Results 41 to 50 of about 179,953 (145)

Complement receptor C3aR marks heterogeneous tumor‐associated macrophage states associated with improved survival in IDH‐wildtype glioblastoma

open access: yesBrain Pathology, EarlyView.
C3aR expression in IDH‐wildtype glioblastoma is predominantly associated with the myeloid/macrophage compartment and heterogeneous macrophage states. C3aR‐high tumors are enriched among MGMT promoter‐methylated tumors and show improved overall survival, although the prognostic association requires independent validation.
Marion Imara   +9 more
wiley   +1 more source

PTEN homozygous deletion is a negative prognostic factor in tumor treating fields‐treated glioblastoma, IDH wildtype patients

open access: yesBrain Pathology, EarlyView.
In a molecularly confirmed cohort of 64 newly diagnosed, TTFields‐treated glioblastomas, IDH‐wildtype, homozygous PTEN deletion was associated with markedly shorter overall survival (368 vs. 603 days) and remained an independent adverse prognostic factor.
Jakob Nückles   +15 more
wiley   +1 more source

Serum isocitrate dehydrogenase activity in Reye's syndrome [PDF]

open access: yes, 1987
Serum levels of isocitrate dehydrogenase was determined in 12 Reye's syndrome patients and the enzyme levels were compared with serum ornithine carbamyl phosphate, glutamic oxaloacetic transaminase (aspartate aminotransferase), ammonia, and the stages of
Deshmukh, Devendra R.   +2 more
core   +1 more source

Common pathways and outliers in glucose catabolism across Trypanosomatidae

open access: yesThe FEBS Journal, EarlyView.
Trypanosomatid parasites, including Trypanosoma sp., Leishmania sp., Phytomonas sp., and Vickermania sp., share a common motif: a metabolism built around the glycosome, a unique peroxisome‐derived organelle housing the first steps of glycolysis. Yet, these organisms have evolved remarkably diverse strategies to catabolize glucose, excreting distinct ...
Fred R. Opperdoes   +5 more
wiley   +1 more source

Cloning and characterization of the isocitrate dehydrogenase gene from oleaginous yeast Lipomyces starkeyi

open access: yes, 2008
Oleaginous yeast Lipomyces starkeyi can accumulate intracellular lipids over 65% of its cell dry weight [1]. Mitochondrial NAD+-specific isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrare to α-ketoglutarate in eukaryotic
唐伟, 赵宗保, 张素芳, 谭海东
core  

Epigenetic Regulation in the Pathogenesis of Periodontitis

open access: yesJournal of Periodontal Research, EarlyView.
The aim of this narrative literature review was to identify epigenetic marks associated with periodontitis and to place them in a biological context. The literature was reviewed based on pre‐defined criteria. Cell type specific chromatin and mRNA modifications were included.
Henrik Dommisch   +3 more
wiley   +1 more source

The regulatory properties of isocitrate dehydrogenase kinase and isocitrate dehydrogenase phosphatase from Escherichia coli ML308 and the roles of these activities in the control of isocitrate dehydrogenase

open access: yes, 1984
1. Isocitrate dehydrogenase kinase can use ATP but not other nucleoside triphosphates as a phosphate donor. It responds hyperbolically to both ATP and isocitrate dehydrogenase. 2.
Nimmo, Gillian A., Nimmo, Hugh G.
core   +1 more source

Patient‐derived surgical samples reveal the cellular and molecular signatures of glioblastoma infiltration in distinct radiological zones

open access: yesBrain Pathology, Volume 36, Issue 6, November 2026.
Integrated histological and transcriptional profiling of the glioblastoma periphery reveals clinically relevant tumor infiltration beyond MRI‐defined boundaries. MRI‐guided biopsies from contrast‐enhancing (CE), non‐contrast‐enhancing (nCE), edema (E), and radiologically normal (N) regions demonstrate that nCE areas frequently retain neoplastic and ...
Olaya de Dios   +18 more
wiley   +1 more source

Arabidopsis thaliana mRNA for isocitrate dehydrogenase gen bank AJ437268

open access: yes, 2002
LOCUS AJ437268 1610 bp mRNA linear PLN 15-APR-2005 DEFINITION Arabidopsis thaliana mRNA for isocitrate dehydrogenase. ACCESSION AJ437268 VERSION AJ437268.1 GI:19171468 KEYWORDS IDH gene; isocitrate dehydrogenase ...
De Bellis   +4 more
core  

MOESM1 of RNA editing-based classification of diffuse gliomas: predicting isocitrate dehydrogenase mutation and chromosome 1p/19q codeletion

open access: yes, 2019
Additional file 1: Figure S1. ROC plots for predicting isocitrate dehydrogenase (IDH) mutation and chromosome 1p/19q codeletion simultaneously. We trained SVM, RF, and AB with feature selection within each fold (10-fold cross validation) to classify ...
Emily Su (341331)   +3 more
core   +1 more source

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