The Role of Isocitrate Lyase (ICL1) in the Metabolic Adaptation of Candida albicans Biofilms. [PDF]
Jundishapur J Microbiol, 2016 Background A major characteristic of Candida biofilm cells that differentiates them from free-floating cells is their high tolerance to antifungal drugs.
Ishola OA +7 more
europepmc +2 more sources
Inhibitory Effects of Epipolythiodioxopiperazine Fungal Metabolites on Isocitrate Lyase in the Glyoxylate Cycle of Candida albicans [PDF]
Marine Drugs, 2021 Four epipolythiodioxopiperazine fungal metabolites (1–4) isolated from the sponge-derived Aspergillus quadrilineatus FJJ093 were evaluated for their capacity to inhibit isocitrate lyase (ICL) in the glyoxylate cycle of Candida albicans. The structures of
Ji-Yeon Hwang +7 more
doaj +2 more sources
Isocitrate lyase activity in halophilic archaea [PDF]
FEMS Microbiology Letters, 1995 Eight species of halophilic Archaea were tested for the presence of isocitrate lyase activity. High activities (up to 100 nmol min−1 mg protein−1) were detected in Haloferax mediterranei and Haloferax volcanii when grown in medium containing acetate as the principal carbon source. Little activity was found in representatives of the genera Halobacterium
Aharon Oren, Peter Gurevich
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Potential inhibitors for isocitrate lyase of Mycobacterium tuberculosis and non-M. tuberculosis: a summary. [PDF]
Biomed Res Int, 2015 Isocitrate lyase (ICL) is the first enzyme involved in glyoxylate cycle. Many plants and microorganisms are relying on glyoxylate cycle enzymes to survive upon downregulation of tricarboxylic acid cycle (TCA cycle), especially Mycobacterium tuberculosis (
Lee YV, Wahab HA, Choong YS.
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Regulation of the icl1 Gene Encoding the Major Isocitrate Lyase in Mycobacterium smegmatis. [PDF]
J Bacteriol, 2021 Ko EM +5 more
europepmc +3 more sources
An isocitrate lyase gene-deleted strain of Nocardia seriolae in live attenuated vaccine development against fish nocardiosis [PDF]
Frontiers in Veterinary ScienceBackgroundFish nocardiosis caused by Nocardia seriolae is a severe bacterial disease in aquaculture, causing significant economic losses. The effectiveness of antibiotics in dealing with nocardiosis induced by N. seriolae is not satisfactory.
Guanying Lin +8 more
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Suvanine Sesterterpenes from a Tropical Sponge Coscinoderma sp. Inhibit Isocitrate Lyase in the Glyoxylate Cycle [PDF]
Marine Drugs, 2014 The glyoxylate cycle is a sequence of anaplerotic reactions catalyzed by the key enzymes isocitrate lyase (ICL) and malate synthase (MLS). Mutants of Candida albicans lacking ICL are markedly less virulent in mice than the wild-type.
So-Hyoung Lee +5 more
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Regulation by Glutathionylation of Isocitrate Lyase from Chlamydomonas reinhardtii [PDF]
Journal of Biological Chemistry, 2009 Post-translational modification of protein cysteine residues is emerging as an important regulatory and signaling mechanism. We have identified numerous putative targets of redox regulation in the unicellular green alga Chlamydomonas reinhardtii. One enzyme, isocitrate lyase (ICL), was identified both as a putative thioredoxin target and as an S ...
Bedhomme M +7 more
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Study on the differences in sugar-acid metabolism of Sweet Orange ‘Newhall’ with different rootstocks [PDF]
BMC Plant BiologyBackground Citrus rootstock selection plays a critical role in modulating sugar-acid metabolism, thereby influencing fruit flavor quality. This study systematically investigated the dynamic changes in sugar and acid components, key enzyme activities, and
Qingqing Ma +14 more
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Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis [PDF]
Nature Communications, 2014 Madhumitha Nandakumar +2 more
semanticscholar +2 more sources