Results 71 to 80 of about 12,749 (205)

Analgesic effect in humans of subanaesthetic isoflurane concentrations evaluated by evoked potentials [PDF]

, 1995
The aim of this study was to see if an analgesic effect of subanaesthetic concentrations of isoflurane could be detected with evoked potentials elicited by nociceptive stimuli.
Fischer, M., Arendt-Nielsen, Lars, Bak, Peter, Bjerring, Peter, Bak, P., Arendt-Nielsen, L., Zbinden, A. M., Roth, D., Petersen-Felix, S., Bjerring, P., Petersen-Felix, Steen   +10 more
core   +3 more sources

Computed Tomography‐ and Photoacoustic Imaging‐Active Bioresorbable Electrospun Bismuth Nanoparticle‐Infused Small‐Diameter Vascular Grafts

Advanced Healthcare Materials, EarlyView.
A polymeric graft loaded with radiopaque bismuth nanoparticles is expected to undergo gradual polymer resorption and nanoparticle release. This design enables noninvasive, multimodal monitoring of device integrity, patency, and degradation using computed tomography alongside ultrasound and photoacoustic imaging over 12 weeks.
Allan John R. Barcena, Joy Vanessa D. Perez, Marvin R. Bernardino, Dominic Karl M. Bolinas, Kitz Paul D. Marco, Kim Claudette J. Fernandez, Archana Mishra, Erin Marie D. San Valentin, Jossana A. Damasco, Gino Martin Canlas, Natalie Fowlkes, Richard R. Bouchard, Steven Y. Huang, Marites P. Melancon   +13 more
wiley   +1 more source

Azi-isoflurane, a Photolabel Analog of the Commonly Used Inhaled General Anesthetic Isoflurane. [PDF]

, 2010
Volatility and low-affinity hamper an ability to define molecular targets of the inhaled anesthetics. Photolabels have proven to be a useful approach in this regard, although none have closely mimicked contemporary drugs. We report here the synthesis and
Bhattacharji, Aditya, Dailey, William P, Xi, Jin, Eckenhoff, Roderic G, Shimaoka, Motomu, Covarrubias, Manuel   +5 more
core   +1 more source

In Vivo Monitoring of Thrombo‐Inflammatory Biomarkers via Molecularly Imprinted Polymer‐Integrated Hydrogel Microneedles

Advanced Materials, EarlyView.
A wearable electrochemical microneedle patch integrates Prussian Blue redox transduction with molecularly imprinted polymer recognition for reagent‐free sampling and detection of thrombo‐inflammatory biomarkers in dermal interstitial fluid. The platform tracks thrombin and inflammatory cytokines with sensitive in vitro, ex vivo, and in vivo performance,
Mahmoud Ayman Saleh, Peyman GhavamiNejad, Arash Khorrami Jahromi, Sanjana Srikant, Sripadh Guptha Yedire, Fatemeh Keyvani, Roozbeh Siavash Moakhar, Sajad Shiekh, Mackenzie Graham, Joe Quadrilatero, Mahla Poudineh, Sara Mahshid   +11 more
wiley   +1 more source

A Geometrically Transient Platform for Bioelectronic Implants

Advanced Materials, EarlyView.
Minimally invasive bioelectronic implants often compromise performance for smaller sizes. To resolve this optimization dilemma, a wireless bioelectronic implant with a transient geometry is introduced (MiFi). The origami‐inspired device miniaturizes up to sixfold for syringe insertion and autonomously unfolds post‐implantation.
Selin Olenik, John D. Goodwin, Atharv Naik, Philip Coatsworth, Ioi Chit Cheung, Farbod Amirghasemi, Anies Sohi, Ehsan Abedi, Tayeb Tadlaoui, Maral P. S. Mousavi, Andriy S. Kozlov, Victoria Salem, Andrew S. Cowburn, Firat Guder   +13 more
wiley   +1 more source

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

Effects of clonidine, isoflurane, and the clonidine+isoflurane association in isolated hearts.

, 2023
Background: Isoflurane has been consecrated as an anesthetic drug of choise in heart surgeries, as it presents characteristics that ensure the preservation of cardiac indexes and myocardial stability. Recently, alpha-adrenergic agents, mainly Clonidine,
Alberti, Luiz Ronaldo, Zocratto, Orlando Barreto, Dupin, João Bosco   +2 more
core   +1 more source

Esterified Cholesterol Conjugates Enable LNP‐Mediated mRNA Delivery to the Blood–Brain Barrier Following Intravenous Administration

Advanced Materials, EarlyView.
A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian, Xu Wang, Alexis Pacheco Benitez, Erick Guerrero, Yaou Duan, Jingwen Wei, Lukas Farbiak, Daniel J. Siegwart   +7 more
wiley   +1 more source

Self‐Assembling Copolymers Encapsulating Single Endothelial Cells Induce Endogenous ECM Deposition and Vascular Regeneration

Advanced Materials, EarlyView.
This study presents the first demonstration of stable sub‐50‐micron single‐cell GPM vesicles fabricated through the intrinsic self‐assembly of an amphiphilic copolymer. Hierarchical assembly of cell containing GPM vesicles into microspheres enable tunable, sustained cell delivery with immune protection.
Viola B. Morris, Sangho Lee, Kalp Soni, Simon He, Matthew Huang, Dandan Chen, Dae Hoon Lee, Kyung Hee Kim, Seonggeon Cho, Laura Pencea, Divit Jain, Young‐Sup Yoon   +11 more
wiley   +1 more source

A pilot study on midazolam sedation for murine echocardiography: A potential alternative to isoflurane anesthesia and awake imaging

Physiological Reports
Isoflurane anesthesia is often used to facilitate murine echocardiography, but can suppress cardiac function. Awake imaging avoids pharmacological interference, but can induce sympathetic activation. In this Midazolam sedation.
Bart Jacobs, Sarah Derde, Lies Langouche, Jan D'hooge, Nadia Salerno, Sandro Queirós, Greet Van den Berghe, Annette Caenen, Jan Gunst   +8 more
doaj   +1 more source