Biotechnology and Bioengineering, EarlyView.ABSTRACT Polysorbate‐degrading host cell proteins (HCPs) represent a critical challenge in the manufacturing of monoclonal antibody therapeutics due to their potential to persist during downstream processing. While their enzymatic activity has been characterized, the role of direct HCP‐mAb interactions, particularly those involving polysorbate ...
Melanie Maier +3 more
wiley +1 more source
Charged Poly(N-isopropylacrylamide) Nanogels for the Stabilization of High Isoelectric Point Proteins. [PDF]
ACS Biomater Sci Eng, 2021 Macdougall LJ +6 more
europepmc +1 more source
Biotechnology Progress, EarlyView.Abstract A rapid assessment of manufacturability for drug candidates is crucial for advancing a prospective biotherapeutic from a candidate to a bulk drug substance. A lot‐to‐lot approach to manufacturability is adopted where each biologic batch is assessed for manufacturability as a bulk, unfractionated pool.
Solomon Isu +6 more
wiley +1 more source
Measurement of Isoelectric Point of Sandstone and Carbonate Rock for Monitoring Water Encroachment [PDF]
, 2014 Mohd Zaidi Jaafar +2 more
openalex +1 more source
Carbon Energy, EarlyView.Keggin‐type Al‐POM‐coated silica achieves selective surface oxidation of amorphous carbon through electrostatic attraction and proton‐coupled oxidation, tailoring interfacial properties for lithium‐ion batteries and semiconductor processes. ABSTRACT Amorphous carbon is widely used in energy storage and semiconductor technologies, where surface ...
Ganggyu Lee +13 more
wiley +1 more source
Buffer pH-Driven Electrokinetic Concentration of Proteins in a Straight Microfluidic Channel
SurfacesWe present a buffer-pH-modulated electrokinetic concentration strategy in MEMS microchannels that harnesses simple pH shifts to neutralize and charge proteins, reversibly “pausing” them at a planar electric-gate electrode by tuning to their isoelectric ...
Diganta Dutta +3 more
doaj +1 more source
Virtual 2D mapping of the viral proteome reveals host-specific modality distribution of molecular weight and isoelectric point. [PDF]
Sci Rep, 2021 Mohanta TK +3 more
europepmc +1 more source
Efficient uses of some types of surfactant products [PDF]
The present work is part of a more complex study referring to chemical substances known under the name of „surfactants” or „tensioactive agents” which can alter the conductivity of fibers, textile materials, etc.
Camelia Georgeta CALIN +2 more
core
Development of methods for capillary isoelectric focusing of dairy proteins : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Chemistry at Massey University [PDF]
, 2006 Capillary Isoelectric Focusing (CIEF) is a high-resolution technique which can be applied to the separation and characterisation of complex biological mixtures such as dairy proteins.
Gapper, Leyton William
core
Inherited metabolic epilepsies–established diseases, new approaches
Epilepsia Open, EarlyView.Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source