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Citrate and isocitrate in plant metabolism [PDF]
Biochimica Et Biophysica Acta - Bioenergetics, 1998 The relevance of citrate and isocitrate metabolism in plants is discussed in connection with the different pathways for their conversions. The routes for citrate and isocitrate conversions are incorporated into the system of cross-linked metabolic processes and may provide carbon skeletons for nitrogen assimilation and reducing equivalents for ...
Pinheiro de Carvalho M A A +2 more
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Isocitrate dehydrogenase 1 Gene Mutation Is Associated with Prognosis in Clinical Low-Grade Gliomas. [PDF]
PLoS ONE, 2015 Isocitrate dehydrogenase 1 gene mutations are found in most World Health Organization grade II and III gliomas and secondary glioblastomas. Isocitrate dehydrogenase 1 mutations are known to have prognostic value in high-grade gliomas.
Ming-Yang Li +8 more
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Frontiers in Endocrinology, 2020 Aim: Isocitrate dehydrogenase 1 (IDH1) is key enzyme involved in cellular metabolism and DNA repair. Mutations in IDH1 occur in up to 25% of cholangiocarcinomas.
Li Su +5 more
exaly +3 more sources
Radiomics-based models to predict IDH mutation status and prognosis in gliomas using MRI: a multicenter study [PDF]
Frontiers in OncologyIntroductionGliomas are infiltrative primary intracranial tumors with marked biological and clinical heterogeneity. Prognosis varies widely and depends on tumor grade, histopathological characteristics, and molecular alterations. Isocitrate dehydrogenase
Esra Sümer-Arpak +12 more
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Structural basis of allosteric activation of Mycobacterium tuberculosis isocitrate lyase 2 [PDF]
Communications BiologyMycobacterium tuberculosis isocitrate lyase 2 (ICL2) is an allosterically regulated enzyme required for growth on non-glycolytic carbon substrates during infection.
Evelyn Yu-Wen Huang +8 more
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Indian Journal of Neurosurgery, 2023 Introduction In consonance with current the World Health Organization (WHO) classification of the central nervous system (CNS) tumors (2016), histological diagnosis of gliomas should be reinforced by molecular information.
Santosh Sharma +5 more
doaj +1 more source
Advances in Immune Microenvironment and Immunotherapy of Isocitrate Dehydrogenase Mutated Glioma
Frontiers in Immunology, 2022 The tumor immune microenvironment and immunotherapy have become current important tumor research concerns. The unique immune microenvironment plays a crucial role in the malignant progression of isocitrate dehydrogenase (IDH) mutant gliomas.
Dongming Yan +4 more
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The relative isoform expression levels of isocitrate dehydrogenase in breast cancer: IDH2 is a potential target in MDA-MB-231 cells [PDF]
Korean Journal of Clinical Oncology, 2023 Purpose The isocitrate dehydrogenase (IDH) family plays an essential role in metabolism and energy production. The relative expression levels of IDH isoforms (IDH1, IDH2, and IDH3) have prognostic significance in several malignancies, including breast ...
Shuyu Piao +7 more
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Technology in Cancer Research & Treatment, 2022 Background and Purpose: To quantitatively compare the recurrence patterns of glioblastoma (isocitrate dehydrogenase-wild type) versus grade 4 isocitrate dehydrogenase-mutant astrocytoma (wild type isocitrate dehydrogenase and mutant isocitrate ...
James Stewart PhD +18 more
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Animal, 2022 The enzyme isocitrate dehydrogenase (EC 1.1.1.42; 1; NADP+ dependent) located in the mammary cell cytosol mediates the synthesis of the majority of reducing equivalents for the energetically demanding milk fat and cholesterol synthesis in mammary cell ...
T. Larsen +3 more
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