Results 21 to 30 of about 179,953 (145)
Structure of the Monomeric Isocitrate Dehydrogenase Evidence of a Protein Monomerization by a Domain Duplication [PDF]
, 2002 NADP+-dependent isocitrate dehydrogenase is a member of the β-decarboxylating dehydrogenase family and catalyzes the oxidative decarboxylation reaction from 2R,3S-isocitrate to yield 2-oxoglutarate and CO2 in the Krebs cycle.
Tanaka, Isao +5 more
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, 2009 The oleaginous yeast Lipomyces starkeyi can accumulate intracellular lipids to over 60% of its cell dry mass under a nitrogen-limited condition. We showed that extracellular and intracellular citrate concentrations of L.
Tang, Wei +5 more
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Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations [PDF]
, 2021 The most frequently mutated metabolic genes in human cancer are those encoding the enzymes isocitrate dehydrogenase 1 (IDH1) and IDH2; these mutations have so far been identified in more than 20 tumor types.
Hvinden, Ingvild Comfort +3 more
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Isocitrate Dehydrogenase Mutations in Glioma: Genetics, Biochemistry, and Clinical Indications
, 2020 Mutations in isocitrate dehydrogenase (IDH) are commonly observed in lower-grade glioma and secondary glioblastomas. IDH mutants confer a neomorphic enzyme activity that converts α-ketoglutarate to an oncometabolite D-2-hydroxyglutarate, which ...
Kareem A. Zaghloul +4 more
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Cytosolic NADP-isocitrate dehydrogenase in Arabidopsis leaves and roots
, 2012 NADP-dependent isocitrate dehydrogenase (NADP-ICDH) catalyses the production of NADPH, which is an essential component in the cellular homeostasis. In Arabidopsis, the kinetic parameters (K m and V max) of cytosolic NADP-ICDH were different in leaves and
F. J. Corpas +3 more
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Isocitrate dehydrogenase gene variants in cancer and their clinical significance [PDF]
, 2021 Human isocitrate dehydrogenase (IDH) genes encode for the IDH1, 2 & 3 isoenzymes which catalyse the formation of 2-oxoglutarate from isocitrate and are essential for normal mammalian metabolism.
Cadoux-Hudson, Thomas +2 more
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Research Progress of Isocitrate Dehydrogenase Gene Mutation Therapy
, 2023 Isocitrate dehydrogenase (IDH), a key enzyme in the tricarboxylic acid cycle, plays an important role in cellular energy metabolism. When the IDH gene is mutated, the enzyme activity is altered, resulting in an accumulation of a large amount of the tumor
HUANG Xiongfei +3 more
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, 1985 This article 'Genetic Control of Isocitrate Dehydrogenase (IDH) and Malate Dehydrogenase (MDH) Isozymes in Rice Brown Planthopper (BPH)' appeared in the International Rice Research Newsletter series, created by the International Rice Research Institute ...
Saxena, R. C., Mujer, C. V.
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, 2021 Isocitrate dehydrogenase (IDH) is a fundamental enzyme for carbon metabolism in the Krebs cycle. This enzyme is required for oxidation-reduction reactions in both eukaryotic and prokaryotic cells and plays a critical role in their growth and pathogenesis.
Sahabettin, Selek +3 more
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Expression of isocitrate dehydrogenase-1 in glioblastoma, Bangladesh perspective [PDF]
, 2023 Background: Glioblastoma is the most frequent malignant brain tumor in adults. Various studies have identified IDH (isocitrate dehydrogenase) mutation as a hallmark genetic alteration in glial tumors.
Mir, Ratim +5 more
core +1 more source