Isoflurane anesthesia promotes cognitive impairment by inducing expression of β-amyloid protein-related factors in the hippocampus of aged rats. [PDF]
PLoS ONE, 2017 Isoflurane anesthesia has been shown to be responsible for cognitive impairment in Alzheimer's disease (AD) and development of AD in the older age groups.
Shuai Zhang +6 more
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Interpreting Neuroendocrine Hormones, Corticosterone, and Blood Glucose to Assess the Wellbeing of Anesthetized Rats during Euthanasia [PDF]
, 2018 Current recommendations for assessing animal wellbeing during euthanasia suggest that measuring neuroendocrine hormones-such as ACTH, noradrenaline, and adrenaline-is preferable to measuring corticosterone and blood glucose because of the sensitivity of ...
Hickman, Debra L.
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Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aβ oligomerization. [PDF]
PLoS ONE, 2011 Accumulation and deposition of β-amyloid protein (Aβ) are the hallmark features of Alzheimer's disease. The inhalation anesthetic isoflurane has been shown to induce caspase activation and increase Aβ accumulation.
Yiying Zhang +8 more
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Anesthetic isoflurane increases phosphorylated tau levels mediated by caspase activation and Aβ generation. [PDF]
PLoS ONE, 2012 Anesthetic isoflurane has been shown to promote Alzheimer's disease (AD) neuropathogenesis by inducing caspase activation and accumulation of β-amyloid (Aβ). Phosphorylation of tau protein is another important feature of AD neuropathogenesis.
Yuanlin Dong +4 more
doaj +1 more source
Comparison of the effects of two anesthetics, isoflurane and urethane, on bladder function in rats
Journal of Pharmacological Sciences, 2023 We compared the effects of two anesthetics, isoflurane and urethane on bladder function in rats. Arterial pressure, cystometry (CMG), and rhythmic bladder contractions (RBCs) under isovolumetric conditions, mechanosensitive single-unit afferent ...
Naoki Aizawa, Tomoe Fujita
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Activation of D1 Dopamine Receptors Induces Emergence from Isoflurane General Anesthesia [PDF]
, 2012 Background: A recent study showed that methylphenidate induces emergence from isoflurane anesthesia. Methylphenidate inhibits dopamine and norepinephrine reuptake transporters.
Brown, Emery N. +3 more
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Frontiers in Physiology, 2022 Inhalation anesthetics isoflurane and sevoflurane have been widely used in clinical practice for anesthesia. However, the molecular mechanisms underlying the faster recovery from sevoflurane anesthesia than isoflurane anesthesia remain largely ...
Zongyuan Ma +4 more
doaj +1 more source
PLoS ONE, 2015 This study demonstrates that in mice subjected to hypoxia-ischemia (HI) brain injury isoflurane anesthesia initiated upon reperfusion limits a release of mitochondrial oxidative radicals by inhibiting a recovery of complex-I dependent mitochondrial ...
Sergey A Sosunov +5 more
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Frontiers in Behavioral Neuroscience, 2020 Isoflurane contributes to cognitive deficits when used as a general anesthetic, and so does sleep deprivation (SD). Patients usually suffer from insomnia before an operation due to anxiety, fear, and other factors. It remains unclear whether preoperative
Kai Zhang +13 more
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Volatile anesthetics, not intravenous anesthetic propofol bind to and attenuate the activation of platelet receptor integrin αIIbβ3. [PDF]
PLoS ONE, 2013 In clinical reports, the usage of isoflurane and sevoflurane was associated with more surgical field bleeding in endoscopic sinus surgeries as compared to propofol.
Koichi Yuki +3 more
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