Results 181 to 190 of about 35,027 (292)

Reducing Cathodic Drift during Isoelectric Focusing Using Microscale Immobilized pH Gradient Gels. [PDF]

Anal Chem
Lomeli G, Herr AE.
europepmc   +1 more source

Mixed‐mode membrane chromatography: mechanistic‐modeling‐based optimization and scale‐up of antibody charge variant separation using a novel membrane adsorber

Journal of Chemical Technology &Biotechnology, Volume 101, Issue 7, Page 1407-1419, July 2026.
Abstract BACKGROUND Efficient manufacturing of complex biopharmaceuticals increasingly relies on innovative downstream processing strategies. Membrane chromatography offers a promising alternative to resin‐based systems by enabling high‐throughput separations at elevated flow rates. Typically used in flow‐through mode, its industrial applications range
Jan Hedrich, Rita Steigmiller, Viktor Simaev, Romas Skudas, Michael Schulte, Mathias Hafner, Christian Frech   +6 more
wiley   +1 more source

Development of a step‐gradient simulated moving bed process for the polishing of monoclonal antibodies with anion exchange chromatography

Journal of Chemical Technology &Biotechnology, Volume 101, Issue 7, Page 1359-1369, July 2026.
Abstract BACKGROUND In recent years, biopharmaceutical applications in medicine have seen explosive growth and the need for efficient, rapid and inexpensive purification of these targets is the topic of tremendous research and development. The need to improve process efficiency has been an active area of investigation due to the tremendous potential ...
Yasmina MJ Harsy, Jonas Wege, Anthony Grabski, Romain Dabre, Egbert Müller, Carsten‐René Arlt   +5 more
wiley   +1 more source

Development of a novel, high-throughput imaged capillary isoelectric focusing-Western method to characterize charge heterogeneity of monoclonal antibody heavy and light chains. [PDF]

MAbs
Dhulipala G, Broszeit A, Lu K, Palackal N, Pyles E.   +4 more
europepmc   +1 more source

In silico prediction and structural characterization of multifunctional bioactive peptides released from olive proteins

Journal of the Science of Food and Agriculture, Volume 106, Issue 9, Page 5463-5482, July 2026.
Abstract BACKGROUND Olive (Olea europaea L.) byproducts, such as seeds and leaves, are abundant agro‐industrial residues and represent underexplored protein sources with potential health relevance. However, the repertoire of bioactive peptides that may be released from olive proteins during gastrointestinal digestion remains poorly characterized.
Teresa Gonzalez‐de la Rosa, Luna Barrera‐Chamorro, Africa Fernandez‐Prior, Elvira Marquez‐Paradas, Maria Torrecillas‐Lopez, Fernando Rivero‐Pino, Sergio Montserrat‐de la Paz   +6 more
wiley   +1 more source

Arrayed isoelectric focusing using photopatterned multi-domain hydrogels. [PDF]

Electrophoresis, 2018
Yamauchi KA, Tentori AM, Herr AE.
europepmc   +1 more source

Transferrin isoelectric focusing for the investigation of congenital disorders of glycosylation: analysis of a ten-year experience in a Brazilian center. [PDF]

J Pediatr (Rio J), 2020
Magalhães APPS, Burin MG, Souza CFM, de Bitencourt FH, Sebastião FM, Silva TO, Vairo FPE, Schwartz IVD.   +7 more
europepmc   +1 more source

Antithrombin: Deficiency, Diversity, and the Future of Diagnostics

Mass Spectrometry Reviews, Volume 45, Issue 4, Page 745-768, July/August 2026.
ABSTRACT Our healthcare system provides reactive sick‐care, treating patients after symptoms have appeared by prescription of generic and often suboptimal therapy. This strategy brings along high costs and high pressure which is not sustainable.
Mirjam Kruijt, Christa M. Cobbaert, L. Renee Ruhaak   +2 more
wiley   +1 more source

Development of an imaged capillary isoelectric focusing method for characterizing the surface charge of mRNA lipid nanoparticle vaccines. [PDF]

Electrophoresis, 2019
Loughney JW, Minsker K, Ha S, Rustandi RR.   +3 more
europepmc   +1 more source

NToxSEM: Enhancing prediction of neurotoxic peptides and neurotoxins using a stacked ensemble‐based multimodal framework

Protein Science, Volume 35, Issue 7, July 2026.
Abstract The safety assessment of therapeutic proteins and genetically modified (GM) organisms relies heavily on the rapid and accurate prediction of peptides, and proteins that exhibit neurotoxic activity. Since experimental methods are time‐consuming and costly, they are not technically suitable for the cost‐effective characterization of neurotoxic ...
Watshara Shoombuatong, Nalini Schaduangrat, S. M. Hasan Mahmud, Saeed Ahmed   +3 more
wiley   +1 more source