Results 51 to 60 of about 312,228 (350)

Isoflurane anesthesia initiated at the onset of reperfusion attenuates oxidative and hypoxic-ischemic brain injury.

PLoS ONE, 2015
This study demonstrates that in mice subjected to hypoxia-ischemia (HI) brain injury isoflurane anesthesia initiated upon reperfusion limits a release of mitochondrial oxidative radicals by inhibiting a recovery of complex-I dependent mitochondrial ...
Sergey A Sosunov, Xavier Ameer, Zoya V Niatsetskaya, Irina Utkina-Sosunova, Veniamin I Ratner, Vadim S Ten   +5 more
doaj   +1 more source

Sleep Deprivation Aggravates Cognitive Impairment by the Alteration of Hippocampal Neuronal Activity and the Density of Dendritic Spine in Isoflurane-Exposed Mice

Frontiers in Behavioral Neuroscience, 2020
Isoflurane contributes to cognitive deficits when used as a general anesthetic, and so does sleep deprivation (SD). Patients usually suffer from insomnia before an operation due to anxiety, fear, and other factors. It remains unclear whether preoperative
Kai Zhang, Kai Zhang, Naqi Lian, Naqi Lian, Ran Ding, Cunle Guo, Xi Dong, Yuanyuan Li, Sheng Wei, Qingyan Jiao, Yonghao Yu, Yonghao Yu, Hui Shen, Hui Shen   +13 more
doaj   +1 more source

Janus Kinase Mediates Faster Recovery From Sevoflurane Anesthesia Than Isoflurane Anesthesia in the Migratory Locusts

Frontiers in Physiology, 2022
Inhalation anesthetics isoflurane and sevoflurane have been widely used in clinical practice for anesthesia. However, the molecular mechanisms underlying the faster recovery from sevoflurane anesthesia than isoflurane anesthesia remain largely ...
Zongyuan Ma, Jialin C. Zheng, Tianzuo Li, Zhongcong Xie, Le Kang   +4 more
doaj   +1 more source

Volatile anesthetics, not intravenous anesthetic propofol bind to and attenuate the activation of platelet receptor integrin αIIbβ3. [PDF]

PLoS ONE, 2013
In clinical reports, the usage of isoflurane and sevoflurane was associated with more surgical field bleeding in endoscopic sinus surgeries as compared to propofol.
Koichi Yuki, Weiming Bu, Motomu Shimaoka, Roderic Eckenhoff   +3 more
doaj   +1 more source

USE OF INHALANT ANESTHETICS IN THREE SNAKE SPECIES [PDF]

, 2000
Different snake species respond differently to various anesthetic agents. Hence, an anesthetic procedure developed for one species cannot necessarily be safely transferred to another species.
Blouin-Demers, Gabriel, Brown, Gregory P., Parent, Christopher E., Shilton, Catherine M., Weatherhead, Patrick J.   +4 more
core   +2 more sources

Isoflurane-induced postoperative cognitive dysfunction is mediated by hypoxia-inducible factor-1α-dependent neuroinflammation in aged rats

Molecular Medicine Reports, 2018
Elderly patients are at high risk of developing postoperative cognitive dysfunction (POCD) after prolonged exposure to inhaled anesthetics. However, the pathogenesis of POCD remains unknown.
Yiyun Cao, Zhengqian Li, Lijun Ma, C. Ni, Lunxu Li, N. Yang, C. Shi, Xiangyang Guo   +7 more
semanticscholar   +1 more source

Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aβ oligomerization. [PDF]

PLoS ONE, 2011
Accumulation and deposition of β-amyloid protein (Aβ) are the hallmark features of Alzheimer's disease. The inhalation anesthetic isoflurane has been shown to induce caspase activation and increase Aβ accumulation.
Yiying Zhang, Yu Zhen, Yuanlin Dong, Zhipeng Xu, Yun Yue, Todd E Golde, Rudolph E Tanzi, Robert D Moir, Zhongcong Xie   +8 more
doaj   +1 more source

General anesthesia does not have persistent effects on attention in rodents [PDF]

, 2019
Background: Studies in animals have shown that general anesthesia can cause persistent spatial memory impairment, but the influence of anesthetics on other cognitive functions is unclear.
Amanda G. Nelson, George A. Mashour, George A. Mashour, Katherine A. LaTendresse, Margaret Phyle, Michael S. Avidan, Romi E. Ajluni, Viviane S. Hambrecht-Wiedbusch, Viviane S. Hambrecht-Wiedbusch   +8 more
core   +2 more sources

Awake chronic mouse model of targeted pial vessel occlusion via photothrombosis [PDF]

, 2020
Animal models of stroke are used extensively to study the mechanisms involved in the acute and chronic phases of recovery following stroke. A translatable animal model that closely mimics the mechanisms of a human stroke is essential in understanding ...
Boas, David A., Chen, Ichun Anderson, Cheng, Xiaojun, Erdener, Sefik Evren, Kılıç, Kıvılcım, Kura, Sreekanth, Lee, Blaire Ss, Postnov, Dmitry, Sunil, Smrithi, Tang, Jianbo   +9 more
core   +1 more source

Repeated isoflurane in adult male mice leads to acute and persistent motor decrements with long‐term modifications in corpus callosum microstructural integrity

Journal of Neuroscience Research, 2018
Isoflurane is a commonly used inhalational anesthetic, clinically and in animal experimental studies. Although it has been reported as safe, recent findings suggest that despite widespread use, isoflurane‐induced inhalational anesthesia can lead to ...
Nikita M. Bajwa, Jeong Bin Lee, Shina Halavi, R. Hartman, A. Obenaus   +4 more
semanticscholar   +1 more source