Results 81 to 90 of about 2,600,660 (302)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Identity Reconstruction as a Coping Mechanism in Addiction Recovery: A Pilot Stratified Randomized Controlled Trial of Narrative Therapy Group Intervention

European Journal of Investigation in Health, Psychology and Education
Relapse in substance use disorders remains a persistent clinical challenge. Identity reconstruction, the psychological transition from an internalized “addict” identity to a recovery-oriented self, may be a core coping mechanism for abstinence ...
Peipei Wang, Yanan Li, Xu Cheng, Hong Xie, Huanxian Huang, Jun Yang, Yangwei Chen, Alex Pak Ki Kwok, Jiacheng Chen   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Comparative analysis of C-Reactive protein levels among Non-comorbid, Comorbid, and Multimorbid Hospitalized COVID-19 patients

BMC Infectious Diseases
Background C-reactive protein (CRP) is one of the most commonly monitored inflammatory markers in patients with COVID-19 to gain insight into the inflammation level in the body and to adopt effective disease management and therapeutic strategies.
Maria Shoukat, Haseeb Khan, Moona Nazish, Abdur Rehman, Sheharyar Raashid, Saad Ahmed, Wajid Munir, Abdulwahed Fahad Alrefaei, Massab Umair, Muhammad Osama Bin Abid, Nasim Akhtar, Wajid Zaman, Malik Badshah   +12 more
doaj   +1 more source

Thermal Evolution near Heat-Generating Nuclear Waste Canisters Disposed in Horizontal Drillholes

Energies, 2019
We consider the disposal of spent nuclear fuel and high-level radioactive waste in horizontal holes drilled into deep, low-permeable geologic formations using directional drilling technology.
Stefan Finsterle, Richard A. Muller, Rod Baltzer, Joe Payer, James W. Rector   +4 more
doaj   +1 more source

Stray voltage symptoms common in dairy cattle eliminated by on-farm neutral isolation [PDF]

, 2000
Plan BDairy farmers with stray voltage symptoms in their cattle often spend thousands of dollars to do neutral isolation, which isolates the primary neutral of the electricity provider from the farm neutral to suppress stray voltage from off-farm sources
Nackers, Martin
core  

Base isolation: design and optimization criteria

, 2010
Use of new antiseismic techniques is certainly suitable for buildings of strategic importance and, in general, in the case of very high risk. For ordinary buildings, instead, the cost of base isolation system should be balanced by an equivalent saving in
Clemente P., Giacomo Buffarini, Buffarini G., Paolo Clemente   +3 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Proceedings of the workshop 'Isolation of operators as a consequence of automation'

, 1987
'Isolation' beschreibt den physikalischen, sozialen, psychischen, professionellen und/oder kulturellen Zustand einer Person in ihrer Beziehung zu einem System. Mit dieser Thematik beschaeftigten sich 17 Fachbeitraege auf einer Arbeitstagung.
Deutsche Forschungsanstalt fuer Luft- und Raumfahrt e.V. (DLR), Koeln (Germany). Inst. fuer Flugmedizin, Commission of the European Communities (CEC), Brussels (Belgium), Boehm, H. (ed.)   +2 more
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source