Results 51 to 60 of about 48,809 (249)

Substrate-Enzyme Interaction in Pig Liver Esterase [PDF]

open access: yesarXiv, 2012
Force field and first principles molecular dynamics simulations on complexes of pig liver esterase (pig liver isoenzymes and a mutant) and selected substrates (1-phenyl-1-ethyl acetate, 1- phenyl-2-butylacetate, proline-{\beta}-naphthylamide and methyl butyrate) are presented.
arxiv  

Improved C5‐amide bioisosteres for human neuraminidase 1 inhibitors based on 2‐deoxy‐2,3‐didehydro‐N‐acetyl neuraminic acid (DANA)

open access: yesChemMedChem, Accepted Article.
Neuraminidase enzymes (NEU) play a crucial role in many physiological and pathological conditions. Humans have four isoenzymes of NEU and their specific roles continue to be investigated. Isoenzyme‐selective inhibitors are needed as research tools and may lead to future therapeutics.
Mostafa Radwan   +2 more
wiley   +1 more source

Carborane‐based Analogues of Celecoxib and Flurbiprofen, their COX Inhibition Potential and COX Selectivity Index

open access: yesChemMedChem, Accepted Article.
The cylcooxygenase isoforms COX‐1 and COX‐2 are involved in the production of prostaglandins in physiological and pathological processes. The overexpression of COX‐2 under inflammatory conditions as well as its role in cancer and neurodegenerative diseases necessitates the need to develop and improve non‐steroidal anti‐inflammatory drugs.
Lea Ueberham   +8 more
wiley   +1 more source

Comparison of methods for obtaining doubled haploids of carrot

open access: yesActa Societatis Botanicorum Poloniae, 2017
Doubled haploid lines of carrot can be obtained through androgenesis in anther cultures and in isolated microspore cultures. The two methods were compared using three carrot cultivars (‘Kazan F1’, ‘Feria F1’, and ‘Narbonne F1’) at the androgenesis ...
Waldemar Kiszczak   +4 more
doaj   +1 more source

Genetic Analysis of Izoenzymes Polymorphisms in Silkworm (Bombyx mori L.) Strains - doi: 10.4025/actascibiolsci.v35i2.13102

open access: yesActa Scientiarum: Biological Sciences, 2012
This work carried out to evaluates the polymorhism in the silkworm of different lineages using the isoenzymes electrophoresis to detect biochemical markers and to investigate the genetics of populations for those lineages.
Ludimilla Ronqui   +2 more
doaj   +1 more source

Establishment of a Prognostic Risk Score Model Based on Bioinformatics for Ferroptosis and Cuproptosis‐Related Genes in Gastric Cancer

open access: yesCancer Nexus, EarlyView.
ABSTRACT Background Gastric cancer (GC) stands out as one of the most prevalent forms of malignant tumors globally, characterized by a notably high mortality rate. In spite of progress in medical science and treatment alternatives, the survival rate over 5 years continues to stay under 40%.
Yang Shaokang   +5 more
wiley   +1 more source

Molecular typing of Leishmania (Leishmania) amazonensis and species of the subgenus Viannia associated with cutaneous and mucosal leishmaniasis in Colombia: A concordance study

open access: yesBiomédica: revista del Instituto Nacional de Salud, 2018
Introduction: Multilocus enzyme electrophoresis (MLEE) is the reference standard for the characterization of Leishmania species. The test is restricted to specialized laboratories due to its technical complexity, cost, and time required to obtain results.
Clemencia Ovalle-Bracho   +3 more
doaj   +1 more source

Recent Advancements in Microfluidic Biosensors for Clinical Applications

open access: yesiLABMED, EarlyView.
The combination of low‐consumption microfluidic chips and high‐sensitivity biosensors enables rapid and accurate detection of complex target analytes. This integrated system holds significant potential for applications in disease diagnosis, health monitoring, and treatment management.
Haiyan Wang, Wenjuan Wu
wiley   +1 more source

The influence of microbiome‐derived amino acids metabolites in shaping the glioma immunosuppressive microenvironment

open access: yesInterdisciplinary Medicine, EarlyView.
Left: The disruption of the balance between carcinogenic bacteria and probiotics mediated by antibiotics, protein, and glucose intake. Middle: The gut microbiota‐derived amino acids, primarily through tryptophan, tyrosine, arginine, and branched‐chain amino acid pathways, regulate glioma development via mechanisms such as AHR activation, metabolic ...
Qianquan Ma   +10 more
wiley   +1 more source

Physiological changes in hybrid Brachiaria cv. Mulato II after accelerated aging to overcome dormancy

open access: yesJournal of Seed Science
: To evaluate the effect of accelerated aging to overcome dormancy of hybrid Brachiaria cv. Mulato II (U. brizantha x U. decumbens x U. ruziziensis), seeds were collected from two lots with and without scarification, submitted to 42 °C and high humidity (
Diego de Sousa Pereira   +4 more
doaj   +1 more source

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