Inhibitory Effects of Diketopiperazines from Marine-Derived Streptomyces puniceus on the Isocitrate Lyase of Candida albicans [PDF]
Molecules, 2019 The glyoxylate cycle is a sequence of anaplerotic reactions catalyzed by the key enzymes isocitrate lyase (ICL) and malate synthase, and plays an important role in the pathogenesis of microorganisms during infection.
Heegyu Kim +3 more
doaj +2 more sources
In Silico Screening of Isocitrate Lyase for Novel Anti-Buruli Ulcer Natural Products Originating from Africa [PDF]
Molecules, 2018 Buruli ulcer (BU) is caused by Mycobacterium ulcerans and is predominant in both tropical and subtropical regions. The neglected debilitating disease is characterized by chronic necrotizing skin lesions attributed to a mycolactone, which is a macrolide ...
Samuel K. Kwofie +9 more
doaj +2 more sources
Comparison of Biochemical Activities between High and Low Lipid-Producing Strains of Mucor circinelloides: An Explanation for the High Oleaginicity of Strain WJ11. [PDF]
PLoS ONE, 2015 The oleaginous fungus, Mucor circinelloides, is one of few fungi that produce high amounts of γ-linolenic acid (GLA); however, it usually only produces
Xin Tang +6 more
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RegA Plays a Key Role in Oxygen-Dependent Establishment of Persistence and in Isocitrate Lyase Activity, a Critical Determinant of In vivo Brucella suis Pathogenicity [PDF]
Frontiers in Cellular and Infection Microbiology, 2017 For aerobic human pathogens, adaptation to hypoxia is a critical factor for the establishment of persistent infections, as oxygen availability is low inside the host. The two-component system RegB/A of Brucella suis plays a central role in the control of
Elias Abdou +8 more
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Study on the differences in sugar-acid metabolism of Sweet Orange ‘Newhall’ with different rootstocks [PDF]
BMC Plant BiologyBackground Citrus rootstock selection plays a critical role in modulating sugar-acid metabolism, thereby influencing fruit flavor quality. This study systematically investigated the dynamic changes in sugar and acid components, key enzyme activities, and
Qingqing Ma +14 more
doaj +2 more sources
Demystifying the catalytic pathway of Mycobacterium tuberculosis isocitrate lyase. [PDF]
Sci Rep, 2020 Ibeji CU +5 more
europepmc +3 more sources
Stereochemical Course of the Isocitrate Lyase Reaction
Journal of Biological Chemistry, 1964 Milon Sprecher +2 more
openalex +4 more sources
Inhibition of Paracoccidioides lutzii Pb01 isocitrate lyase by the natural compound argentilactone and its semi-synthetic derivatives. [PDF]
PLoS ONE, 2014 The dimorphic fungus Paracoccidioides spp. is responsible for paracoccidioidomycosis, the most prevalent systemic mycosis in Latin America, causing serious public health problems.
Renata Silva do Prado +8 more
doaj +2 more sources
An isocitrate lyase gene-deleted strain of Nocardia seriolae in live attenuated vaccine development against fish nocardiosis [PDF]
Frontiers in Veterinary ScienceBackgroundFish nocardiosis caused by Nocardia seriolae is a severe bacterial disease in aquaculture, causing significant economic losses. The effectiveness of antibiotics in dealing with nocardiosis induced by N. seriolae is not satisfactory.
Guanying Lin +8 more
doaj +2 more sources
Modulation of Central Carbon Metabolism by Acetylation of Isocitrate Lyase in Mycobacterium tuberculosis. [PDF]
Sci Rep, 2017 Bi J +7 more
europepmc +3 more sources