Results 91 to 100 of about 2,600,660 (302)
Foraminiferal ecology of contemporary isolation basins in Northwest Scotland [PDF]
, 2002 Isolation basins contain high-resolution records of environmental change relating to RSL and climate since the last glacial maximum, and provide valuable data in constraining regional and global ice sheet and earth rheology models.
Laidler, Philip Damien
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Multicenter Assessment of Animal-free Collagenase AF-1 for Human Islet Isolation
Cell Transplantation, 2017 Animal-free (AF) SERVA Collagenase AF-1 and Neutral Protease (NP) AF GMP Grade have recently become available for human islet isolation. This report describes the initial experiences of 3 different islet transplant centers.
Daniel Brandhorst +10 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
3-Difluoromethyl-5-[4-(trifluoromethyl)phenyl]isoxazole
IUCrData, 2018 The title molecule, C11H6F5NO, lies on a mirror plane in the orthorhombic unit cell, with only two F atoms each of the difluoro and trifluoromethyl substituents lying out of the plane.
Hui Zhao
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Macromolecular Materials and EngineeringIsaac Newton once contemplated the fall of an apple, setting in motion a revolution in the understanding of gravity. In a similar spirit of curiosity and inquiry, here a journey is embarked upon to explore the intricate world of viscoelastic damping for ...
Rene Preuer +3 more
doaj +1 more source
, 2018 <p>Work done at Hiroshima University in collaboration with Prof. Toru Nakanishi and Yoshino Hiromi. An implementation of a Zero-Knowledge proof of vertex isolation using accumulators and a few bilinear pairing operations.</p ...
Guru Vamsi Policharla
core +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source