Results 51 to 60 of about 57,189 (285)
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Purification of yeast isocitrate dehydrogenase [PDF]
Biochemical Journal, 1972 The NAD-linked isocitrate dehydrogenase from baker's yeast was purified to homogeneity (as judged by gel filtration and polyacrylamide-gel electrophoresis) with an overall yield of 50% by using dilute solutions of the allosteric effector (AMP) to elute the enzyme specifically from CM-cellulose.
openaire +2 more sources
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang +7 more
wiley +1 more source
Biocatalytic Isocitrate Production from Low‐Concentration Gaseous CO2 and Biobased 2‐Oxogultarate
Advanced Energy & Sustainability ResearchIsocitrate dehydrogenase (IDH) from yeast (EC 1.1.1.42) is an enzyme that catalyzes the decarboxylating isocitrate into 2‐oxogurtarate and carbon dioxide and the reverse process of the introducing carbon dioxide as a carboxy‐group to 2‐oxogurtarate to ...
Masamichi Hino, Yutaka Amao
doaj +1 more source
Scientific Reports, 2017 Recent data indicate that the metabolism of Mycobacterium tuberculosis (Mtb) inside its host cell is heavily dependent on cholesterol and fatty acids. Mtb exhibits a unique capacity to co-metabolize different carbon sources and the products from these ...
Wonsik Lee +3 more
doaj +1 more source
Effects of Nitrogen Deficiency on the Metabolism of Organic Acids and Amino Acids in Oryza sativa
Plants, 2022 Organic acids metabolism and nitrogen (N) metabolism in rice seedlings and the relationship between them are not fully understood. In this study, rice (Oryza sativa L. ssp. Indica) variety “Huanghuazhan” was used as the experimental material, and three N
Ling-Hua Chen +4 more
doaj +1 more source
Advanced Materials for Biologics Delivery to Brain Tumors
Advanced Materials, EarlyView.Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng +4 more
wiley +1 more source
浙江大学学报. 农业与生命科学版, 2003 The four enzymes of acetate kinase (AK), phosphotransacetylase (PTA), isocitrate lyase (ICL) and malate systhase (MS) which are involved in the acetate metabolism of Corynebacterium glutamicum have been developed in their assay methods.
RUAN Hong, XUAN Ri-rong
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Advanced Science, EarlyView.Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding +7 more
wiley +1 more source