Results 231 to 240 of about 4,529,061 (305)

Bioactive Compounds from Mangrove-Associated Fungi as Leads Against ESKAPE Pathogens. [PDF]

Life (Basel)
Agrawal S, Dufossé L, Deshmukh SK, Verekar SA.   +3 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Non-specific ECG ST-T abnormalities: cardiac repolarisation memory assessment. [PDF]

Heart
Tereshchenko LG.
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Phytochemical Analysis and Bioevaluation of <i>Echinophora sibthorpiana</i> Guss. (Apiaceae): Antioxidant Capacity, DNA Protection and In Vivo Genotoxic Safety. [PDF]

Antioxidants (Basel)
Gündoğdu S, Erdemli GI, Baran MY, Emecen G, Doğru A, Nemutlu E, Simon A, Kuruüzüm-Uz A.   +7 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

From geographic distance to response delay: Applying a time-based disaster classification in the Philippines. [PDF]

J Clim Chang Health
Sanchez GJ.
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Isolated, reduced diffusing capacity for carbon monoxide in the population - relations to symptoms, smoking and comorbidities. [PDF]

BMC Pulm Med
Hamrefors V, Westerbergh J, Behndig A, Blomberg A, Brandberg J, Carlén A, Egesten A, Ekbom E, Emilsson ÖI, Eriksson MJ, Frølich A, Grote L, Janson C, Karimi R, Moberg A, Persson HL, Pesonen I, Sköld M, Sörensen K, Tanash H, Torén K, Vanfleteren L, Wollmer P, Malinovschi A.   +23 more
europepmc   +1 more source