Results 61 to 70 of about 74,679 (236)

Drug‐coated balloons: From conventional designs to next‐generation innovations in vascular therapy

BMEMat, EarlyView.
This review traces the evolution of drug‐coated balloons (DCBs) from conventional designs to next‐generation platforms. We highlight innovations in balloon engineering, coating technologies, and therapeutic agents that enhance localized drug delivery while addressing challenges in efficiency, safety, and biocompatibility for vascular and emerging non ...
Lu Zhang, Jiawei Cui, Jin Wang, Manfred F. Maitz, Rifang Luo, Yunbing Wang   +5 more
wiley   +1 more source

Associations Between Glutathione-S-Transferase Genotypes and Bronchial Hyperreactivity Patients With Di-isocyanate Induced Asthma. A Follow-Up Study

Frontiers in Medicine, 2019
Introduction: Di-isocyanates TDI (toluene di-isocyanate), MDI (diphenylmethane di-isocyanate), and HDI (hexamethylene di-isocyanate) are the most common chemicals causing occupational asthma. Di-isocyanate inhalation has been reported to induce oxidative
Jussi Leppilahti, Jussi Leppilahti, Marja-Leena Majuri, Timo Sorsa, Timo Sorsa, Timo Sorsa, Ari Hirvonen, Ari Hirvonen, Päivi Piirilä   +8 more
doaj   +1 more source

Strain Release of 1‐Azabicyclo[1.1.0]butanes as a Gateway to Highly Functionalized Azetidines: New Strategies and Structural Motifs

Chemistry – A European Journal, EarlyView.
Over the past decade, the interest in azetidines has continuously risen, by virtue of their highly appealing pharmaceutical properties. Monocyclic, spirocyclic, and bridged azetidines can be accessed by leveraging 1‐azabicyclo[1.1.0]butanes as precursors.
Yuri Gelato, Philipp Natho, Marco Colella, Renzo Luisi   +3 more
wiley   +1 more source

Synthesis and Reactivity of 3‐Aminosydnones in Cycloaddition Reactions With Alkynes

Chemistry – A European Journal, EarlyView.
The synthesis, functionalization, and reactivity as dipoles of 3‐aminosydnones have been investigated. These neglected compounds undergo smooth cycloaddition reactions with strained alkynes, leading to 1‐aminopyrazoles. ABSTRACT We present in this article the synthesis, functionalization, and properties of 3‐aminosydnones, a forgotten class of ...
Apolline Dominic, Timothée D'anfray, Guillaume Force, David‐Alexandre Buisson, Maxime Tricoire, Alexis Leblais, Davide Audisio, Frédéric Taran   +7 more
wiley   +1 more source

Mechanochemical Amidation Mediated by 1,1’‐Oxalyldiimidazole for the Synthesis of Agrochemicals

Chemistry – A European Journal, EarlyView.
Mechanochemical amidation using 1,1'‐oxalyldiimidazole (ODI) overcomes limitations of 1,1’‐carbonyl diimidazole (CDI) as coupling agent by enabling the efficient mechanochemical synthesis of three marketed agrochemicals from deactivated carboxylic acids.
Andrea Casagrande, Rubén Solorzano‐Rodriguez, Maria Carta, Francesco Delogu, Joris Vezzani, Allan Niidu, Evelina Colacino   +6 more
wiley   +1 more source

Precision Chemistry for Protein Lysine Modification

Chemistry – A European Journal, EarlyView.
Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley   +1 more source

Industrial Byproducts as Adhesive Allies: Unraveling the Role of Proteins and Isocyanates in Polyurethane Wood Bonding

BioResources
Wooden structures are becoming increasingly popular in the construction world. However, these structures often rely on synthetic adhesives, raising concerns about the environmental risks associated with their chemical composition.
Alex Mary, Pierre Blanchet, Simon Pepin, Aurélien Hermann, Stéphane Charron, Véronic Landry   +5 more
doaj   +2 more sources

Improving the Mechanical Properties of Biodegradable Polyhydroxyalkanoates via PHA–PHA Block‐Copolymer Synthesis

Chemistry – A European Journal, EarlyView.
Covalent linkage of a highly crystalline PHBV with a ductile P3HB4HB is shown to produce block copolymers with markedly enhanced extensibility and toughness, outperforming equivalent blends. The results demonstrate that polymer architecture, not composition alone, governs mechanical response, offering a route to biodegradable materials that combine ...
Katrin Blandine Kockler, Paul Lant, Steven Pratt, Bronwyn Laycock   +3 more
wiley   +1 more source

Theoretical Framework for Predicting Dynamic Covalent Exchange Based on Proton Affinities and Proton‐Transfer Assistance

Chemistry – A European Journal, EarlyView.
Proton‑transfer catalysis controls acylsemicarbazide dissociation, linking proton affinity to exchange kinetics and enabling predictive design of robust, tunable dynamic covalent networks. ABSTRACT We provide design principles for predicting bond exchange kinetics in acylsemicarbazide (ASC)‐based systems that can be applied to tuning the properties of ...
Siebe Lekanne Deprez, Stefan J. D. Maessen, Angelina N. van Dam, Celine Nieuwland, Pascal Vermeeren, Anja R. A. Palmans, Célia Fonseca Guerra   +6 more
wiley   +1 more source

Elimination kinetics of diisocyanates after specific inhalative challenges in humans: mass spectrometry analysis, as a basis for biomonitoring strategies

Journal of Occupational Medicine and Toxicology, 2011
Background Isocyanates are some of the leading occupational causes of respiratory disorders, predominantly asthma. Adequate exposure monitoring may recognize risk factors and help to prevent the onset or aggravation of these aliments.
Lemiere Catherine, Merget Rolf, Nowak Dennis, Budnik Lygia T, Baur Xaver   +4 more
doaj   +1 more source