Results 21 to 30 of about 57,189 (285)

Knocking out central metabolism genes to identify new targets and alternating substrates to improve lipid synthesis in Y. lipolytica

open access: yesFrontiers in Bioengineering and Biotechnology, 2023
Introduction: Systematic gene knockout studies may offer us novel insights on cell metabolism and physiology. Specifically, the lipid accumulation mechanism at the molecular or cellular level is yet to be determined in the oleaginous yeast Y.
Jiang Zhu   +9 more
doaj   +1 more source

Isocitrate Dehydrogenase Genes [PDF]

open access: yesDeutsches Ärzteblatt international, 2015
The molecular classification and taxonomy of malignant diseases, such as the one successfully applied and published by The Cancer Genome Atlas Project TCGA (http://cancergenome.nih.gov/) for urinary bladder and colorectal cancer, adenocarcinoma of the stomach, and glioblastoma multiforme, provides the opportunity to define so-called driver mutations ...
openaire   +2 more sources

Reductive TCA cycle catalyzed by wild-type IDH2 promotes acute myeloid leukemia and is a metabolic vulnerability for potential targeted therapy

open access: yesJournal of Hematology & Oncology, 2022
Background Isocitrate dehydrogenase-2 (IDH2) is a mitochondrial enzyme that catalyzes the metabolic conversion between isocitrate and alpha-ketoglutarate (α-KG) in the TCA cycle.
Peiting Zeng   +9 more
doaj   +1 more source

IDH1(R132H) Immunoexpression in Glioma

open access: yesAdvanced Medical Journal, 2023
Background and objectives: Gliomas are the most common type of primary brain tumors. They result from accumu-- lation of multiple genetic alterations. Isocitrate dehydrogenase 1 mutations are detected in gliomas.
Nyan Saeed Omer   +2 more
doaj   +1 more source

Stochastic Microsensors Based on Carbon Nanotubes for Molecular Recognition of the Isocitrate Dehydrogenases 1 and 2

open access: yesNanomaterials, 2022
Two three-dimensional (3D) stochastic microsensors based on immobilization of protoporphyrin IX (PIX) in single-walled carbon nanotubes (SWCNT) and multi-walled carbon nanotubes (MWCNT) decorated with copper (Cu) and gold (Au) nanoparticles were designed
Raluca-Ioana Stefan-van Staden   +3 more
doaj   +1 more source

Expression of IDH1, ATRX, p53 in Diagnosis of Gliomas as Per 2016 WHO Classification [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2023
Introduction: The 2016 World Health Organisation (WHO) classification of tumours of the Central Nervous System (WHO CNS 2016 classification) is used to classify diffuse gliomas as astrocytoma, Oligodendroglioma (ODG), glioblastoma which are three ...
Lokesh Kumar   +3 more
doaj   +1 more source

Serum isocitrate dehydrogenase activity in Reye's syndrome [PDF]

open access: yes, 1987
Serum levels of isocitrate dehydrogenase was determined in 12 Reye's syndrome patients and the enzyme levels were compared with serum ornithine carbamyl phosphate, glutamic oxaloacetic transaminase (aspartate aminotransferase), ammonia, and the stages of
Deshmukh, Devendra R.   +2 more
core   +1 more source

Isocitrate Lyase in Green Leaves [PDF]

open access: yesPlant Physiology, 1973
Isocitrate lyase (EC 4.1.3.1) has been demonstrated in crude dialyzed extracts of healthy spinach (Spinacia oleracea) leaves from commercial sources and wheat (Triticum aestivum) and maize (Zea mays) leaves stored in darkness in the cold room for 1 week.
H R, Godavari, S S, Badour, E R, Waygood
openaire   +2 more sources

Studying the Phosphorylation of Isocitrate Dehydrogenase in Humans [PDF]

open access: yes, 2023
Isocitrate dehydrogenase is an important enzyme in the citric acid cycle where it catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate.
Smith, Hannah
core   +4 more sources

Phase Ib study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis

open access: yesHepatology, EarlyView., 2022
Phase 1b study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Abstract Background and Aims We evaluated the efficacy and safety of the antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 inhibitor in pretreated advanced biliary tract cancers (BTCs ...
Jun Zhou   +13 more
wiley   +1 more source

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