Results 51 to 60 of about 301,160 (383)

Repeated isoflurane in adult male mice leads to acute and persistent motor decrements with long‐term modifications in corpus callosum microstructural integrity

Journal of Neuroscience Research, 2018
Isoflurane is a commonly used inhalational anesthetic, clinically and in animal experimental studies. Although it has been reported as safe, recent findings suggest that despite widespread use, isoflurane‐induced inhalational anesthesia can lead to ...
Nikita M. Bajwa, Jeong Bin Lee, Shina Halavi, R. Hartman, A. Obenaus   +4 more
semanticscholar   +1 more source

ANGPTL2 Deletion Attenuates Neuroinflammation and Cognitive Dysfunction Induced by Isoflurane in Aged Mice through Modulating MAPK Pathway

Mediators of Inflammation, 2023
Postoperative cognitive dysfunction (POCD) is a well-known complication after surgery with cognitive impairments. Angiopoietin-like protein 2 (ANGPTL2) has been found to be associated with inflammation.
Xiaoyan Huang, Zegeng Su, Shuncai Zhang, Xiaoling Xu, Bo Yang, Xiang Xu   +5 more
doaj   +1 more source

Janus Kinase Mediates Faster Recovery From Sevoflurane Anesthesia Than Isoflurane Anesthesia in the Migratory Locusts

Frontiers in Physiology, 2022
Inhalation anesthetics isoflurane and sevoflurane have been widely used in clinical practice for anesthesia. However, the molecular mechanisms underlying the faster recovery from sevoflurane anesthesia than isoflurane anesthesia remain largely ...
Zongyuan Ma, Jialin C. Zheng, Tianzuo Li, Zhongcong Xie, Le Kang   +4 more
doaj   +1 more source

HIF-1α mediates isoflurane-induced vascular protection in subarachnoid hemorrhage [PDF]

, 2015
OBJECTIVE: Outcome after aneurysmal subarachnoid hemorrhage (SAH) depends critically on delayed cerebral ischemia (DCI) – a process driven primarily by vascular events including cerebral vasospasm, microvessel thrombosis, and microvascular dysfunction ...
Gidday, Jeffrey M, Han, Byung Hee, Harries, Michael D, Johnson, Andrew W, Milner, Eric, Nelson, James W, Zipfel, Gregory J   +6 more
core   +3 more sources

Isoflurane produces antidepressant effects and induces TrkB signaling in rodents

Scientific Reports, 2016
A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset of patients, but the neurobiological basis of these observations remains obscure.
H. Antila, M. Ryazantseva, D. Popova, P. Sipilä, R. Guirado, S. Kohtala, I. Yalcin, J. Lindholm, L. Vesa, V. Sato, J. Cordeira, Henri Autio, Mikhail Kislin, M. Rios, S. Joca, P. Casarotto, L. Khiroug, S. Lauri, T. Taira, E. Castrén, T. Rantamäki   +20 more
semanticscholar   +1 more source

Early postnatal exposure to isoflurane causes cognitive deficits and disrupts development of newborn hippocampal neurons via activation of the mTOR pathway

PLoS Biology, 2017
Clinical and preclinical studies indicate that early postnatal exposure to anesthetics can lead to lasting deficits in learning and other cognitive processes.
Eunchai Kang, Danye Jiang, Y. Ryu, Sanghee Lim, Minhye Kwak, Christy D. Gray, Michael Xu, J. Choi, Sue Junn, Jieun Kim, Jing Xu, M. Schaefer, R. Johns, Hongjun Song, G. Ming, C. Mintz   +15 more
semanticscholar   +1 more source

Isoflurane Preconditioning Promotes the Survival and Migration of Bone Marrow Stromal Cells

Cellular Physiology and Biochemistry, 2015
Background: Preconditioning with the volatile anesthetic isoflurane exerts protective effects in animal models of ischemia. The cytoprotective effects of isoflurane are dependent on the expression of hypoxia inducible factor-1 (HIF-1), a dimeric ...
Yu Sun, Qi-fang Li, Jia Yan, Rong Hu, Hong Jiang   +4 more
doaj   +1 more source

Upregulation of Cdh1 Attenuates Isoflurane-Induced Neuronal Apoptosis and Long-Term Cognitive Impairments in Developing Rats

Frontiers in Cellular Neuroscience, 2017
Neonatal exposure to isoflurane can result in neuroapoptosis and persistent cognitive impairments. However, the underlying mechanisms remain elusive. Anaphase-promoting complex/cyclosome (APC/C) and its co-activator Cdh1 are E3 ubiquitin ligases that ...
Xuan Li, Kai Wei, Rong Hu, Bo Zhang, Li Li, Li Wan, Chuanhan Zhang, Wenlong Yao   +7 more
doaj   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Enhanced charge-independent Mitochondrial Free Ca\u3csup\u3e2+\u3c/sup\u3e and Attenuated ADP-induced NADH Oxidation by Isoflurane: Implications for Cardioprotection [PDF]

, 2012
Modulation of mitochondrial free Ca2 + ([Ca2 +]m) is implicated as one of the possible upstream factors that initiates anesthetic-mediated cardioprotection against ischemia–reperfusion (IR) injury.
Agarwal, Bhawana, Bosnjak, Zeljko J., Camara, Amadou K.S., Dash, Ranjan K., Stowe, David F.   +4 more
core   +1 more source