Results 41 to 50 of about 57,189 (285)

Glioblastoma with extracranial parotid, lymph node, and pulmonary metastases: a case report

Radiology Case Reports, 2019
We present a rare case of an isocitrate dehydrogenase-wildtype glioblastoma with histologically proven parotid, cervical lymph node, and lung metastases.
Jeroen Swinnen, MD, Geert Gelin, MD, Sabine Fransis, MD, Jan Vandevenne, MD, PhD, Sofie Van Cauter, MD, PhD   +4 more
doaj   +1 more source

Nondecarboxylating and Decarboxylating Isocitrate Dehydrogenases: Oxalosuccinate Reductase as an Ancestral Form of Isocitrate Dehydrogenase [PDF]

Journal of Bacteriology, 2008
ABSTRACTIsocitrate dehydrogenase (ICDH) fromHydrogenobacter thermophiluscatalyzes the reduction of oxalosuccinate, which corresponds to the second step of the reductive carboxylation of 2-oxoglutarate in the reductive tricarboxylic acid cycle. In this study, the oxidation reaction catalyzed byH. thermophilusICDH was kinetically analyzed. As a result, a
Miho, Aoshima, Yasuo, Igarashi
openaire   +2 more sources

Evaluating Mechanisms of IDH1 Regulation through Site-Specific Acetylation Mimics

Biomolecules, 2021
Isocitrate dehydrogenase (IDH1) catalyzes the reversible NADP+-dependent oxidation of isocitrate to α-ketoglutarate (αKG). IDH1 mutations, primarily R132H, drive > 80% of low-grade gliomas and secondary glioblastomas and facilitate the NADPH-dependent ...
Joi Weeks, Alexandra I. Strom, Vinnie Widjaja, Sati Alexander, Dahra K. Pucher, Christal D. Sohl   +5 more
doaj   +1 more source

The regulatory properties of isocitrate dehydrogenase kinase and isocitrate dehydrogenase phosphatase from Escherichia coli ML308 and the roles of these activities in the control of isocitrate dehydrogenase

, 1984
1. Isocitrate dehydrogenase kinase can use ATP but not other nucleoside triphosphates as a phosphate donor. It responds hyperbolically to both ATP and isocitrate dehydrogenase. 2.
Nimmo, Gillian A., Nimmo, Hugh G.
core   +1 more source

Isocitrate dehydrogenase from Streptococcus mutans: biochemical properties and evaluation of a putative phosphorylation site at Ser102. [PDF]

PLoS ONE, 2013
Isocitrate deyhdrogenase (IDH) is a reversible enzyme in the tricarboxylic acid cycle that catalyzes the NAD(P)(+)-dependent oxidative decarboxylation of isocitrate to α-ketoglutarate (αKG) and the NAD(P)H/CO2-dependent reductive carboxylation of αKG to ...
Peng Wang, Ping Song, Mingming Jin, Guoping Zhu   +3 more
doaj   +1 more source

Integrated Bioinformatics-Based Subtractive Genomics Approach to Decipher the Therapeutic Drug Target and Its Possible Intervention against Brucellosis

Bioengineering, 2022
Brucella suis, one of the causative agents of brucellosis, is Gram-negative intracellular bacteria that may be found all over the globe and it is a significant facultative zoonotic pathogen found in livestock.
Kanwal Khan, Munirah Sulaiman Othman Alhar, Muhammad Naseer Abbas, Syed Qamar Abbas, Mohsin Kazi, Saeed Ahmad Khan, Abdul Sadiq, Syed Shams ul Hassan, Simona Bungau, Khurshid Jalal   +9 more
doaj   +1 more source

Detection of Isocitrate Lyase in Achlya flagellata [PDF]

, 1974
The colorimetric procedure of McFadden and Howes (1960) and the enzyme assay for isocitrate lyase (Shiio, Shiio, and McFadden, 1965) gave positive results for the presence of isocitrate lyase in Achlya flagellata oogonial cultures.
Ellzey, Joanne Tontz, Chavez, Christina D.   +1 more
core   +1 more source

Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2

Nature Communications, 2019
Isocitrate lyase (ICL) isoforms 1 and 2 are enzymes in the glyoxylate and methylcitrate cycles that enable Mycobacterium tuberculosis (Mtb) to use lipids as a carbon source.
Ram Prasad Bhusal, Wanting Jiao, Brooke X. C. Kwai, Jóhannes Reynisson, Annabelle J. Collins, Jonathan Sperry, Ghader Bashiri, Ivanhoe K. H. Leung   +7 more
doaj   +1 more source

Heterogeneous multimeric structure of isocitrate lyase in complex with succinate and itaconate provides novel insights into its inhibitory mechanism.

PLoS ONE, 2021
During the glyoxylate cycle, isocitrate lyases (ICLs) catalyze the lysis of isocitrate to glyoxylate and succinate. Itaconate has been reported to inhibit an ICL from Mycobacterium tuberculosis (tbICL).
Sunghark Kwon, Hye Lin Chun, Hyun Ji Ha, So Yeon Lee, Hyun Ho Park   +4 more
doaj   +1 more source

Multistep Enzymatic Low-density Polyethylene Degradation via Phenylalanine Monooxygenase and Isocitrate Lyase in Pseudomonas aeruginosa [PDF]

Plastics have become indispensable in modern industries; however, their resistance to natural degradation poses environmental challenges. Biological degradation technologies employing microorganisms offer promising solutions.
Donggeun, Choi, Sukkyoo, Lee, Hong Rae, Kim, Dong-Eun, Suh, Ye Eun, Lee   +4 more
core   +1 more source