Results 111 to 120 of about 21,511 (293)

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Expression of HIFs under isoflurane.

, 2019
(A) HIF expression after 8 h at 20% and 1% O2, (B) after 8 h at 20% O2 with or without 2% isoflurane, (C) and after 8 h at 1% O2 with or without 2% isoflurane. Cells were harvested, and 35 μg whole-cell lysates were immunoblotted using primary antibodies
Hidemasa Bono (3011), Teppei Iwai (6589319), Takeo Uba (4856998), Kiichi Hirota (47433), Munenori Kusunoki (3521690), Tomohiro Shoji (4856995), Yoshiyuki Matsuo (3521696), Chisato Sumi (3521705)   +7 more
core   +1 more source

Phenylephrine Increases Regional Cerebral Blood Flow Following Hemorrhage during Isoflurane–Oxygen Anesthesia [PDF]

, 1989
W. Alan C. Mutch, Louise A. Mato, K. R. A. Ringaert   +2 more
openalex   +1 more source

In Vivo Microplastic Detection With Photoacoustic Imaging

Advanced Science, EarlyView.
ABSTRACT Microplastics are posing an escalating threat to both ecological systems and human health. Yet, current methods for investigating their bioaccumulation are highly invasive, requiring destructive analysis of ex vivo tissues via mass spectrometry, dye labelling, or Raman microspectroscopy.
Joseph C. Bear, Olumide Ogunlade, Jayvian Mavi, Emily J. Deniszczyc, Daolong Chen, Heeva Javaheri, Paul Beard, Mark F. Lythgoe, Daniel J. Stuckey, P. Stephen Patrick   +9 more
wiley   +1 more source

Evaluation of the isoflurane-sparing effects of lidocaine infusion during umbilical surgery in calves

, 2011
OBJECTIVE: To evaluate the isoflurane-sparing effects of lidocaine administered by constant rate infusion (CRI) during umbilical surgery in calves. STUDY DESIGN: Randomized 'blinded' prospective clinical study. ANIMALS: Thirty calves (mean 4.7 +/- SD 2.5
Spadavecchia, Claudia, Levionnois, Olivier, Steiner, Adrian, Nasser Vesal, Claudia Spadavecchia, Kirscher, Franziska, Franziska Kirscher, Adrian Steiner, Olivier L Levionnois, Vesal, N.   +9 more
core   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Physiological parameters during isoflurane exposure.

, 2013
Isoflurane exposure did not affect arterial blood gas values and blood glucose levels significantly. Values are mean ± S.E.M. n = 5 for each group.Con = control; Mino = minocycline; Iso = isoflurane; PaCO2 = arterial carbon dioxide tension; PaO2 ...
Feijuan Kong (403531), Huishun Lu (403534), Yuan Cheng (72244), Leilei Ma (403533), Wenwen Hu (403536), Shuping Chen (403532), Honghai Zhang (403535)   +6 more
core   +1 more source

Electroacupuncture Improves the Learning and Memory by Modulating Hippocampal Glucose Metabolism through IGF1/IGF1R Signaling in Alzheimer's Disease

Advanced Science, EarlyView.
Electroacupuncture (EA) ameliorates learning and memory function in 5×FAD mice by regulating the brain glucose metabolic network. This neuroprotective effect is closely related to enhancing neuronal energy utilization via the IGF1/IGF1R signaling pathway.
Shengxiang Liang, Qingqing Zhang, Xiuxiu Wang, Lixin Peng, Xinru Ji, Jiawei Wang, Yusi Zhang, Jiayang Huang, Junchao Yang, Shiqi Zhan, Yiping Xiao, Weilin Liu, Lidian Chen   +12 more
wiley   +1 more source

Isoflurane preconditioning induced genomic changes in mouse cortex

BJA Open
Background: Altered patterns of genetic expression induced by isoflurane preconditioning in mouse brain have not yet been investigated. The aim of our pilot study is to examine the temporal sequence of changes in the transcriptome of mouse brain cortex ...
Umeshkumar Athiraman, Tusar Giri
doaj   +1 more source

Isoflurane's Effect on Protein Conformation as a Proposed Mechanism for Preconditioning

Biochemistry Research International, 2011
Persistent alteration of protein conformation due to interaction with isoflurane may be a novel molecular aspect of preconditioning. We preincubated human serum albumin with isoflurane, dialyzed to release agent, and assessed protein conformation ...
Michelle R. Baker, Sean K. Benton, Christopher S. Theisen, Chad A. McClintick, Eugene E. Fibuch, Norbert W. Seidler   +5 more
doaj   +1 more source