Results 41 to 50 of about 301,160 (383)

Inhibiting the NLRP3 Inflammasome With MCC950 Ameliorates Isoflurane-Induced Pyroptosis and Cognitive Impairment in Aged Mice

Frontiers in Cellular Neuroscience, 2018
Nod-like receptor protein 3 (NLRP3) inflammasome activation has been implicated in the pathogenesis of general anesthesia (GA)-induced neuroinflammation and cognitive impairment in aged rodents.
Yunxia Fan, Liwu Du, Qun Fu, Zhi-qiang Zhou, Jingyu Zhang, Guo-min Li, Jing Wu   +6 more
semanticscholar   +1 more source

Minocycline attenuates cognitive impairment induced by isoflurane anesthesia in aged rats. [PDF]

PLoS ONE, 2013
Postoperative cognitive dysfunction (POCD) is a clinical phenomenon characterized by cognitive deficits in patients after anesthesia and surgery, especially in geriatric surgical patients. Although it has been documented that isoflurane exposure impaired
Feijuan Kong, Shuping Chen, Yuan Cheng, Leilei Ma, Huishun Lu, Honghai Zhang, Wenwen Hu   +6 more
doaj   +1 more source

Anesthetic isoflurane increases phosphorylated tau levels mediated by caspase activation and Aβ generation. [PDF]

PLoS ONE, 2012
Anesthetic isoflurane has been shown to promote Alzheimer's disease (AD) neuropathogenesis by inducing caspase activation and accumulation of β-amyloid (Aβ). Phosphorylation of tau protein is another important feature of AD neuropathogenesis.
Yuanlin Dong, Xu Wu, Zhipeng Xu, Yiying Zhang, Zhongcong Xie   +4 more
doaj   +1 more source

Sleep Deprivation Aggravates Cognitive Impairment by the Alteration of Hippocampal Neuronal Activity and the Density of Dendritic Spine in Isoflurane-Exposed Mice

Frontiers in Behavioral Neuroscience, 2020
Isoflurane contributes to cognitive deficits when used as a general anesthetic, and so does sleep deprivation (SD). Patients usually suffer from insomnia before an operation due to anxiety, fear, and other factors. It remains unclear whether preoperative
Kai Zhang, Kai Zhang, Naqi Lian, Naqi Lian, Ran Ding, Cunle Guo, Xi Dong, Yuanyuan Li, Sheng Wei, Qingyan Jiao, Yonghao Yu, Yonghao Yu, Hui Shen, Hui Shen   +13 more
doaj   +1 more source

Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aβ oligomerization. [PDF]

PLoS ONE, 2011
Accumulation and deposition of β-amyloid protein (Aβ) are the hallmark features of Alzheimer's disease. The inhalation anesthetic isoflurane has been shown to induce caspase activation and increase Aβ accumulation.
Yiying Zhang, Yu Zhen, Yuanlin Dong, Zhipeng Xu, Yun Yue, Todd E Golde, Rudolph E Tanzi, Robert D Moir, Zhongcong Xie   +8 more
doaj   +1 more source

Isoflurane anesthesia initiated at the onset of reperfusion attenuates oxidative and hypoxic-ischemic brain injury.

PLoS ONE, 2015
This study demonstrates that in mice subjected to hypoxia-ischemia (HI) brain injury isoflurane anesthesia initiated upon reperfusion limits a release of mitochondrial oxidative radicals by inhibiting a recovery of complex-I dependent mitochondrial ...
Sergey A Sosunov, Xavier Ameer, Zoya V Niatsetskaya, Irina Utkina-Sosunova, Veniamin I Ratner, Vadim S Ten   +5 more
doaj   +1 more source

Volatile anesthetics, not intravenous anesthetic propofol bind to and attenuate the activation of platelet receptor integrin αIIbβ3. [PDF]

PLoS ONE, 2013
In clinical reports, the usage of isoflurane and sevoflurane was associated with more surgical field bleeding in endoscopic sinus surgeries as compared to propofol.
Koichi Yuki, Weiming Bu, Motomu Shimaoka, Roderic Eckenhoff   +3 more
doaj   +1 more source

Activation of D1 Dopamine Receptors Induces Emergence from Isoflurane General Anesthesia [PDF]

, 2012
Background: A recent study showed that methylphenidate induces emergence from isoflurane anesthesia. Methylphenidate inhibits dopamine and norepinephrine reuptake transporters.
Brown, Emery N., Chemali, Jessica J., Solt, Ken, Taylor, Norman E.   +3 more
core   +1 more source

Isoflurane Conditioning Provides Protection against Subarachnoid Hemorrhage Induced Delayed Cerebral Ischemia through NF-kB Inhibition

Biomedicines, 2023
Delayed cerebral ischemia (DCI) is the largest treatable cause of poor outcome after aneurysmal subarachnoid hemorrhage (SAH). Nuclear Factor Kappa-light-chain-enhancer of Activated B cells (NF-kB), a transcription factor known to function as a pivotal ...
Meizi Liu, Keshav Jayaraman, Jogender Mehla, Deepti Diwan, James W. Nelson, Ahmed E. Hussein, Ananth K. Vellimana, Yousef Abu-Amer, Gregory J. Zipfel, Umeshkumar Athiraman   +9 more
doaj   +1 more source

The role of Volatile Anesthetics in Cardioprotection: a systematic review. [PDF]

, 2012
This review evaluates the mechanism of volatile anesthetics as cardioprotective agents in both clinical and laboratory research and furthermore assesses possible cardiac side effects upon usage.
Applegate, Richard L, Krafft, Paul R, Leitzke, Arthur S, Tang, Jiping, Van Allen, Nicole R, Zhang, John H   +5 more
core   +1 more source