Results 11 to 20 of about 57,189 (285)
Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP+-dependent isocitrate dehydrogenase (IDH). [PDF]
PLoS Genetics, 2017 DJ-1 is one of the causative genes for early onset familiar Parkinson's disease (PD) and is also considered to influence the pathogenesis of sporadic PD. DJ-1 has various physiological functions which converge on controlling intracellular reactive oxygen
Jinsung Yang +11 more
doaj +3 more sources
The role of isocitrate in control of the phosphorylation of isocitrate dehydrogenase in Escherichia coli ML308 [PDF]
FEBS Letters, 1985 Isocitrate dehydrogenase from Escherichia coli is regulated by a reversible phosphorylation mechanism. We confirm here that this permits intracellular isocitrate to rise to a level that can sustain growth on acetate. Isocitrate inhibits isocitrate dehydrogenase kinase and activates isocitrate dehydrogenase phosphatase in vitro.
El-Mansi, E.M.T. +2 more
openaire +3 more sources
Cloning and expression of isocitrate lyase from human round worm Strongyloides stercoralis
Parasite, 2000 A full length cDNA (1463 bp) encoding isocitrate lyase (EC 4.1.3.1) of Strongyloides stercoralis is described. The nucleotide sequence of this insert identified a cDNA coding for the isocitrate lyase.
Siddiqui A.A., Stanley C.S., Berk S.L.
doaj +2 more sources
Studies of Isocitrate Dehydrogenase From Bacillus caldotenax [PDF]
, 1992 Most micro-organisms contain an NADP-dependent isocitrate dehydrogenase (ICDH) activity. During growth of micro-organisms on acetate as the sole carbon source the two enzymes of the glyoxylate bypass, isocitrate lyase (ICL) and malate synthase (MS), are ...
Wild, Catherine Margaret
core +7 more sources
Scientific Reports, 2021 A unicellular cyanobacterium Synechocystis sp. PCC 6803 possesses a unique tricarboxylic acid (TCA) cycle, wherein the intracellular citrate levels are approximately 1.5–10 times higher than the levels of other TCA cycle metabolite.
Maki Nishii +3 more
doaj +1 more source
Physiological regulation of isocitrate dehydrogenase and the role of 2-oxoglutarate in Prochlorococcus sp. strain PCC 9511. [PDF]
PLoS ONE, 2014 The enzyme isocitrate dehydrogenase (ICDH; EC 1.1.1.42) catalyzes the oxidative decarboxylation of isocitrate, to produce 2-oxoglutarate. The incompleteness of the tricarboxylic acids cycle in marine cyanobacteria confers a special importance to ...
María Agustina Domínguez-Martín +5 more
doaj +1 more source
Structure and Function of Isocitrate Dehydrogenase From Escherichia coli ML308 [PDF]
, 1989 The level of activity of the NADP-dependent isocitrate dehydrogenase (ICDH) of E. coli ML308 is controlled by a reversible phosphorylation mechanism during growth on acetate as sole carbon source.
McKee, Jillian Stewart
core +6 more sources
Scientific Reports, 2021 Recent evidence suggests that cellular perturbations play an important role in the pathogenesis of cardiovascular diseases. Therefore, we analyzed the association between the levels of urinary metabolites and arterial stiffness. Our cross-sectional study
Ji-Hee Haam +8 more
doaj +1 more source
Frontiers in Microbiology, 2019 Glycerol is an important by-product of the biodiesel industry and its transformation into value-added products like keto acids is being actively pursued in order to improve the efficacy of this renewable energy sector.
Azhar A. Alhasawi +7 more
doaj +1 more source
2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations. [PDF]
PLoS ONE, 2011 Gliomas frequently contain mutations in the cytoplasmic NADP(+)-dependent isocitrate dehydrogenase (IDH1) or the mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDH2). Several different amino acid substitutions recur at either IDH1 R132 or IDH2
Genglin Jin +7 more
doaj +1 more source