Results 11 to 20 of about 48,809 (249)

The immunolocalization of HIF‐2α, GLUT1 and CAIX in porcine oviduct during the estrous cycle

The Anatomical Record, Volume 306, Issue 1, Page 176-186, January 2023., 2023
Abstract Oxygen (O2) rates in the oviduct are essential to human and animal reproduction. These rates are regulated by the activity of hypoxia markers such as the hypoxia‐inducible factors (HIFs), the glucose transporters (GLUT), and the carbonic anhydrase (CA).
Ester Párraga‐Ros, Rafael Latorre‐Reviriego, Mónica Aparicio‐González, Talía Boronat‐Belda, Octavio López‐Albors   +4 more
wiley   +1 more source

The brain‐before‐heart strategy for coronary artery bypass grafting in the severely atherosclerotic aorta: A single‐institution experience

Clinical Cardiology, Volume 45, Issue 12, Page 1264-1271, December 2022., 2022
Abstract Background Severe atherosclerosis of the ascending aorta (SAA) in patients undergoing surgical revascularization by coronary artery bypass grafting (CABG) is becoming an increasing problem as more elderly patients are diagnosed with coronary artery disease.
Rakan I. Nazer, Ali M. Albarrati
wiley   +1 more source

Molecular and cellular paradigms of multidrug resistance in cancer

Cancer Reports, Volume 5, Issue 12, December 2022., 2022
Abstract Background The acquisition of resistance to chemotherapy is a major hurdle in the successful application of cancer therapy. Several anticancer approaches, including chemotherapies, radiotherapy, surgery and targeted therapies are being employed for the treatment of cancer.
Foram U. Vaidya, Abu Sufiyan Chhipa, Vinita Mishra, Vishal Kumar Gupta, Shiv Govind Rawat, Ajay Kumar, Chandramani Pathak   +6 more
wiley   +1 more source

Pharmacokinetics, Bioavailability, and Swallowing Safety With Riluzole Oral Film

Clinical Pharmacology in Drug Development, Volume 12, Issue 1, Page 57-64, January 2023., 2023
Abstract Dysphagia is highly prevalent in patients with amyotrophic lateral sclerosis (ALS). Riluzole is a US Food and Drug Administration‐approved treatment for ALS. Riluzole oral film (ROF; Exservan™) contains riluzole in a polymer‐based film matrix.
James Wymer, Stephen Apple, Antoinette Harrison, Bryan Alan Hill   +3 more
wiley   +1 more source

KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential

Medicinal Research Reviews, Volume 43, Issue 1, Page 237-287, January 2023., 2023
Abstract The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective genes related to oxidative stress, inflammation, and protein homeostasis, among other processes.
Enrique Crisman, Pablo Duarte, Esteban Dauden, Antonio Cuadrado, María Isabel Rodríguez‐Franco, Manuela G. López, Rafael León   +6 more
wiley   +1 more source

Sulfonamide-Bearing Pyrazolone Derivatives as Multitarget Therapeutic Agents: Design, Synthesis, Characterization, Biological Evaluation, In Silico ADME/T Profiling and Molecular Docking Study. [PDF]

Pharmacol Res Perspect
ABSTRACT The research and design of new inhibitors for the treatment of diseases such as Alzheimer's disease and glaucoma through inhibition of cholinesterases (ChEs; acetylcholinesterase, AChE and butyrylcholinesterase, BChE) and carbonic anhydrase enzymes are among the important targets.
Lolak N, Akocak S, Topal M, Koçyiğit ÜM, Işık M, Türkeş C, Topal F, Durgun M, Beydemir Ş.   +8 more
europepmc   +2 more sources

Seleção de genótipos de aceroleira assistida por marcadores isoenzimáticos visando à resistência a Meloidogyne incognita raça 2 Genotype selection of Barbados cherry using iso-enzymatic markers for resistance to Meloidogyne incognita race 2

Revista Brasileira de Fruticultura, 2008
A cultura da aceroleira despertou um grande interesse do mercado consumidor, tendo em vista o alto teor de vitamina C (ácido ascórbico), que varia entre 1.325 a 2.250 mg por 100 mL de suco.
Jackeline Gadé de Araujo Rossiter, Rosimar dos Santos Musser, Luiza Suely Semen Martins, Elvira Maria Regis Pedrosa, Jeane Emilli de Medeiros   +4 more
doaj   +1 more source

Ultrafast Early Warning of Heart Attacks through Plasmon‐Enhanced Raman Spectroscopy using Collapsible Nanofingers and Machine Learning

Small, Volume 19, Issue 2, January 11, 2023., 2023
Here, an ultrafast early heart‐attack warning system is invented through Surface‐enhanced Raman spectroscopy using collapsible nanofingers and machine learning (ML). By using functionalized nanofinger structure, it allows for trace amounts of biomarkers to be detected. Raman spectra are constructed for predictive analytics using ML models.
Zerui Liu, Deming Meng, Guangxu Su, Pan Hu, Boxiang Song, Yunxiang Wang, Junhan Wei, Hao Yang, Tianyi Yuan, Buyun Chen, Tse‐Hsien Ou, Sushmit Hossain, Matthew Miller, Fanxin Liu, Wei Wu   +14 more
wiley   +1 more source

Isoenzyme polymorphism of almond genotypes selected in the region of northern Serbia

Horticultural Science, 2010
Isoenzyme polymorphism was studied in 20 almond (Prunus dulcis [Mill.] D.A. Webb) genotypes selected from seedling populations of unknown almond cultivars in the region of northern Serbia (Vojvodina). Fourteen enzyme systems were studied using the method
S. Čolić, D. Milatović, D. Nikolić, G. Zec   +3 more
doaj   +1 more source

Activities of amine oxidase, peroxidase and catalase in seedlings of Pisum sativum L. under different light conditions

Plant, Soil and Environment, 2003
The activities of amine oxidase, peroxidase and catalase were studied in 12 cultivars of field pea (Pisum sativum L.) and one accession of wild pea (Pisum sativum subsp. transcaucasicum).
L. Luhová, A. Lebeda, D. Hedererová, P. Peč   +3 more
doaj   +1 more source