Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2 [PDF]
Nature Communications, 2019 Isocitrate lyase (ICL) isoforms 1 and 2 are enzymes in the glyoxylate and methylcitrate cycles that enable Mycobacterium tuberculosis (Mtb) to use lipids as a carbon source.
Ram Prasad Bhusal +7 more
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Cloning and expression of isocitrate lyase from human round worm Strongyloides stercoralis
Parasite, 2000 A full length cDNA (1463 bp) encoding isocitrate lyase (EC 4.1.3.1) of Strongyloides stercoralis is described. The nucleotide sequence of this insert identified a cDNA coding for the isocitrate lyase.
Siddiqui A.A., Stanley C.S., Berk S.L.
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Discovery of a Novel Inhibitor Structure of Mycobacterium tuberculosis Isocitrate Lyase [PDF]
Molecules, 2022 Tuberculosis remains a global threat to public health, and dormant Mycobacterium tuberculosis leads to long-term medication that is harmful to the human body. M. tuberculosis isocitrate lyase (MtICL), which is absent in host cells, is a key rate-limiting
Changyuan Duan +6 more
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Physiological role of isocitrate lyase in dibenzo-p-dioxin and dibenzofuran metabolism by Sphingomonas wittichii RW1 [PDF]
Journal of Genetic Engineering and Biotechnology, 2022 Background Sphingomonas wittichii RW1 is one out of three strains capable of metabolizing dioxin as a sole source for carbon and energy. Under laboratory conditions the degradation rates for these aromatics are relatively high (5 and 8 h for dibenzofuran
Rayan M. Faisal, Aveen H. Rasol
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Structural basis of allosteric activation of Mycobacterium tuberculosis isocitrate lyase 2 [PDF]
Communications BiologyMycobacterium tuberculosis isocitrate lyase 2 (ICL2) is an allosterically regulated enzyme required for growth on non-glycolytic carbon substrates during infection.
Evelyn Yu-Wen Huang +8 more
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Isocitrate lyase plays important roles in plant salt tolerance [PDF]
BMC Plant Biology, 2019 Background Isocitrate lyase (ICL) is a key enzyme in the glyoxylate cycle. In a previous study in rice, the expression of the ICL-encoding gene (OsICL) was highly induced by salt stress and its expression was enhanced in transgenic rice lines ...
Worawat Yuenyong +3 more
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Pharmaceutical development of a medicinal product containing an isocitrate lyase inhibitor [PDF]
PharmaciaIsocitrate lyase (ICL), a key enzyme of the glyoxylate shunt in Mycobacterium tuberculosis, is considered a potential therapeutic target for drug-resistant and persistent tuberculosis.
Аinura Zhoshybaeva +6 more
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Dynamic Lysine Acetylation Disrupts Isocitrate Lyase Function and Enables Metabolic Optimisation [PDF]
Microbial BiotechnologyProteomic studies have suggested that Escherichia coli isocitrate lyase (ICL) undergoes multiple acetylation events, partially inhibiting its activity. However, the molecular basis of this regulation and the contribution of individual lysine residues had
Adrián Martínez‐Vivancos +6 more
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¹³C metabolic flux analysis identifies an unusual route for pyruvate dissimilation in mycobacteria which requires isocitrate lyase and carbon dioxide fixation. [PDF]
PLoS Pathogens, 2011 Mycobacterium tuberculosis requires the enzyme isocitrate lyase (ICL) for growth and virulence in vivo. The demonstration that M. tuberculosis also requires ICL for survival during nutrient starvation and has a role during steady state growth in a ...
Dany J V Beste +9 more
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Inhibitory Effects of Nitrogenous Metabolites from a Marine-Derived Streptomyces bacillaris on Isocitrate Lyase of Candida albicans [PDF]
Marine Drugs, 2022 Two nitrogenous metabolites, bacillimide (1) and bacillapyrrole (2), were isolated from the culture broth of the marine-derived actinomycete Streptomyces bacillaris.
Beomkoo Chung +9 more
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