Results 91 to 100 of about 12,749 (205)
Ferroptosis Contributes to Isoflurane Neurotoxicity [PDF]
, 2019 The underlying mechanisms of isoflurane neurotoxicity in the developing brain remain unclear. Ferroptosis is a recently characterized form of programmed cell death distinct from apoptosis or autophagy, characterized by iron-dependent reactive oxygen ...
Yan Luo +3 more
core +1 more source
Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency
Advanced Materials, EarlyView.As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang +12 more
wiley +1 more source
Cell proliferation under isoflurane.
, 2019 RCC4-EV and RCC4-VHL cells were grown for 48 h with or without exposure to 2% isoflurane for 2 h (A and C). RCC4-EV were grown for 24 h with or without exposure to 100 μM YC-1 or 2% isoflurane (B and C). (A and B) Cell growth at indicated time points, as
Hidemasa Bono (3011) +7 more
core +1 more source
3D Printed Photon Shield Assembly for Low‐Noise Visual Stimulation During Two‐Photon Imaging in Mice
Advanced Materials Technologies, EarlyView.We present the Photon Shield, an open‐hardware system for low‐noise two‐photon calcium imaging during visual stimulation in mice. Combining a 3D‐printed headplate and rail‐mounted shield substantially reduces stray‐light contamination, as quantitatively verified. Functional validation confirms reliable cortical responses. Open design files enable broad
Gergely Katona +6 more
wiley +1 more source
Cell migration under isoflurane.
, 2019 RCC4-EV and RCC4-VHL cells were allowed to migrate for 0–12 h after exposure 0% or 2% with or without 2% isoflurane treatment for 2 h. Migration rate was assessed as described in Materials and Methods. (A) Cell migration at 0 h and 12 h.
Hidemasa Bono (3011) +7 more
core +1 more source
Tumbling Magnetic Microrobots for Targeted In Vivo Drug Delivery in the GI Tract
Advanced Robotics Research, EarlyView.We introduce a microrobot design and integrated system for on‐demand targeted drug release in the gastrointestinal tract. The microrobot has an embedded magnet for actuation with external magnetic fields and is visualized in real time using ultrasound. It has two drug release ports sealed with a thermally sensitive wax. Local heating of the wax using a
Aaron C. Davis +7 more
wiley +1 more source
Isoflurane's Effect on Protein Conformation as a Proposed Mechanism for Preconditioning
Biochemistry Research International, 2011 Persistent alteration of protein conformation due to interaction with isoflurane may be a novel molecular aspect of preconditioning. We preincubated human serum albumin with isoflurane, dialyzed to release agent, and assessed protein conformation ...
Michelle R. Baker +5 more
doaj +1 more source
Neural Regeneration Research, 2016 Isoflurane is a widely used inhaled anesthetic in the clinical setting. However, the mechanism underlying its effect on consciousness is under discussion.
Yi-qing Yin +5 more
doaj +1 more source
Advanced Science, EarlyView.This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan +17 more
wiley +1 more source
Isoflurane depresses hippocampal CA1 glutamate nerve terminals without inhibiting fiber volleys
BMC Neuroscience, 2006 Background Anesthetic-induced CNS depression is thought to involve reduction of glutamate release from nerve terminals. Recent studies suggest that isoflurane reduces glutamate release by block of Na channels.
MacIver M Bruce, Winegar Bruce D
doaj +1 more source