Results 61 to 70 of about 179,953 (145)

Deepening the Understanding of Platelet‐Derived RNA as Biomarker for Glioblastoma Through GSEA, TDEA, and Elastic Net Regularization Analysis

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Glioblastoma (GBM) is the most aggressive form of primary brain cancer. Blood platelets have emerged as biomarkers where their RNA expression pattern indicates a tumor's presence. Our study aimed to characterize these patterns to identify biological processes associated with GBM and to evaluate their potential as a non‐invasive ...
Anna Giczewska, Krzysztof Pastuszak, Leon van Hout, Edward Post, Jip Ramaker, Ken Zwaan, Anna Supernat, Bart A. Westerman   +7 more
wiley   +1 more source

Location and type of isocitrate dehydrogenase mutations influence clinical characteristics and disease outcome of acute myeloid leukemia [PDF]

, 2013
Background: Mutations of isocitrate dehydrogenase 1 and 2 are novel common genetic alterations identified in acute myeloid leukemia. Aims: To investigate the frequency, clinical associations and prognostic effect of isocitrate dehydrogenase 1 and 2 ...
Dolgos, Janos, Karaszi, Eva, Bors, Andras, Fekete, Sandor, Feczko, Angela, Lehoczky, Eniko, Andrikovics, Hajnalka, Batai, Arpad, Adam, Emma, Meggyesi, Nóra, Lovas, Nora, Matrai, Zoltan, Tordai, Attila, Csomor, Judit, Koszarska, Magdalena, Kozma, Andras, Sipos, Andrea, Reichardt, Judit, Orbán, Tamás I., Masszi, Tamas   +19 more
core   +1 more source

Improved Method for Obtaining Patient‐Derived Glioblastoma Organoid and Primary Cells: A Generic and Simplified Approach for Intracranial Tumor With Minimized Input

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
An improved and simplified method enables the generation of primary tumor cells and tumoroids from the same tissue sample with minimal input, applicable universally to both intracranial and spinal tumors. Comparative analysis of drug screening results with patient follow‐up data allows for the assessment of individual drug sensitivity.
Siyuan Wang, Zhonggang Shi, Chihao Zhu, Dawei Dai, Xi Yang, Zhiyi Zhou, Qianying Qiu, Wenhua Sun, Yifeng Miao, Yongming Qiu   +9 more
wiley   +1 more source

METTL3 Increases Temozolomide Resistance in MGMT‐Negative Glioblastoma by Enhancing CBX5 mRNA Stability in an m6A‐IGF2BP2‐Dependent Manner

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
METTL3‐dependent m6A modification and IGF2BP2‐associated CBX5 mRNA stabilization help maintain CBX5 expression in MGMT‐negative glioblastoma. During temozolomide (TMZ) treatment, CBX5 contributes to ATM–RAD51‐associated signaling, limits persistent DNA damage and apoptosis, and thereby supports cell survival and TMZ resistance.
Hui Deng, Ruoyu Chen, Daohong Qu, Cifu Qu, Jia Shi   +4 more
wiley   +1 more source

Development of Novel Therapeutics Targeting Isocitrate Dehydrogenase Mutations in Cancer

, 2018
Isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that catalyze the conversion of isocitrate to α-ketoglutarate (αKG). IDH1 and IDH2 regulate several cellular processes, including oxidative respiration, glutamine metabolism ...
Horrick Sharma
core   +1 more source

Integrating Multimodal MRI Habitat and Transformer‐Based Pathomics to Predict High‐Risk Molecular Subtypes and Explore Biological Mechanisms in Adult Diffuse Gliomas

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Based on the 2021 WHO CNS5 guidelines, this study introduces an integrated high‐risk molecular classification for gliomas and constructs a predictive model by combining multimodal MRI habitat imaging, Transformer‐based WSI pathomics, and clinical information.
Wenju Niu, Xin Duan, Xuan Li, Zehui Li, Qian Liang, Xiangli Yang, Yan Tan, Xiaochun Wang, Guoqiang Yang, Hui Zhang   +9 more
wiley   +1 more source

Mitochondrial Metabolic Reprogramming in Glioma: Mechanisms of Tumorigenesis and Implications for Clinical Therapy

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
In gliomas, mitochondria integrate glucose, lipid, protein, and nucleotide metabolism to support proliferation, invasion, treatment resistance, and adaptation, with D‐2‐hydroxyglutarate‐driven remodeling in IDH‐mutant tumors and diverse metabolic states in IDH wild‐type glioblastomas.
Liangqi Jiang, Mingrui Li, Zhen Li, Qing Liu, Yang Li   +4 more
wiley   +1 more source

Measuring the plankton CO2 production throughout the water column by the isocitrate dehydrogenase (IDH) activity.

, 2016
Knowledge about Carbon flux in the ocean is limited by the complexity and expense of its measurement. Calculating it from plankton respiration provides an inexpensive alternative to sediment traps.
Martínez Sánchez, Ico, Packard, Theodore T., Tames Espinosa, Mayte, Gómez Cabrera, May   +3 more
core  

NADP+ -dependent isocitrate dehydrogenase activity in marine plankton

, 2018
NADP+-isocitrate dehydrogenase (NADP-IDH), as one of the most active intracellular CO2-producing enzymes, was measured in marine plankton by adapting an enzyme assay to the 0.7–50 μm, 50–200 μm, and 200–2000 μm size fraction of the Canary Islands coastal
Romero-Kutzner, Vanesa, Tames-Espinosa, Mayte, Packard, Theodore T., Martínez, Ico, Bondyale-Juez, Daniel R., Gómez, May   +5 more
core   +1 more source

Tumor Treating Fields Enhance Temozolomide‐Associated Growth Suppression in Glioblastoma Cells and Patient‐Derived Organoids Through Cell‐Cycle Blockade, Apoptosis, and SMAD‐Associated Signaling

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Tumor Treating Fields enhanced temozolomide‐associated growth suppression in glioblastoma cells and patient‐derived organoids. Combined treatment reduced viability and clonogenic growth, increased apoptosis‐associated responses, and was accompanied by G2/M‐phase accumulation and selected SMAD‐associated signaling changes.
Haiping Zhu, Yingbo Hou, Xuetao Li, Yi Tang, Zuoyu Jiang, Yang Zhang, Xuewen Zhang, Jiaming Du, Yang Zhu, Hanmiao Dong, Yeyang Xu, Ruoyu Sun, Chenyang Li, Zijian Han, Jian Lu, Lingzhi Xiong, Yulun Huang   +16 more
wiley   +1 more source