Results 71 to 80 of about 57,189 (285)
Physiological Reports, 2020 The liver regenerates NADPH via multiple pathways to maintain redox balance and reductive biosynthesis. The pentose phosphate pathway (PPP) contributes to hepatic lipogenesis by supplying NADPH, and it is thought to play a major role in response to ...
Eunsook S. Jin +2 more
doaj +1 more source
USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis
Advanced Science, EarlyView.This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui +5 more
wiley +1 more source
Isocitrate dehydrogenases in physiology and cancer: biochemical and molecular insight
Cell & Bioscience, 2017 Isocitrate dehydrogenases play important roles in cellular metabolism and cancer. This review will discuss how the roles of isoforms 1 and 2 in normal cell and cancer metabolism are distinct from those of isoform 3. It will also explain why, unlike 1 and
Hamoud Al-Khallaf
doaj +1 more source
Effects of Medium Components on Isocitric Acid Production by Yarrowia lipolytica Yeast
Fermentation, 2020 The microbiological production of isocitric acid (ICA) is more preferable for its application in medicine and food, because the resulting product contains only the natural isomer—threo-DS.
Svetlana V. Kamzolova +3 more
doaj +1 more source
Isocitrate lyore-2 from N. crassa [PDF]
, 1973 Isocitrate lyase-2 from N ...
A. Rougemont +3 more
core +1 more source
Advanced Science, EarlyView.EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li +9 more
wiley +1 more source
Advanced Science, EarlyView.Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu +20 more
wiley +1 more source
On the heterogeneity of the mitochondrial C27-steroid 26-hydroxylase system
Journal of Lipid Research, 1976 Mitochondrial 26-hydroxylation of exogenous cholesterol, endogenous cholesterol, and 5β-cholestane-3α,7α,12α-triol was studied. 26-Hydroxylation of endogenous cholesterol was measured by mass fragmentography.
J Gustafsson
doaj +1 more source
CLINICAL STUDIES ON ISOCITRIC DEHYDROGENASE
Nihon Naika Gakkai Zasshi, 1963 イソクエン酸脱水素酵素(ICD)はTPNを補酵素とする脱水素酵素であり肝細胞中の糸粒体に主として認められているが,著者は正常者および各種疾患々者血清中の本酵素活性値を測定した.またこれと並行してトランスアミナーゼ活性値,乳酸脱水素酵素活性値を測定し,各酵素の変動および相関につき觀察した.イソクエン酸脱水素酵素は他の酵素に比べ,肝疾患に特異的であり,特に急性肝炎黄疸前期に著明な活性値上昇を来たし,また肝性昏睡時に中等度の活性値の上昇を来たすことを認めた.慢性肝炎,肝硬変では正常乃至は正常値を多少上廻る活性値を示したが,閉塞性黄疸では一般に上昇は認められず,二次的に肝細胞障害を来たした例には活性値上昇が認められた.その他の疾患ではICD値は正常値を示した ...
openaire +3 more sources
, 2022 The human isocitrate dehydrogenase (IDH) gene encodes for the isoenzymes IDH1, 2, and 3, which catalyze the conversion of isocitrate and α-ketoglutarate (α-KG) and are required for normal mammalian metabolism. Isocitrate dehydrogenase 1 and 2
Junxiong Chen +7 more
core +1 more source