Euthanasia of laboratory mice: Are isoflurane and sevoflurane real alternatives to carbon dioxide?
PLoS ONE, 2018 In the European Union (EU) millions of laboratory mice are used and killed for experimental and other scientific purposes each year. Although controversially discussed, the use of carbon dioxide (CO2) is still permitted for killing rodents according to ...
N. Marquardt +6 more
semanticscholar +1 more source
Isoflurane anesthesia promotes cognitive impairment by inducing expression of β-amyloid protein-related factors in the hippocampus of aged rats. [PDF]
PLoS ONE, 2017 Isoflurane anesthesia has been shown to be responsible for cognitive impairment in Alzheimer's disease (AD) and development of AD in the older age groups.
Shuai Zhang +6 more
doaj +1 more source
Comparison of the effects of two anesthetics, isoflurane and urethane, on bladder function in rats
Journal of Pharmacological Sciences, 2023 We compared the effects of two anesthetics, isoflurane and urethane on bladder function in rats. Arterial pressure, cystometry (CMG), and rhythmic bladder contractions (RBCs) under isovolumetric conditions, mechanosensitive single-unit afferent ...
Naoki Aizawa, Tomoe Fujita
doaj +1 more source
Activation of D1 Dopamine Receptors Induces Emergence from Isoflurane General Anesthesia [PDF]
, 2012 Background: A recent study showed that methylphenidate induces emergence from isoflurane anesthesia. Methylphenidate inhibits dopamine and norepinephrine reuptake transporters.
Brown, Emery N. +3 more
core +1 more source
Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aβ oligomerization. [PDF]
PLoS ONE, 2011 Accumulation and deposition of β-amyloid protein (Aβ) are the hallmark features of Alzheimer's disease. The inhalation anesthetic isoflurane has been shown to induce caspase activation and increase Aβ accumulation.
Yiying Zhang +8 more
doaj +1 more source
Interpreting Neuroendocrine Hormones, Corticosterone, and Blood Glucose to Assess the Wellbeing of Anesthetized Rats during Euthanasia [PDF]
, 2018 Current recommendations for assessing animal wellbeing during euthanasia suggest that measuring neuroendocrine hormones-such as ACTH, noradrenaline, and adrenaline-is preferable to measuring corticosterone and blood glucose because of the sensitivity of ...
Hickman, Debra L.
core +1 more source
Journal of Neurophysiology, 2018 General anesthesia is ubiquitous in research and medicine, yet although the molecular mechanisms of anesthetics are well characterized, their ultimate influence on cortical electrophysiology remains unclear.
Nicholas J. Michelson, T. Kozai
semanticscholar +1 more source
Anesthetic isoflurane increases phosphorylated tau levels mediated by caspase activation and Aβ generation. [PDF]
PLoS ONE, 2012 Anesthetic isoflurane has been shown to promote Alzheimer's disease (AD) neuropathogenesis by inducing caspase activation and accumulation of β-amyloid (Aβ). Phosphorylation of tau protein is another important feature of AD neuropathogenesis.
Yuanlin Dong +4 more
doaj +1 more source
BJA Open, 2022 Background: Emerging data suggest that volatile anaesthetic agents may be protective during critical illness. Methods: Three-month-old Sprague Dawley rats were randomly allocated to one of four groups: isoflurane during surgery followed by 3 days of ...
Keita Ikeda +2 more
doaj +1 more source
USE OF INHALANT ANESTHETICS IN THREE SNAKE SPECIES [PDF]
, 2000 Different snake species respond differently to various anesthetic agents. Hence, an anesthetic procedure developed for one species cannot necessarily be safely transferred to another species.
Blouin-Demers, Gabriel +4 more
core +2 more sources