Results 81 to 90 of about 179,953 (145)

Mismatch repair protein mutations in isocitrate dehydrogenase (IDH)-mutant astrocytoma and IDH-wild-type glioblastoma. [PDF]

Neurooncol Adv, 2023
Richardson TE, Yokoda RT, Rashidipour O, Vij M, Snuderl M, Brem S, Hatanpaa KJ, McBrayer SK, Abdullah KG, Umphlett M, Walker JM, Tsankova NM.   +11 more
europepmc   +1 more source

Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle

, 2008
Here we describe two families with retinitis pigmentosa, a hereditary neurodegeneration of rod and cone photoreceptors in the retina. Affected family members were homozygous for loss-of-function mutations in IDH3B, encoding the Β-subunit of NAD-specific ...
Dryja, Thaddeus P., Colman, Roberta F., Berson, Eliot L., Hartong, Dyonne T., Dange, Mayura, McGee, Terri L.   +5 more
core   +1 more source

Gene expression changes of isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2 affect carcinogenesis and survival probability

Isocitrate dehydrogenase (IDH) is an essential metabolic enzyme in the regulation of cellular metabolism. IDH gene encodes three protein isoforms, IDH1, IDH2, and IDH3, and the expression level of isoforms is altered in human cancer types.
Atalay, Esra Bulut, BULUT ATALAY, ESRA
core   +1 more source

Impact of Frontline Ivosidenib on Volumetric Growth Patterns in Isocitrate Dehydrogenase-mutant Astrocytic and Oligodendroglial Tumors. [PDF]

Clin Cancer Res, 2023
Kamson DO, Puri S, Sang Y, Shi MJ, Blair L, Blakeley JO, Laterra J.   +6 more
europepmc   +1 more source

Dabrafenib Plus Trametinib: An Impressive Response in an Adult Patient With BRAF V600E-Mutated and Isocitrate Dehydrogenase (IDH) Wild-Type Glioma. [PDF]

Cureus, 2022
Costa IN, Reis J, Pinheiro J, Silva R, Fernandes C.   +4 more
europepmc   +1 more source

Association of Isocitrate Dehydrogenase (IDH) Status With Edema to Tumor Ratio and Its Correlation With Immune Infiltration in Glioblastoma. [PDF]

Front Immunol, 2021
Dubinski D, Won SY, Rauch M, Behmanesh B, Ngassam LDC, Baumgarten P, Senft C, Harter PN, Bernstock JD, Freiman TM, Seifert V, Gessler F.   +11 more
europepmc   +1 more source

Diagnostic Utility of Oncomine Comprehensive Assay v3 in Differentiating Between Isocitrate Dehydrogenase (IDH)-mutated Grade II-III Astrocytoma and Oligodendroglioma. [PDF]

In Vivo, 2021
Kim SW, Park BJ, Kim HS, Na K.
europepmc   +1 more source

Survival in patients with glioblastoma at a first progression does not correlate with isocitrate dehydrogenase (IDH)1 gene mutation status. [PDF]

Jpn J Clin Oncol, 2021
Tabei Y, Kobayashi K, Saito K, Shimizu S, Suzuki K, Sasaki N, Shiokawa Y, Nagane M.   +7 more
europepmc   +1 more source

Isocitrate dehydrogenase in Aedes aegypti: formal genetics, preliminary linkage data and study of natural populations.

, 1978
Two loci for isocitrate dehydrogenase (Idh-1 ad Idh-2) are described in Ae. aegypti, both polymorphic with two codominant alleles. Crosses made to test linkage relationships of Idh-1 indicate that this locus is independent from sex (chromosome 1) and ...
Bullini L., CIANCHI, Maria Rossella, CANCRINI, Gabriella, Tordi MP, Giangrande A   +4 more
core  

Targeting of Mutant Isocitrate Dehydrogenase in Glioma: A Systematic Review

Background/Objectives: Mutant isocitrate dehydrogenase (IDH) inhibitors represent a major advance in precision oncology. The recent Food and Drug Administration approval of vorasidenib for IDH-mutant glioma highlights its therapeutic potential in this ...
Tyler A. Lanman, L. Nicolas Gonzalez Castro   +1 more
core   +1 more source