A Versatile, Portable Intravital Microscopy Platform for Studying Beta-cell Biology In Vivo [PDF]
, 2019 The pancreatic islet is a complex micro-organ containing numerous cell types, including endocrine, immune, and endothelial cells. The communication of these systems is lost upon isolation of the islets, and therefore the pathogenesis of diabetes can only
Conteh, Abass M. +11 more
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Blood/gas partition coefficients of halothane, isoflurane and sevoflurane in horse blood [PDF]
, 2017 Background. Blood/gas partition coefficients (λb/g) for volatile agents in horse blood are reported for halothane but not for isoflurane and sevoflurane. We measured the λb/g of halothane, isoflurane and sevoflurane in the blood of fasted horses.
Bergadano, A. +4 more
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Propofol inhibits prokaryotic voltage-gated Na+ channels by promoting activation-coupled inactivation [PDF]
, 2018 Propofol is widely used in the clinic for the induction and maintenance of general anesthesia. As with most general anesthetics, however, our understanding of its mechanism of action remains incomplete.
Carnevale, Vincenzo +4 more
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Calibrated forceps model of spinal cord compression injury. [PDF]
, 2015 Compression injuries of the murine spinal cord are valuable animal models for the study of spinal cord injury (SCI) and spinal regenerative therapy.
Ariza, Jeanelle +3 more
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Neuroprotective Properties of Xenon. [PDF]
, 2020 Xenon is a rare noble gas that was introduced into clinical practice more than 70 years ago. Xenon's clinical properties are predicated by its ability to fit into preformed cavities of macromolecules thereby altering their biological functions.
Laitio, Timo, Maze, Mervyn
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Accurate molecular imaging of small animals taking into account animal models, handling, anaesthesia, quality control and imaging system performance [PDF]
, 2015 Small-animal imaging has become an important technique for the development of new radiotracers, drugs and therapies. Many laboratories have now a combination of different small-animal imaging systems, which are being used by biologists, pharmacists ...
Bankstahl, Jens +5 more
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Frontiers in Veterinary Science, 2019 Introduction: Tafonius is an anesthesia machine with computer-controlled monitor and ventilator. We compared the isoflurane fluctuations in the circuit with manual (MF) or computer-driven (CF) flowmeters, investigated the origin of the differences and ...
Mathieu Raillard +3 more
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Isoflurane depresses hippocampal CA1 glutamate nerve terminals without inhibiting fiber volleys
BMC Neuroscience, 2006 Background Anesthetic-induced CNS depression is thought to involve reduction of glutamate release from nerve terminals. Recent studies suggest that isoflurane reduces glutamate release by block of Na channels.
MacIver M Bruce, Winegar Bruce D
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Continuous volumetric imaging via an optical phase-locked ultrasound lens
, 2016 In vivo imaging at high spatiotemporal resolution is key to the understanding of complex biological systems. We integrated an optical phase-locked ultrasound lens into a two-photon fluorescence microscope and achieved microsecond-scale axial scanning ...
Cui, M. +7 more
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Physostigmine and Methylphenidate Induce Distinct Arousal States During Isoflurane General Anesthesia in Rats [PDF]
, 2016 BACKGROUND: Although emergence from general anesthesia is clinically treated as a passive process driven by the pharmacokinetics of drug clearance, agents that hasten recovery from general anesthesia may be useful for treating delayed emergence ...
Ba, Demba E +8 more
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