Results 221 to 230 of about 60,313 (296)

Cationic mRNA Lipid Nanoparticles for Ex Vivo NanoCAR‐T Cell Engineering

Advanced Science, Volume 13, Issue 24, 27 April 2026.
This study compares charge‑neutral and cationic lipidnanoparticles (LNPs) for ex vivo mRNA delivery to T cells, revealing distinctdependencies on medium composition and T cell activation. Where conventional LNPs benefit from ApoE‐dependent T cell targeting, cationic DOTAP‑modified LNPs mediate unspecific charge‑dependent transfection.
Laure Harinck, Stijn De Munter, Margo De Velder, Joline Ingels, Dominika Berdecka, Ine Lentacker, Winnok H. De Vos, Bart Vandekerckhove, Kevin Braeckmans, Koen Raemdonck   +9 more
wiley   +1 more source

Nanozymes for Liver Disease Therapy: Advances in Catalytic Activity, Targeting Strategies, and Clinical Translation

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Nanozymes, as enzyme‐mimicking nanomaterials, exhibit unique catalytic properties for the treatment of liver diseases. By regulating redox homeostasis, modulating immune responses, and enabling targeted delivery, nanozymes overcome the limitations of natural enzymes.
Xiandi Meng, Ge Zhu, Siyu Sun, Wenbo Yao, Yuning Zhang, Yong‐Guang Yang, Tianmeng Sun   +6 more
wiley   +1 more source

Effect of Joule heating on isoelectric focusing of proteins in a microchannel. [PDF]

Biomicrofluidics, 2014
Yoo K, Shim J, Dutta P.
europepmc   +1 more source

Organic Electrochemical Transistors and Foreign Body Reaction: First Steps Toward Long‐Term Implantable Biosensing

Advanced Electronic Materials, Volume 12, Issue 7, 6 April 2026.
Organic Electrochemical Transistors (OECT) have been applied as implanted sensors in recent years. However, Foreign Body Reaction (FBR) effects on OECT performance are still underexplored. Here, we analyze OECT operation when covered by FBR‐related proteins in an in vitro scenario.
Henrique Frulani de Paula Barbosa, Titinun Nuntapramote, Ankush Kumar, Sander van den Driesche, Michael J. Vellekoop, Dorothea Brüggemann, Björn Lüssem   +6 more
wiley   +1 more source

Isoelectric focusing in a drop. [PDF]

Langmuir, 2011
Weiss NG, Hayes MA, Garcia AA, Ansari RR.   +3 more
europepmc   +1 more source

Tailoring Multiphasic Protein Condensates via Liquid‐Liquid Phase Separation

Aggregate, Volume 7, Issue 4, April 2026.
Multiphasic protein condensates transform structural organizations and deliver nucleic acids. ABSTRACT Many of the membraneless organelles inside cells are multiphasic condensates with complex structural organizations driven by the demixing of phase‐separating proteins.
Yongxu Han, Kai Cheng, Kongqi Chen, Zhiyi Xu, Hao Jiang, Bin Zeng, Manjia Li, Fei Sun, Xiangze Zeng, Sijie Chen, Jiang Xia   +10 more
wiley   +1 more source

ERK and AKT phosphorylation status in lung cancer and emphysema using nanocapillary isoelectric focusing. [PDF]

BMJ Open Respir Res, 2016
Crosbie PA, Crosbie EJ, Aspinall-O'Dea M, Walker M, Harrison R, Pernemalm M, Shah R, Joseph L, Booton R, Pierce A, Whetton AD.   +10 more
europepmc   +1 more source

Autosomal Dominant Erythrocytosis Caused by Non‐Renal Erythropoietin (EPO) Due to EPO c.‐136 G>A Germline Mutation

American Journal of Hematology, Volume 101, Issue 4, Page 784-793, April 2026.
A novel erythropoietin (EPO) promoter mutation (c.‐136 G>A) causes autosomal dominant erythrocytosis via non‐renal expression of EPO. ABSTRACT We previously reported a five‐generation kindred with autosomal dominant erythrocytosis associated with a novel germline promoter variant in the erythropoietin (EPO) gene (EPO c.‐136 G>A).
Lucie Lanikova, Dusan Hrckulak, Veronika Zimolova, Felipe R. Lorenzo, Jihyun Song, Katerina Vecerkova, Olga Babosova, Linda Berkova, Vladimir Korinek, Steve Elliott, Josef T. Prchal   +10 more
wiley   +1 more source

Capillary Isoelectric Focusing of Akt Isoforms Identifies Highly Dynamic Phosphorylation in Neuronal Cells and Brain Tissue. [PDF]

J Biol Chem, 2016
Schrötter S, Leondaritis G, Eickholt BJ.   +2 more
europepmc   +1 more source

Creative and Adaptive Solutions for Early Diagnosis of Sickle Cell Disease in Sub‐Saharan Africa

American Journal of Hematology, Volume 101, Issue S1, Page 17-32, April 2026.
ABSTRACT Many of the children with sickle cell disease born in sub‐Saharan Africa remain undiagnosed and untreated. Increasing capacity and infrastructure to support diagnostic and screening programs in high income countries have enabled near universal survival into adulthood.
Luke R. Smart, Catherine I. Segbefia, Isaac Odame   +2 more
wiley   +1 more source