Results 61 to 70 of about 307,909 (397)

Inhibiting the NLRP3 Inflammasome With MCC950 Ameliorates Isoflurane-Induced Pyroptosis and Cognitive Impairment in Aged Mice

Frontiers in Cellular Neuroscience, 2018
Nod-like receptor protein 3 (NLRP3) inflammasome activation has been implicated in the pathogenesis of general anesthesia (GA)-induced neuroinflammation and cognitive impairment in aged rodents.
Yunxia Fan, Liwu Du, Qun Fu, Zhi-qiang Zhou, Jingyu Zhang, Guo-min Li, Jing Wu   +6 more
semanticscholar   +1 more source

Isoflurane anesthesia initiated at the onset of reperfusion attenuates oxidative and hypoxic-ischemic brain injury.

PLoS ONE, 2015
This study demonstrates that in mice subjected to hypoxia-ischemia (HI) brain injury isoflurane anesthesia initiated upon reperfusion limits a release of mitochondrial oxidative radicals by inhibiting a recovery of complex-I dependent mitochondrial ...
Sergey A Sosunov, Xavier Ameer, Zoya V Niatsetskaya, Irina Utkina-Sosunova, Veniamin I Ratner, Vadim S Ten   +5 more
doaj   +1 more source

Isoflurane impairs oogenesis through germ cell apoptosis in C. elegans

Scientific Reports, 2021
Anesthetic isoflurane has been reported to induce toxicity. However, the effects of isoflurane on fecundity remain largely unknown. We established a system in C. elegans to investigate the effects of isoflurane on oogenesis.
Tao Zhang, Cheng Ni, Cheng Li, Pan Lu, Dan Chen, Yuanlin Dong, Johnathan R. Whetstine, Yiying Zhang, Zhongcong Xie   +8 more
doaj   +1 more source

Janus Kinase Mediates Faster Recovery From Sevoflurane Anesthesia Than Isoflurane Anesthesia in the Migratory Locusts

Frontiers in Physiology, 2022
Inhalation anesthetics isoflurane and sevoflurane have been widely used in clinical practice for anesthesia. However, the molecular mechanisms underlying the faster recovery from sevoflurane anesthesia than isoflurane anesthesia remain largely ...
Zongyuan Ma, Jialin C. Zheng, Tianzuo Li, Zhongcong Xie, Le Kang   +4 more
doaj   +1 more source

General anesthesia does not have persistent effects on attention in rodents [PDF]

, 2019
Background: Studies in animals have shown that general anesthesia can cause persistent spatial memory impairment, but the influence of anesthetics on other cognitive functions is unclear.
Amanda G. Nelson, George A. Mashour, George A. Mashour, Katherine A. LaTendresse, Margaret Phyle, Michael S. Avidan, Romi E. Ajluni, Viviane S. Hambrecht-Wiedbusch, Viviane S. Hambrecht-Wiedbusch   +8 more
core   +2 more sources

Sleep Deprivation Aggravates Cognitive Impairment by the Alteration of Hippocampal Neuronal Activity and the Density of Dendritic Spine in Isoflurane-Exposed Mice

Frontiers in Behavioral Neuroscience, 2020
Isoflurane contributes to cognitive deficits when used as a general anesthetic, and so does sleep deprivation (SD). Patients usually suffer from insomnia before an operation due to anxiety, fear, and other factors. It remains unclear whether preoperative
Kai Zhang, Kai Zhang, Naqi Lian, Naqi Lian, Ran Ding, Cunle Guo, Xi Dong, Yuanyuan Li, Sheng Wei, Qingyan Jiao, Yonghao Yu, Yonghao Yu, Hui Shen, Hui Shen   +13 more
doaj   +1 more source

Minocycline attenuates cognitive impairment induced by isoflurane anesthesia in aged rats. [PDF]

PLoS ONE, 2013
Postoperative cognitive dysfunction (POCD) is a clinical phenomenon characterized by cognitive deficits in patients after anesthesia and surgery, especially in geriatric surgical patients. Although it has been documented that isoflurane exposure impaired
Feijuan Kong, Shuping Chen, Yuan Cheng, Leilei Ma, Huishun Lu, Honghai Zhang, Wenwen Hu   +6 more
doaj   +1 more source

Volatile anesthetics, not intravenous anesthetic propofol bind to and attenuate the activation of platelet receptor integrin αIIbβ3. [PDF]

PLoS ONE, 2013
In clinical reports, the usage of isoflurane and sevoflurane was associated with more surgical field bleeding in endoscopic sinus surgeries as compared to propofol.
Koichi Yuki, Weiming Bu, Motomu Shimaoka, Roderic Eckenhoff   +3 more
doaj   +1 more source

Isoflurane-induced postoperative cognitive dysfunction is mediated by hypoxia-inducible factor-1α-dependent neuroinflammation in aged rats

Molecular Medicine Reports, 2018
Elderly patients are at high risk of developing postoperative cognitive dysfunction (POCD) after prolonged exposure to inhaled anesthetics. However, the pathogenesis of POCD remains unknown.
Yiyun Cao, Zhengqian Li, Lijun Ma, C. Ni, Lunxu Li, N. Yang, C. Shi, Xiangyang Guo   +7 more
semanticscholar   +1 more source

Repeated isoflurane in adult male mice leads to acute and persistent motor decrements with long‐term modifications in corpus callosum microstructural integrity

Journal of Neuroscience Research, 2018
Isoflurane is a commonly used inhalational anesthetic, clinically and in animal experimental studies. Although it has been reported as safe, recent findings suggest that despite widespread use, isoflurane‐induced inhalational anesthesia can lead to ...
Nikita M. Bajwa, Jeong Bin Lee, Shina Halavi, R. Hartman, A. Obenaus   +4 more
semanticscholar   +1 more source