingly recommended. Here, we investigated the impact of upfront DPD testing on treatment strategy, that is, whether DPD status influences physicians' choice to use 5‐FU or ...
Govind Kallee, Sébastien Salas, Gérard Milano, Florence Duffaud, Laetitia Dahan, Joseph Ciccolini   +5 more
wiley   +1 more source

Method validation of a set of 12 GEM® Premier™ 4000 blood gas analyzers for point-of-care testing in a university teaching hospital

Practical Laboratory Medicine, 2018
Background: Blood gas analyzers are often integrated into point-of-care testing provisions. International standards (ISO 22870 and 15189) as adapted to French COFRAC regulations make accreditation of point-of-care testing obligatory.
Charlotte Oris, Yoan Clavel, Matthieu Jabaudon, Annick Pialat, Hadj Abdelkader Mohamed, Frédérique Lioret, Vincent Sapin, Damien Bouvier   +7 more
doaj   +1 more source

Transcranial Magnetic Stimulation as a Translational Biomarker in Early‐Phase Anti‐Seizure Medication Development: A Randomized, Double‐Blind, Placebo‐Controlled Study in Generalized Epilepsy

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 673-683, September 2026.
One‐third of epilepsy patients remain treatment‐resistant, underscoring the need for novel anti‐seizure medications (ASMs) and reliable biomarkers of central target engagement. Cortical hyperexcitability is a hallmark of epilepsy, making excitability a valuable pharmacodynamic biomarker for early‐phase drug development supporting go/no‐go decision ...
Catherine M. E. de Cuba, Titia Q. Ruijs, Annika A. de Goede, Robert J. Doll, Maria Juachon, Michel J. A. M. van Putten, Geert Jan Groeneveld, Jules A. A. C. Heuberger   +7 more
wiley   +1 more source

Investigating the suitability of ISO 15189:2007 for medical research [PDF]

, 2013
M.Tech. (Operations Management)Accreditation allows people to make an informed decision when selecting a laboratory. It demonstrates competence, impartiality and capability.
Cohen, Sarah Shoshana
core  

Clinical Utility of Trio Exome Sequencing in Rwandan Children With Autism Spectrum Disorder

Molecular Genetics &Genomic Medicine, Volume 14, Issue 9, September 2026.
Addressing the Gap: First trio‐based WES study of ASD in Rwanda, addressing African underrepresentation in global genomics. Diagnostic Yield: 12.9% yield of clinically relevant variants, consistent with global benchmarks (10%–30%). Genetic Findings: Confirmed de novo likely pathogenic variants identified in high‐impact ASD genes, including SYNGAP1 and ...
Olivier Hakizimana, Janvier Hitayezu, Jeanne P. Uyisenga, Norbert Dukuze, Marie Viviane Akimana, Laurence Mizero, Claudine Bampire, Charles Mudenge, Xavier Kanyambari Butoto, Laura Helou, Benoit Charloteaux, Jean‐Hubert Caberg, Vinciane Dideberg, Leonor Palmeira, Abdullateef Isiaka Alagbonsi, Vincent Bours, Annette Uwineza   +16 more
wiley   +1 more source

Validation and verification of examination procedures in medical laboratories: opinion of the EFLM Working Group Accreditation and ISO/CEN standards (WG-A/ISO) on dealing with ISO 15189:2012 demands for method verification and validation [PDF]

Clinical Chemistry and Laboratory Medicine (CCLM), 2019
Abstract This paper reflects the opinion of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Working Group Accreditation and ISO/CEN standards (WG-A/ISO). It aims to provide guidance for drawing up local/national documents about validation and verification of laboratory methods.
Roelofsen-de Beer, Roseri, Wielders, Jos, Boursier, Guilaine, Vodnik, Tatjana, Vanstapel, Florent, Huisman, Willem, Vukasović, Ines, Vaubourdolle, Michel, Sönmez, Çiğdem, Linko, Solveig, Brugnoni, Duilio, Kroupis, Christos, Lohmander, Maria, Šprongl, Luděk, Bernabeu- Andreu, Francisco, Meško Brguljan, Pika, Thelen, Marc   +17 more
openaire   +8 more sources

Accreditation of medical laboratories: System, process, benefits for labs [PDF]

Journal of Medical Biochemistry, 2017
One and key of the priorities in laboratory medicine is improvement of quality management system for patient safety. Quality in the health care is tightly connected to the level of excellence of the health care provided in relation to the current level ...
Zima Tomáš
doaj