Results 31 to 40 of about 57,189 (285)

The isocitrate dehydrogenase from cyanobacteria

, 2022
S.73-79The present communication describes the properties of isocitrate dehydrogenase in crude extracts from the unicellular Anacystis nidulans and from heterocysts and vegetative cells of Nostoc muscorum and Anabaena cylindrica.
Refaian, M., Neuer, G., Papen, H., Bothe, H.   +3 more
core   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Immunohistochemistry as a tool for identifying PDGFRA amplification in central nervous system tumors. [PDF]

Brain Pathol
PDGFRA gene amplification is now recognized as a diagnostically and prognostically relevant molecular alteration in central nervous system tumors. Herein, we demonstrated that PDGFRA immunohistochemistry is a highly specific and sensitive biomarker for identifying PDGFRA amplification and should be part of the neuropathologist's routine panel of ...
Tauziède-Espariat A, Amargos G, Sassi F, Hasty L, Métais A, Varlet P.   +5 more
europepmc   +2 more sources

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Single arginine mutation in two yeast isocitrate dehydrogenases: biochemical characterization and functional implication. [PDF]

PLoS ONE, 2014
Isocitrate dehydrogenase (IDH), a housekeeping gene, has drawn the attention of cancer experts. Mutation of the catalytic Arg132 residue of human IDH1 (HcIDH) eliminates the enzyme's wild-type isocitrate oxidation activity, but confer the mutant an ...
Ping Song, Huanhuan Wei, Zhengyu Cao, Peng Wang, Guoping Zhu   +4 more
doaj   +1 more source

Phosphorylation Inactivates Escherichia coli Isocitrate Dehydrogenase by Preventing Isocitrate Binding

Journal of Biological Chemistry, 1989
Equilibrium binding studies demonstrate that purified Escherichia coli isocitrate dehydrogenase binds isocitrate, alpha-ketoglutarate, NADP, and NADPH at 1:1 ratios of substrate to enzyme monomer. The phosphorylated enzyme, which is completely inactive, is unable to bind isocitrate but retains the ability to bind NADP and NADPH.
A M, Dean, M H, Lee, D E, Koshland
openaire   +2 more sources

Isocitrate dehydrogenase mutations in gliomas [PDF]

Neuro-Oncology, 2015
Over the last decade, extraordinary progress has been made in elucidating the underlying genetic causes of gliomas. In 2008, our understanding of glioma genetics was revolutionized when mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) were identified in the vast majority of progressive gliomas and secondary glioblastomas (GBMs).
Matthew S, Waitkus, Bill H, Diplas, Hai, Yan   +2 more
openaire   +2 more sources

Isocitrate dehydrogenase mutations in leukemia [PDF]

Journal of Clinical Investigation, 2013
Recent genome-wide discovery studies have identified a spectrum of mutations in different malignancies and have led to the elucidation of novel pathways that contribute to oncogenic transformation. The discovery of mutations in the genes encoding isocitrate dehydrogenase (IDH) has uncovered a critical role for altered metabolism in oncogenesis, and the
Anna Sophia, McKenney, Ross L, Levine
openaire   +2 more sources

Cytosolic NADP-isocitrate dehydrogenase in Arabidopsis leaves and roots

, 2012
NADP-dependent isocitrate dehydrogenase (NADP-ICDH) catalyses the production of NADPH, which is an essential component in the cellular homeostasis. In Arabidopsis, the kinetic parameters (K m and V max) of cytosolic NADP-ICDH were different in leaves and
F. J. Corpas, M. Leterrier, J. M. Palma, J. B. Barroso   +3 more
core   +1 more source

Single-Cell Discrimination of Citrate/Isocitrate Isomers via Induced Nano-Electrospray Ionization Tandem Mass Spectrometry

Zhipu Xuebao
Citrate (CA) and isocitrate (ICA) are key isomeric metabolites in the tricarboxylic acid (TCA) cycle, synthesized sequentially from acetyl-CoA and oxaloacetate, with isomerization catalyzed by aconitase 2 (ACO2). The dynamic balance between CA and ICA is
Chen LING, Zhuang-hao HOU, Guang-ming HUANG   +2 more
doaj   +1 more source