Results 221 to 230 of about 9,712,779 (339)

Chronic myeloid leukemia presenting with isolated central nervous system lymphoid blast crisis: A case report. [PDF]

Rare Tumors
Zarama-Valenzuela Á, Arévalo-Zambrano M, Cadena-Andrade Á, Zárate-Mesa A.   +3 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Study on the mining stress field distribution law beneath isolated coal pillar in close coal seam and reasonable location of the roadway. [PDF]

Sci Rep
Shu S, Wang W, Liu C, Yuan C, Ma Y, Tian X, Du R, Ge S.   +7 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Evaluating the Association Between Core Muscle Injury Symptom Pattern and Concomitant Femoroacetabular Impingement Syndrome. [PDF]

Orthop J Sports Med
Garden AR, Palazzolo Ray AME, Alakhras A, Finerty JT, Darling AJ, Kossoff NR, Romero-Padron MA, Everhart JS.   +7 more
europepmc   +1 more source

Do geographically isolated wetlands influence landscape functions?

Proceedings of the National Academy of Sciences of the United States of America, 2016
M. Cohen, I. Creed, L. Alexander, N. Basu, A. Calhoun, C. Craft, E. D’Amico, E. DeKeyser, L. Fowler, H. Golden, J. Jawitz, Peter I. Kalla, L. Kirkman, C. Lane, M. Lang, S. Leibowitz, David Bruce Lewis, J. Marton, D. McLaughlin, D. Mushet, Hadas Raanan-Kiperwas, M. Rains, Lora M. Smith, Susan C. Walls   +23 more
semanticscholar   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Ischemic cerebellar infarction due to isolated anterior inferior cerebellar artery dissection mimicking peripheral otological symptoms: illustrative case. [PDF]

J Neurosurg Case Lessons
Nemoto S, Takeda R, Jinushi Y, Ogura Y, Nakane M.   +4 more
europepmc   +1 more source

Existential isolation [PDF]

Palliative and Supportive Care, 2017
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source